Pharmacokinetics of Aminoglycoside Antibiotics in Blood, Inner-Ear Fluids and Tissues and Their Relationship to Ototoxicity

References

• Balogh K., Hiraide R, Ishii D. Distribution of radioactive dihydrostreptomycin in the cochlea. Ann. Otol. Rhinol. Lar. 1970; 79: 641–652
   PubMed Web of Science ®Google Scholar
• Barza M., Scheife R. T. Antimicrobial spectrum, pharmacology, and therapeutic use of antibiotics. J. Maine med. Ass. 1977; 68: 194–210
   PubMedGoogle Scholar
• Brier M. E., Mayer P. R., Brier R. A., Visscher D., Luft F.C, Aronoff G. R. Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities. Antimicrob. Agents Chemother. 1985; 27: 812–816
   PubMedGoogle Scholar
• Brion N., Barge J., Godefroy I., Dromer R, Dubois C., Contrepois A., Carbon C. Gentamicin, netilmicin, dibekacin, and amikacin nephrotoxicity and its relationship to tubular reabsorption in rabbits. Antimicrob. Agents Chemother. 1984; 25: 168–172
   PubMed Web of Science ®Google Scholar
• Brummett R. E., Fox K. E. Studies of aminoglycoside ototoxicity in animal models. Whelton, Neu, The aminoglycosides. Microbiology, clinical use and toxicology pp. 419–451. Dekker, New York 1982
   Google Scholar
• Brummett R. E., Fox K. E., Bendrick T. W., Himes D. L. Ototoxicity of tobramycin, gentamicin, amikacin and sisomicin in the guinea pig. J. antimicrob. Chemother. 1978a; 4: 73–83
   PubMed Web of Science ®Google Scholar
• Brummett R. E., Fox K. E., Brown R. T., Himes D. L. Comparative ototoxic liability of netilmicin and gentamicin. Archs Otolar 1978b; 104: 579–584
   PubMed Web of Science ®Google Scholar
• Burn P., Rotman A., Meyer R. K., Burger M. M. Diacylglycerol in large actinin/actin complexes and in the cytoskeleton of activated platelets. Nature, Lond. 1985; 314: 469–472
   PubMed Web of Science ®Google Scholar
• Buss W. C., Kauten R., Piatt M. K. Inhibitory effects of gentamicin and ethacrynic acid on mammalian microsomal protein synthesis. J. antimicrob. Chemother. 1985; 15: 105–113
   PubMedGoogle Scholar
• Buss W. C., Piatt M. K., Kauten R. Inhibition of mammalian microsomal protein synthesis by aminoglycoside antibiotics. J. antimicrob. Chemother. 1984; 14: 231–241
   PubMedGoogle Scholar
• Cojocel C., Docius N., Maita K., Smith J. H., Hook J. B. Renal ultrastructural and biochemical injuries induced by aminoglycosides. Environ. Health Perspect. 1984; 57: 293–299
   PubMed Web of Science ®Google Scholar
• Dahlgren J. G., Anderson E. T., Hewitt W. L. Gentamicin blood levels: a guide to nephrotoxicity. Antimicrob. Agents Chemother. 1975; 8: 58–62
   PubMed Web of Science ®Google Scholar
• Davis R. R., Brummett R. E., Bendrick T. W., Himes D. L. Dissociation of maximum concentrations of kanamycin in plasma and perilymph from ototoxic effect. J. antimicrob. Chemother. 1984; 14: 291–302
   PubMed Web of Science ®Google Scholar
• Desjardins-Giasson S., Beaubien A. R. Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs. Antimicrob. Agents Chemother. 1984; 26: 87–90
   PubMedGoogle Scholar
• Desrochers C. S., Schacht J. Neomycin concentrations in inner ear tissues and other organs of the guinea pig after chronic drug administration. Acta oto-lar. 1982; 93: 233–236
   PubMed Web of Science ®Google Scholar
• Dulon D, Aran J.-M., Zajic G., Schacht J. Comparative uptake of gentamicin, netilmicin and amikacin in the guinea pig cochlea and vestibule. Antimicrob. Agents Chemother. 1986; 30: 96–100
   PubMed Web of Science ®Google Scholar
• Escoubet B., Amsallem P., Ferrary E., Tran Ba Huy P. Prostaglandin synthesis by the cochlea of the guinea pig.Influence of aspirin, gentamicin and acoustic stimulation. Prostaglandins 1985; 29: 589–599
   PubMed Web of Science ®Google Scholar
