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Scandinavian Journal of Gastroenterology Volume 50, 2015 - Issue 2
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Original Article

Randomized clinical trial: efficacy and safety of PPC-5650 on experimental esophageal pain and hyperalgesia in healthy volunteers

Anne Estrup OlesenMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark;Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
,
Lecia Møller NielsenMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark;Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
,
Isabelle Myriam LarsenMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
&
Asbjørn Mohr DrewesMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark;Clinical Institute, Aalborg University Hospital, Aalborg, Denmark
Pages 138-144 | Received 15 Aug 2014, Accepted 10 Sep 2014, Published online: 08 Dec 2014

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Catherine J. Hutchings, Paul Colussi & Theodore G. Clark. (2019) Ion channels as therapeutic antibody targets. mAbs 11:2, pages 265-296.
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Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Ashraf Aboelela, Richard S. Bujaroski, Hiwa Majed, Alejandra Rangel, David J. Adams, Marie Ranson, Michael J. Kelso & Benjamin J. Buckley. (2023) Automated Patch Clamp Screening of Amiloride and 5- N , N -Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor . Molecular Pharmaceutics 20:7, pages 3367-3379.
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Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia & Anne Baron. (2022) Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects. Toxins 14:10, pages 709.
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Stephanie A. Heusser & Stephan A. Pless. (2021) Acid-sensing ion channels as potential therapeutic targets. Trends in Pharmacological Sciences 42:12, pages 1035-1050.
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Dalila Mango & Robert Nisticò. (2021) Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?. Frontiers in Cellular Neuroscience 15.
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Cosmin I. Ciotu & Michael J. M. Fischer. (2020) Novel Analgesics with Peripheral Targets. Neurotherapeutics 17:3, pages 784-825.
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Dalila Mango & Robert Nisticò. 2020. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 83 100 .
Lachlan D. Rash. 2017. Ion Channels DownUnder. Ion Channels DownUnder 35 66 .
M.O. Martel, A.E. Olesen, D. Jørgensen, L.M. Nielsen, C. Brock, R.R. Edwards & A.M. Drewes. (2016) Does catastrophic thinking enhance oesophageal pain sensitivity? An experimental investigation. European Journal of Pain 20:8, pages 1214-1222.
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Gordon Munro. (2016) Novel Translational Approaches for Improving Drug Discovery Efforts in Chronic Pain. CNS Neuroscience & Therapeutics 22:2, pages 85-87.
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Gordon Munro, Jeppe K. Christensen, Helle K. Erichsen, Tino Dyhring, Joachim Demnitz, Eva Dam & Philip K. Ahring. (2016) NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neuroscience & Therapeutics 22:2, pages 135-145.
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