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Audiology Volume 27, 1988 - Issue 3
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Original Article

Pharmacokinetics of Aminoglycoside Antibiotics in Blood, Inner-Ear Fluids and Tissues and Their Relationship to Ototoxicity

Review

Charles M. Henley Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Mich, USA
&
Jochen Schacht Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Mich, USA
Pages 137-146 | Received 22 Jan 1988, Accepted 08 Feb 1988, Published online: 07 Jul 2009

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Read on this site (4)

Min-Xin Guan. (2006) Mitochondrial DNA mutations associated with aminoglycoside ototoxicity. Audiological Medicine 4:4, pages 170-178.
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NATHAN FISCHEL-GHODSIAN. (2003) Mitochondrial Hearing Impairment. Audiological Medicine 1:1, pages 56-66.
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Tatsuya Hibi, Toru Suzuki, Tsutomu Nakashima. (2001) Perilymphatic Concentration of Gentamicin Administered Intratympanically in Guinea Pigs. Acta Oto-Laryngologica 121:3, pages 336-341.
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Tsutomu Nakashima, Masaaki Teranishi, Tatsuya Hibi, Masamichi Kobayashi, Masayuki Umemura. (2000) Vestibular and Cochlear Toxicity of Aminoglycosides - A review. Acta Oto-Laryngologica 120:8, pages 904-911.
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Articles from other publishers (61)