• Federspil P. Pharmacokinetics of aminoglycoside antibiotics in perilymph. Lerner, Matz, Hawkins, Aminoglycoside ototoxicity. Little, Brown, Boston 1981; 90–110
   Google Scholar
• Federspil P., Schätzle W., Tiesler E. Pharmacokinetics and ototoxicity of gentamicin, tobramycin and amikacin. J. infect. Dis. 1976; 134: 200–205
   Web of Science ®Google Scholar
• Fox K. E., Brummett R. E. The relationship between the cytotoxicity of kanamycin and ethacrynic acid for mammalian cells in vitro and their toxicity in vivo. Acta oto-lar. 1979; 87: 72–78
   PubMed Web of Science ®Google Scholar
• Fox K. E., Brummett R. E., Brown R., Himes D. A comparative study of the ototoxicity of gentamicin and gentamicin Q. Archs Otolar 1980; 106: 744–750
   PubMedGoogle Scholar
• Gatell J. M., San Miguel J. G., Zamora L., Araujo V., Bonet M., Bohe M., Jimenez de Anta MX, Farre M., Elena M., Ballesta A., Marin J. L. Comparison of nephrotoxicity and auditory toxicity of tobramycin and amikacin. Antimicrob. Agents Chemother. 1983; 23: 897–901
   PubMedGoogle Scholar
• Hayashida T., Nomura Y., Iwamori M., Nagai Y., Kurata T. Distribution of gentamicin by immunofluorescence in the guinea pig inner ear. Archs Oto-Rhino-Lar. 1985; 242: 257–264
   PubMedGoogle Scholar
• Henley C. M., Gerhardt H.-J., Schacht J. Inhibition of inner ear ornithine decarboxylase by neomycin in vitro. Brain Res. Bull. 1987; 19: 695–698
   PubMedGoogle Scholar
• Henley C. M., Mahran L. G., Schacht J. Inhibition of renal ornithine decarboxylase by aminoglycosides in vitro. Biochem. Pharmac., in press
   Google Scholar
• Hewitt W. L. Gentamicin: toxicity in perspective. Post-grad, med. J. 1974; 50: 55–59
   PubMed Web of Science ®Google Scholar
• Humes H. D., Weiner N. D., Schacht J. The biochemical pathology of aminoglycoside induced nephro-and ototoxicity; Fillastre, Nephrotoxicity and ototoxicity of drugs. INSERM, Paris 1982; 333–343
   Google Scholar
• Josepovitz C, Pastoriza-Munoz E., Timmerman D., Scott M., Feldman S., Kaloyanides G. J. Inhibition of gentamicin uptake in rat renal cortex in vivo by aminoglycosides and organic polycations. J. Pharmacol, exp. Ther. 1982; 223: 314–321
   PubMed Web of Science ®Google Scholar
• Kaloyanides G. J. Aminoglycoside-induced functional and biochemical defects in the renal cortex. Fun-dam, appl. Toxicol. 1984; 4: 930–943
   PubMedGoogle Scholar
• Kornguth M. L., Bayer W. H., Kunin C. M. Binding of gentamicin to subcellular fractions of rabbit kidney: inhibition by spermine and other polyamines. J. antimicrob. Chemother. 1980; 6: 121–131
   PubMedGoogle Scholar
• Larsson B., Nilsson M., Tjälve H. The tissue disposition of gentamicin in rats. Acta pharmaco. tox. 1981; 48: 269–278
   Google Scholar
• Lassing I., Lindberg U. Specific interaction between phosphatidylinositol 4,5–bisphosphate and profilactin. Nature, Lond. 1985; 314: 472–474
   PubMedGoogle Scholar
• Meyer R. D. Amikacin. Ann. intern. Med. 1981; 95: 328–332
   PubMedGoogle Scholar
• Muraveiskaya V. S. Determination of streptomycin, dihydrostreptomycin, colimycin, and monomycin concentrations in labyrinth fluid of guinea pigs. Antibiotiki 1965; 10: 245
   PubMedGoogle Scholar
• Ohtani I., Ohtsuki K., Aikawa T, Sato Y., Anzai T, Ouchi J., Saito J. Low ototoxicity and its mechanism of netilmicin. ORL 1985; 47: 84–89
   Google Scholar
• Ohtsuki K., Ohtani I., Aikawa X, Sato Y, Anzai T, Ouchi J., Saito T. The ototoxicity and the accumulation in the inner ear of the various aminoglycoside antibiotics. Ear Res. Jap. 1982; 13: 85–87
   Google Scholar
• Plaut M. E., Schentag J. J., Jusko W. J. Aminoglycoside nephrotoxicity: comparative assessment in critically ill patients. J. Med. 1979; 10: 257–266
   PubMedGoogle Scholar
• Portmann M., Darrouzet J., Coste C. Distribution within the cochlea of dihydrostreptomycin injected into the circulation. Archs Otolar 1974; 100: 473–475
