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Acta Oto-Laryngologica Volume 132, 2012 - Issue 4: CORLAS
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ORIGINAL ARTICLE

L-N-Acetylcysteine treatment is associated with improved hearing outcome in sudden idiopathic sensorineural hearing loss

Simon I. AngeliDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence[email protected]
,
Ralph N. Abi-HachemDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
,
Richard J. ViveroDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
,
Fred T. TelischiDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
&
John J. MachadoDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
Pages 369-376 | Received 19 Sep 2011, Accepted 29 Oct 2011, Published online: 21 Jan 2012

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Lennart Weitgasser, Florentina Ferstl, Anna O'Sullivan & Sebastian Rösch. (2023) Autoimmune inner ear disease in a young patient – an unsolvable challenge?. Acta Oto-Laryngologica Case Reports 8:1, pages 29-34.
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Joshua A. Tillinger, Chhavi Gupta, Kadri Ila, Jamal Ahmed, Jeenu Mittal, Thomas R. Van De Water & Adrien A. Eshraghi. (2018) l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro. Acta Oto-Laryngologica 138:8, pages 676-684.
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Chao-Hsien Chen & Yi-Ho Young. (2017) N-acetylcysteine as a single therapy for sudden deafness. Acta Oto-Laryngologica 137:1, pages 58-62.
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Nicole T. Jiam, Philip D. Littlefield & Daniel J. Lee. 2024. Otologic and Lateral Skull Base Trauma. Otologic and Lateral Skull Base Trauma 47 60 .
Mussab Kouka, Nils Bevern, Julia Bitter & Orlando Guntinas-Lichius. (2023) N-Acetylcysteine combined with prednisolone treatment shows better hearing outcome than treatment with prednisolone alone for patients with idiopathic sudden sensorineural hearing loss: a retrospective observational study. European Archives of Oto-Rhino-Laryngology.
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Anna Pisani, Fabiola Paciello, Raffaele Montuoro, Rolando Rolesi, Jacopo Galli & Anna Rita Fetoni. (2023) Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic. Life 13:4, pages 1035.
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Alexander A. Missner, James Dixon Johns, Shoujun Gu & Michael Hoa. (2022) Repurposable Drugs That Interact with Steroid Responsive Gene Targets for Inner Ear Disease. Biomolecules 12:11, pages 1641.
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Margaret T. Dillon, Armine Kocharyan, Ghazal S. Daher, Matthew L. Carlson, William H. Shapiro, Hillary A. Snapp & Jill B. Firszt. (2022) American Cochlear Implant Alliance Task Force Guidelines for Clinical Assessment and Management of Adult Cochlear Implantation for Single-Sided Deafness. Ear & Hearing 43:6, pages 1605-1619.
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Xue Bai, Miao Wang, Xun Niu, Hong Yu, Jian‐Xin Yue & Yu Sun. (2022) Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis. World Journal of Otorhinolaryngology - Head and Neck Surgery 8:3, pages 205-212.
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Shih-Lung Chen, Chih-Yu Hu, Kai-Chieh Chan, Shy-Chyi Chin & Chia-Ying Ho. (2022) Prognostic factors in elderly patients after an intra-tympanic steroid injection for idiopathic sudden sensorineural hearing loss. American Journal of Otolaryngology 43:5, pages 103528.
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Zachary G. Schwam & George B. Wanna. (2022) Update on the Management of Idiopathic Sudden Sensorineural Hearing Loss. Current Otorhinolaryngology Reports 10:3, pages 329-335.
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Lidia Frejo & Jose Antonio Lopez-Escamez. (2022) Cytokines and Inflammation in Meniere Disease. Clinical and Experimental Otorhinolaryngology 15:1, pages 49-59.