Cristina Salomón Felechosa, Jaime Gallo Terán & Carmelo Morales-Angulo. (2023) Ausencia de hipersensibilidad al efecto ototóxico de la gentamicina en un paciente portador de la mutación 1555A > G en el gen MT-RNR1. Acta Otorrinolaringológica Española 74:6, pages 403-405.
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Cristina Salomón Felechosa, Jaime Gallo Terán & Carmelo Morales-Angulo. (2023) Absence of hypersensitivity to the ototoxic effect of gentamicin in a patient carrying the 1555A > G mutation in the MT-RNR1 gene. Acta Otorrinolaringologica (English Edition) 74:6, pages 403-405.
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E. V. Shubnikova & N. Yu. Velts. (2023) Ototoxicity of Aminoglycosides the Modern Concepts. Antibiotics and Chemotherapy 67:11-12, pages 79-90.
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Muska Miller & Mervyn Singer. (2022) Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review. Journal of Antimicrobial Chemotherapy 77:5, pages 1218-1227.
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Sofía Ferreira-Cendon, Ramon Martinez-Carranza, Maria José Fernandez-Nava, Rosana Villaoslada-Fuente, Hortensia Sanchez-Gomez, Santiago Santa Cruz-Ruiz, María Sanchez-Ledesma & Angel Batuecas-Caletrio. (2022) Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin. Journal of Clinical Medicine 11:3, pages 586.
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Jonathan C. K. Quirke, Parasuraman Rajasekaran, Vikram A. Sarpe, Amr Sonousi, Ivan Osinnii, Marina Gysin, Klara Haldimann, Qiao-Jun Fang, Dimitri Shcherbakov, Sven N. Hobbie, Su-Hua Sha, Jochen Schacht, Andrea Vasella, Erik C. Böttger & David Crich. (2019) Apralogs: Apramycin 5- O -Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant . Journal of the American Chemical Society 142:1, pages 530-544.
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Amy E. Lindsey & Ellen Townes-Anderson. (2017) Antibiotics Reduce Retinal Cell Survival In Vitro. Neurotoxicity Research 33:4, pages 781-789.
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Katsuhiko Yoshitomi & Phaedra Cole. 2018. Boorman's Pathology of the Rat. Boorman's Pathology of the Rat 241 250 .
Catherine C. RiekeOdile H. ClavierLindsay V. AllenAllison P. AndersonChris A. BrooksAbigail M. FellowsDouglas S. BrungartJay C. Buckey. (2017) Fixed-Level Frequency Threshold Testing for Ototoxicity Monitoring. Ear & Hearing 38:6, pages e369-e375.
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C Lanvers‐Kaminsky, AG am Zehnhoff‐Dinnesen, R Parfitt & G Ciarimboli. (2017) Drug‐induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies. Clinical Pharmacology & Therapeutics 101:4, pages 491-500.
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Zewen Gao, Ye Chen & Min-Xin Guan. (2017) Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity. Journal of Otology 12:1, pages 1-8.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 216 236 .
Takahiko Matsushita, Weiwei Chen, Reda Juskeviciene, Youjin Teo, Dimitri Shcherbakov, Andrea Vasella, Erik C. Böttger & David Crich. (2015) Influence of 4′- O -Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin . Journal of the American Chemical Society 137:24, pages 7706-7717.
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Leonard P. Rybak & Michael J. Brenner. 2015. Free Radicals in ENT Pathology. Free Radicals in ENT Pathology 195 216 .
Jochen Schacht, Andra E. Talaska & Leonard P. Rybak. (2012) Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention. The Anatomical Record 295:11, pages 1837-1850.
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Bruce H. Cohen & Russell P. Saneto. (2012) Mitochondrial translational inhibitors in the pharmacopeia. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1819:9-10, pages 1067-1074.
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Eliana S. Armstrong, Corwin F. Kostrub, Robert T. Cass, Heinz E. Moser, Alisa W. Serio & George H. Miller. 2012. Antibiotic Discovery and Development. Antibiotic Discovery and Development 229 269 .
Min-Xin Guan. (2011) Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity. Mitochondrion 11:2, pages 237-245.
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Rashid Akbergenov, Dmitry Shcherbakov, Tanja Matt, Stefan Duscha, Martin Meyer, Déborah Perez Fernandez, Rashmi Pathak, Shinde Harish, Iwona Kudyba, Srinivas R. Dubbaka, Sandrina Silva, Maria del Carmen Ruiz Ruiz, Sumantha Salian, Andrea Vasella & Erik C. Böttger. 2011. Ribosomes. Ribosomes 249 261 .
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Edwin M. Monsell, Stephen P. Cass, Leonard P. Rybak & Julian M. Nedzelski. 2010. Otologic Surgery. Otologic Surgery 493 505 .
Yaping Qian & Min-Xin Guan. (2009) Interaction of Aminoglycosides with Human Mitochondrial 12S rRNA Carrying the Deafness-Associated Mutation. Antimicrobial Agents and Chemotherapy 53:11, pages 4612-4618.
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Andrew Forge, Ruth Taylor & Ernest S. Harpur. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Neil Howell & Corinna Howell. 2008. Drug‐Induced Mitochondrial Dysfunction. Drug‐Induced Mitochondrial Dysfunction 127 139 .
Leonard P. Rybak, Andra E. Talaska & Jochen Schacht. 2008. Auditory Trauma, Protection, and Repair. Auditory Trauma, Protection, and Repair 219 256 .
