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Research Article

Serum osteocalcin levels in patients with nonalcoholic fatty liver disease: Association with ballooning degeneration

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Pages 631-636 | Received 14 May 2011, Accepted 01 Jun 2011, Published online: 22 Aug 2011

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Yu-Jie Wang, Chun-Hua Jin, Jiang-Feng Ke, Jun-Wei Wang, Yi-Lin Ma, Jun-Xi Lu, Mei-Fang Li & Lian-Xi Li. (2022) Decreased Serum Osteocalcin is an Independent Risk Factor for Metabolic Dysfunction-Associated Fatty Liver Disease in Type 2 Diabetes. Diabetes, Metabolic Syndrome and Obesity 15, pages 3717-3728.
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Yue Sun, Weiran Dai, Yuzhen Liang, Pijian Yang, Qiong Yang, Min Liang & Ning Xia. (2019) Relationship between nonalcoholic fatty liver disease and bone mineral density in adolescents with obesity: a meta-analysis. Diabetes, Metabolic Syndrome and Obesity 12, pages 199-207.
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Rafał Filip, Radosław P Radzki & Marek Bieńko. (2018) Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis. Clinical Interventions in Aging 13, pages 1879-1891.
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Yusuf Yilmaz, Fatih Eren, Yasar Colak, Ebubekir Senates, Cigdem Ataizi Celikel & Nese Imeryuz. (2012) Hepatic expression and serum levels of syndecan 1 (CD138) in patients with nonalcoholic fatty liver disease. Scandinavian Journal of Gastroenterology 47:12, pages 1488-1493.
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Articles from other publishers (29)