   PubMedGoogle Scholar
• Russell D. H. Ornithine decarboxylase: a key regulatory enzyme in normal and neoplastic growth. Drug Metab. Rev. 1985; 16: 1–88
   PubMed Web of Science ®Google Scholar
• Sarubbi F. A., Jr., Hull J. H. Amikacin serum concentrations: prediction of levels and dosage guidelines. Ann. intern. Med. 1978; 89: 612–618
   PubMed Web of Science ®Google Scholar
• Schacht J. Interaction of neomycin with phosphoinositide metabolism in guinea pig inner ear and brain tissues. Ann. Otol. Rhinol. Lar. 1974; 83: 613–618
   PubMed Web of Science ®Google Scholar
• Schacht J. Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney. Archs Oto-Rhino-Lar. 1979; 224: 129–134
   PubMedGoogle Scholar
• Schacht J. Molecular mechanism of drug-induced hearing loss. Hearing Res 1986; 22: 297–304
   PubMed Web of Science ®Google Scholar
• Strauss P., Rosin H., Quante M., Harari G., Winter V., Lobner S. Gentamycin im Verteilungsgleich-gewicht zwischen Serum, Perilymphe und Liquor beim Meerschweinchen nach Dosierung im thera-peutischen Bereich. Archs Oto-Rhino-Lar. 1977; 218: 79–86
   PubMedGoogle Scholar
• Stupp H. F. Untersuchung der Antibiotikaspiegel in den Innenohrflilssigkeiten und ihre Bedeutung filr die spezifische Ototoxizitat der Aminoglykosidan-tibiotika. Acta oto-lar. 1970; 1–85, suppl. 262
   Google Scholar
• Stupp H., Kupper K., Lagler E, Sous H., Quante M. Inner ear concentrations and ototoxicity of different antibiotics in local and systemic application. Audiology 1973; 12: 350–363
   PubMedGoogle Scholar
• Tammela M. N., Tjalve H. Whole-body autoradiography of [3H]-dihydrostreptomycin in guinea pigs and rats: the labelling of the inner ear in relation to other tissues. Acta oto-lar. 1986; 101: 247–256
   PubMed Web of Science ®Google Scholar
• Tran Ba Huy P., Bernard P., Schacht J. Kinetics of gentamicin uptake and release in the rat: comparison of inner ear tissues and fluids with other organs. J. clin. Invest. 1986; 77: 1492–1500
   PubMed Web of Science ®Google Scholar
• Tran Ba Huy P., Manuel C, Meulemans A., Sterkers O., Amiel C. Pharmacokinetics of gentamicin in perilymph and endolymph of the rat as determined by radioimmunoassay. J. infect. Dis. 1981; 143: 476–486
   PubMed Web of Science ®Google Scholar
• Voldrich L. The kinetics of streptomycin, kanamycin, and neomycin in the inner ear. Acta oto-lar. 1965; 60: 243–248
   PubMedGoogle Scholar
• von Ilberg C, Spoendlin H., Arnold W. Autoradio-graphical distribution of locally applied dihydrostreptomycin in the inner ear. Acta oto-lar. 1971; 71: 159–165
   PubMed Web of Science ®Google Scholar
• Vrabec D. P., Cody D. T., Ultrich J. A. A study of the relative concentrations of antibiotics in the blood, spinal fluid and perilymph in animals. Ann. Otol. Rhinol. Lar. 1965; 74: 688–705
   Web of Science ®Google Scholar
• Wagner W. H., Chou J. T.Y., von Ilberg C, Ritter R., Vosteen K. H. Untersuchungen zur Pharmakokinetik von Streptomycin. Drug Res 1971; 21: 2006–2016
   PubMed Web of Science ®Google Scholar
• Wang B. M., Weiner N. D., Takada A., Schacht J. Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing. Biochem. Pharmac. 1984; 33: 3257–3262
   PubMed Web of Science ®Google Scholar
• Watanabe Y., Nakajima R., Oda R., Uno M., Naito T. Experimental study on the transfer of kanamycin to the inner ear fluids. Med. J. Osaka Univ. 1971; 21: 257–263
   PubMedGoogle Scholar
• Williams S. E., Schacht J. Binding of neomycin and calcium to phospholipids and other anionic compounds. J. Antibio. 1986; 39: 457–462
   PubMedGoogle Scholar
• Williams S. E., Smith D. E., Schacht J. Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig. Biochem. Pharmac. 1987; 36: 89–95
   PubMedGoogle Scholar