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Shih-Lung Chen, Chia-Ying Ho & Shy-Chyi Chin. (2022) Effects of oral N-acetylcysteine combined with oral prednisolone on idiopathic sudden sensorineural hearing loss. Medicine 101:26, pages e29792.
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Andrea Vambutas & Daniella V. Davia. (2021) Biologics for Immune-Mediated Sensorineural Hearing Loss. Otolaryngologic Clinics of North America 54:4, pages 803-813.
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Xue Bai, Sen Chen, Kai Xu, Yuan Jin, Xun Niu, Le Xie, Yue Qiu, Xiao-Zhou Liu & Yu Sun. (2021) N-Acetylcysteine Combined With Dexamethasone Treatment Improves Sudden Sensorineural Hearing Loss and Attenuates Hair Cell Death Caused by ROS Stress. Frontiers in Cell and Developmental Biology 9.
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Wen-Yan Zhu, Xin Jin, Yong-Chi Ma & Zhi-Biao Liu. (2019) Correlations of MIF polymorphism and serum levels of MIF with glucocorticoid sensitivity of sudden sensorineural hearing loss . Journal of International Medical Research 48:4, pages 030006051989387.
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Adrien A. Eshraghi, David Shahal, Camron Davies, Jeenu Mittal, Viraj Shah, Erdogan Bulut, Carolyn Garnham, Priyanka Sinha, Dibyanshi Mishra, Hannah Marwede & Rahul Mittal. (2020) Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma. Journal of Clinical Medicine 9:3, pages 716.
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A. I. Kryukov, N. L. Kunelskaya, E. A. Shershunova, I. E. Rebrov, V. A. Yamshchikov, E. V. Garov, G. Yu. Tsarapkin & V. V. Mishchenko. (2019) Topical drug administration to the inner ear. Modern state of the problem and development perspectives. Vestnik otorinolaringologii 84:5, pages 6.
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Andrea Vambutas & Shresh Pathak. (2018) Monocytes, Macrophages, and Microglia and the Role of IL-1 in Autoimmune Inner Ear Disease (AIED). Current Otorhinolaryngology Reports 6:2, pages 203-208.
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Xiao Kuang, Yanhui Sun, Zhenjie Wang, Shuang Zhou & Hongzhuo Liu. (2018) A mitochondrial targeting tetrapeptide Bendavia protects lateral line hair cells from gentamicin exposure. Journal of Applied Toxicology 38:3, pages 376-384.
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Andrea Vambutas & Martin L. Lesser. 2018. Inflammatory Mechanisms in Mediating Hearing Loss. Inflammatory Mechanisms in Mediating Hearing Loss 211 223 .
Alanna M. Windsor & Michael J. Ruckenstein. 2018. Inflammatory Mechanisms in Mediating Hearing Loss. Inflammatory Mechanisms in Mediating Hearing Loss 189 210 .
Matthew Gordon Crowson, Ronna Hertzano & Debara L. Tucci. (2017) Emerging Therapies for Sensorineural Hearing Loss. Otology & Neurotology 38:6, pages 792-803.
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Shresh Pathak, Corey Stern & Andrea Vambutas. (2015) N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients. Immunologic Research 63:1-3, pages 236-245.
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P. Chrbolka, Z. Paluch & Š. Alušík. (2015) Current perspectives of tinnitus and its therapeutic options. European Geriatric Medicine 6:2, pages 170-174.
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Wong-Kein Christopher Low, Russel Kahmke & Debara L. Tucci. 2015. Free Radicals in ENT Pathology. Free Radicals in ENT Pathology 443 454 .
Wong Kein Low. (2013) Idiopathic Sudden Hearing Loss: Is There a Role for Complementary Treatment?. The Journal of Alternative and Complementary Medicine 19:9, pages 785-786.
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Benjamin PC Wei, Dimitra Stathopoulos & Stephen O'Leary. (2013) Steroids for idiopathic sudden sensorineural hearing loss. Cochrane Database of Systematic Reviews.
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Raphael Richard Ciuman. (2013) Inner ear symptoms and disease: Pathophysiological understanding and therapeutic options. Medical Science Monitor 19, pages 1195-1210.
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