Mohamed M. Elseweidy, Abd El-Monem Ali, Sara M. Hassanin & Yasmin K. Mahmoud. (2023) Empagliflozin ameliorates liver fibrosis in NASH rat model via targeting hepatic NF-κB/SOX9/OPN signaling and osteocalcin level. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Chao Li, Yali Cui, Wenjie Zhou, Yiduo Zhang, Xiaocui Huang & Fan Yu. (2023) Bone Turnover Markers in Adults with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. International Journal of Endocrinology 2023, pages 1-9.
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Anika Shimonty, Lynda F. Bonewald & Joshua R. Huot. (2023) Metabolic Health and Disease: A Role of Osteokines?. Calcified Tissue International 113:1, pages 21-38.
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M. Zhang, W.J. Tu, Q. Zhang, X.L. Wu, X.Y. Zou & S. Jiang. (2022) Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes. Poultry Science 101:11, pages 102026.
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Alexandra-Diana Diaconu, Alexandr Ceasovschih, Victorița Șorodoc, Cristina Pomîrleanu, Cătălina Lionte, Laurențiu Șorodoc & Codrina Ancuța. (2022) Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis. International Journal of Molecular Sciences 23:19, pages 11561.
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J. Fu, Z. Mu, L. Sun, X. Gao, X. Hu & S. Xiu. (2022) Chinese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease have lower serum osteocalcin levels compared to individuals with type 2 diabetes mellitus and no liver disease: a single-center cross-sectional study. Journal of Endocrinological Investigation 45:12, pages 2275-2282.
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Zhijie Xu, Pengyuan He, Jianzhong Xian, Wuzhu Lu, Jingxian Shu, Wentao Luo, Chongjie Gan, Ruoman Ke, Jinyu Xia, Zongping Han & Mingxing Huang. (2021) Association between Nonalcoholic Fatty Liver Disease and Bone Mineral Density in HIV-Infected Patients Receiving Long-term TDF-Based Antiretroviral Therapy. Current HIV Research 19:1, pages 40-46.
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Yinghua He, Jianping Jiang, Beihui He & Zheng Shi. (2021) Chemical Activators of the Nrf2 Signaling Pathway in Nonalcoholic Fatty Liver Disease. Natural Product Communications 16:1, pages 1934578X2098709.
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Takahito Otani, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Hiroshi Takeuchi, Tetsuichiro Inai & Masato Hirata. (2020) The roles of osteocalcin in lipid metabolism in adipose tissue and liver. Advances in Biological Regulation 78, pages 100752.
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Bin Teng, Chen Huang, Chuan-Li Cheng, Anjaneyulu Udduttula, Xiang-Fang Yu, Chang Liu, Jian Li, Zhen-Yu Yao, Jing Long, Li-Fu Miao, Chao Zou, Jun Chu, Jian V. Zhang & Pei-Gen Ren. (2020) Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A. Journal of Hepatology 73:2, pages 383-393.
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Ningjian Wang, Yuying Wang, Xiaoman Chen, Wen Zhang, Yi Chen, Fangzhen Xia, Heng Wan, Qing Li, Boren Jiang, Bin Hu & Yingli Lu. (2020) Bone Turnover Markers and Probable Advanced Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Men and Postmenopausal Women With Type 2 Diabetes. Frontiers in Endocrinology 10.
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Yujiao Han, Xiuling You, Wenhui Xing, Zhong Zhang & Weiguo Zou. (2018) Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research 6:1.
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Jessica Bonneau, Guylaine Ferland, Antony D. Karelis, Éric Doucet, May Faraj, Rémi Rabasa-Lhoret & Mathieu Ferron. (2017) Association between osteocalcin gamma-carboxylation and insulin resistance in overweight and obese postmenopausal women. Journal of Diabetes and its Complications 31:6, pages 1027-1034.
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Eleonora Poggiogalle, Lorenzo Maria Donini, Andrea Lenzi, Claudio Chiesa & Lucia Pacifico. (2017) Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle. World Journal of Gastroenterology 23:10, pages 1747.
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Jing Du, Mingliang Zhang, Junxi Lu, Xueli Zhang, Qin Xiong, Yiting Xu, Yuqian Bao & Weiping Jia. (2016) Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK. Endocrine 53:3, pages 701-709.
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Hae Jin Yang, Sang Goon Shim, Bong Oh Ma & Ji Yeong Kwak. (2016) Association of nonalcoholic fatty liver disease with bone mineral density and serum osteocalcin levels in Korean men. European Journal of Gastroenterology & Hepatology 28:3, pages 338-344.
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Yu-qi Luo, Xiao-jing Ma, Ya-ping Hao, Xiao-ping Pan, Yi-ting Xu, Qin Xiong, Yu-qian Bao & Wei-ping Jia. (2015) Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels. Acta Pharmacologica Sinica 36:12, pages 1497-1502.
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G. Targher, A. Lonardo & M. Rossini. (2015) Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?. Journal of Endocrinological Investigation 38:8, pages 817-825.
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Yanqiong Liu, Liying Huang, Yu Lu, Xue-E Xi, Xiu-Li Huang, Qinghua Lu, Xiamei Huang, Shan Li & Xue Qin. (2015) Relationships between the Osteocalcin Gene Polymorphisms, Serum Osteocalcin Levels, and Hepatitis B Virus-Related Hepatocellular Carcinoma in a Chinese Population. PLOS ONE 10:1, pages e0116479.
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Dong Hyun Sinn, Geum-Youn Gwak, Sang Youl Rhee, Juhee Cho, Hee Jung Son, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Byung Chul Yoo & Seung Woon Paik. (2015) Association between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Women. Digestion 91:2, pages 150-157.
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Anisha A. Gupte, Omaima M. Sabek, Daniel Fraga, Laurie J. Minze, Satoru K. Nishimoto, Joey Z. Liu, Solmaz Afshar, Lillian Gaber, Christopher J. Lyon, A. Osama Gaber & Willa A. Hsueh. (2014) Osteocalcin Protects Against Nonalcoholic Steatohepatitis in a Mouse Model of Metabolic Syndrome. Endocrinology 155:12, pages 4697-4705.
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Mathieu Ferron & Julie Lacombe. (2014) Regulation of energy metabolism by the skeleton: Osteocalcin and beyond. Archives of Biochemistry and Biophysics 561, pages 137-146.
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Jun-Jie Liu, Yuan-Yuan Chen, Zeng-Nan Mo, Gui-Xiang Tian, Ai-Hua Tan, Yong Gao, Xiao-Bo Yang, Hai-Ying Zhang & Zhi-Xian Li. (2013) Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China. International Journal of Molecular Sciences 14:10, pages 19782-19791.
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Giovanni Musso, Elena Paschetta, Roberto Gambino, Maurizio Cassader & Federica Molinaro. (2013) Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver. Trends in Molecular Medicine 19:9, pages 522-535.
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Jianxin Dou, Xiaojing Ma, Qichen Fang, Yaping Hao, Rong Yang, Feifei Wang, Jiaan Zhu, Yuqian Bao & Weiping Jia. (2013) Relationship between serum osteocalcin levels and non‐alcoholic fatty liver disease in Chinese men. Clinical and Experimental Pharmacology and Physiology 40:4, pages 282-288.
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Ran Cui, Hui Sheng, Xue-Fei Rui, Xiao-Yun Cheng, Chun-Jun Sheng, Ji-Ying Wang & Shen Qu. (2013) Low Bone Mineral Density in Chinese Adults with Nonalcoholic Fatty Liver Disease. International Journal of Endocrinology 2013, pages 1-6.
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Yusuf Yilmaz, Oguzhan Ozturk, Yesim Ozen Alahdab, Ebubekir Senates, Yasar Colak, Hamdi Levent Doganay, Ender Coskunpinar, Yasemin Musteri Oltulu, Fatih Eren, Ozlen Atug, Ilyas Tuncer & Nese Imeryuz. (2013) Serum osteopontin levels as a predictor of portal inflammation in patients with nonalcoholic fatty liver disease. Digestive and Liver Disease 45:1, pages 58-62.
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Yusuf Yilmaz & Fatih Eren. (2012) Identification of a support vector machine-based biomarker panel with high sensitivity and specificity for nonalcoholic steatohepatitis. Clinica Chimica Acta 414, pages 154-157.
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Y. Yilmaz. (2012) Review article: non‐alcoholic fatty liver disease and osteoporosis – clinical and molecular crosstalk. Alimentary Pharmacology & Therapeutics 36:4, pages 345-352.
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