L.P. Rybak & V. Ramkumar. (2007) Ototoxicity. Kidney International 72:8, pages 931-935.
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Guan Min-Xin. (2006) Mitochondrial DNA Mutations Associated with Aminoglycoside Ototoxicity. Journal of Otology 1:2, pages 65-75.
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John Massie & Noel Cranswick. (2006) Pharmacokinetic profile of once daily intravenous tobramycin in children with cystic fibrosis. Journal of Paediatrics and Child Health 42:10, pages 601-605.
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Min-Xin Guan, Qingfeng Yan, Xiaoming Li, Yelena Bykhovskaya, Jaime Gallo-Teran, Petr Hajek, Noriko Umeda, Hui Zhao, Gema Garrido, Emebet Mengesha, Tsutomu Suzuki, Ignacio del Castillo, Jennifer Lynne Peters, Ronghua Li, Yaping Qian, Xinjian Wang, Ester Ballana, Mordechai Shohat, Jianxin Lu, Xavier Estivill, Kimitsuna Watanabe & Nathan Fischel-Ghodsian. (2006) Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations. The American Journal of Human Genetics 79:2, pages 291-302.
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Andra E. Talaska, Jochen Schacht & Nathan Fischel-Ghodsian. (2006) Molecular and genetic aspects of aminoglycoside-induced hearing loss. Drug Discovery Today: Disease Mechanisms 3:1, pages 119-124.
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. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 118 136 .
Nathan Fischel-Ghodsian. (2005) Genetic factors in aminoglycoside toxicity. Pharmacogenomics 6:1, pages 27-36.
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MIN-XIN GUAN. (2004) Molecular Pathogenetic Mechanism of Maternally Inherited Deafness. Annals of the New York Academy of Sciences 1011:1, pages 259-271.
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J. Gallo-Terán, B. Arellano, C. Morales-Angulo, S. Modamio-Høybjør, M. Á Moreno-Pelayo, R. Ramírez-Camacho, I. Del Castillo & F. Moreno. (2004) Prevalencia de la mutación a1555g en el adn mitocondrial en pacientes con patología auditiva o vestibular debida a la ototoxicidad de los aminoglucósidos. Acta Otorrinolaringológica Española 55:5, pages 212-217.
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Min-Xin Guan. 2004. Mitochondrial Pathogenesis. Mitochondrial Pathogenesis 259 271 .
Dalian Ding, Sandra L. McFadden, Richard W. Browne & Richard J. Salvi. (2003) Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells. Hearing Research 185:1-2, pages 90-96.
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Sandra L McFadden, Dalian Ding, Haiyan Jiang, Jenifer M Woo & Richard J Salvi. (2002) Chinchilla models of selective cochlear hair cell loss. Hearing Research 174:1-2, pages 230-238.
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Zoran Becvarovski, Elias M. Michaelides, Jack M. Kartush, Dennis I. Bojrab & Michael J. LaRouere. (2009) Rapid Elevation of Gentamicin Levels in the Human Labyrinth Following Intravenous Administration. The Laryngoscope 112:7, pages 1163-1165.
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NATHAN FISCHEL‐GHODSIAN. (2006) Genetic Factors in Aminoglycoside Toxicity. Annals of the New York Academy of Sciences 884:1, pages 99-109.
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H. David Humes. (2006) Insights into Ototoxicity. Annals of the New York Academy of Sciences 884:1, pages 15-18.
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J. L. Lancaster, S. Mortimore, M. McCormick & C. A. Hart. (1999) Systemic absorption of gentamicin in the management of active mucosal chronic otitis media. Clinical Otolaryngology and Allied Sciences 24:5, pages 435-439.
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Nathan Fischel-Ghodsian. (1999) Mitochondrial deafness mutations reviewed. Human Mutation 13:4, pages 261-270.
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DAN BAGGER-SJOBACK. (1997) Effect of Streptomycin and Gentamicin on the Inner Ear. Annals of the New York Academy of Sciences 830:1 Immunologic D, pages 120-129.
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Eric M. PriuskaJochen Schacht. (1997) Mechanism and Prevention of Aminoglycoside Ototoxicity: Outer Hair Cells as Targets and Tools. Ear, Nose & Throat Journal 76:3, pages 164-172.
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Charles M. Henley, Robert A. Weatherly, Ching-Nan Ou & R. Don Brown. (1996) Pharmacokinetics of kanamycin in the developing rat. Hearing Research 99:1-2, pages 85-90.
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P J Wood, L L Ioannides-Demos, S C Li, T J Williams, B Hickey, W J Spicer, R E Hooper & A J McLean. (1996) Minimisation of aminoglycoside toxicity in patients with cystic fibrosis.. Thorax 51:4, pages 369-373.
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Tapan K. Bhattacharyya & Vijay S. Dayal. (1991) Potentiation of cochlear hair cell loss by acoustic stimulus and gentamicin in the guinea pig. The Anatomical Record 230:1, pages 136-145.
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Paul Nikolaidis, Stephen Vas, Victor Lawson, Lorraine Kennedy-Vosu, April Bernard, Georgi Abraham, Sharon Izatt, Sudhir Khanna, Joanne M. Bargman & Dimitrios G. Oreopoulos. (2020) Is Intraperitoneal Tobramycin Ototoxic in CAPD Patients?. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 11:2, pages 156-161.
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