References
- Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005;54:710–17.
- Lottrup C, Olesen SS, Drewes AM. The pain system in oesophageal disorders: Mechanisms, clinical characteristics, and treatment. Gastroenterol Res Pract 2011;2011:910420.
- Drewes AM, Gregersen H. Multimodal pain stimulation of the gastrointestinal tract. World J Gastroenterol 2006;12:2477–86.
- Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J. Esophageal sensation and esophageal hypersensitivity - overview from bench to bedside. J Neurogastroenterol Motil 2010;16:353–62.
- Deval E, Gasull X, Noel J, Salinas M, Baron A, Diochot S, et al. Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther 2010;128:549–58.
- Emerenziani S, Ribolsi M, Guarino MP, Balestrieri P, Altomare A, Rescio MP, et al. Acid reflux episodes sensitize the esophagus to perception of weakly acidic and mixed reflux in non-erosive reflux disease patients. Neurogastroenterol Motil 2014;26:108–14.
- Dube GR, Elagoz A, Mangat H. Acid sensing ion channels and acid nociception. Curr Pharm Des 2009;15:1750–66.
- PPC 5650 potential for inflammatory pain treatment. Inpharma Wkly 2008;1656:10.
- Drewes AM, Gregersen H, Arendt-Nielsen L. Experimental pain in gastroenterology: a reappraisal of human studies. Scand J Gastroenterol 2003;38:1115–30.
- Olesen AE, Staahl C, Arendt-Nielsen L, Drewes AM. Different effects of morphine and oxycodone in experimentally evoked hyperalgesia: a human translational study. Br J Clin Pharmacol 2010;70:189–200.
- Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 2005;113:9–19.
- Drewes AM, Pedersen J, Liu W, Arendt-Nielsen L, Gregersen H. Controlled mechanical distension of the human oesophagus: sensory and biomechanical findings. Scand J Gastroenterol 2003;38:27–35.
- Arendt-Nielsen L, Olesen AE, Staahl C, Menzaghi F, Kell S, Wong GY, et al. Analgesic efficacy of peripheral kappa opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: Selective effect on visceral pain. Anesthesiology 2009;111:616–24.
- Staahl C, Reddy H, Andersen SD, Arendt-Nielsen L, Drewes AM. Multi-modal and tissue-differentiated experimental pain assessment: reproducibility of a new concept for assessment of analgesics. Basic Clin Pharmacol Toxicol 2006;98:201–11.
- Olesen AE, Staahl C, Brock C, Arendt-Nielsen L, Drewes AM. Evoked human oesophageal hyperalgesia: A potential tool for analgesic evaluation? Basic Clin Pharmacol Toxicol 2009;105:126–36.
- Krarup AL, Simren M, Funch-Jensen P, Hansen MB, Hvid-Jensen F, Brun J, et al. The esophageal multimodal pain model: normal values and degree of sensitization in healthy young male volunteers. Dig Dis Sci 2011;56:1967–75.
- Nielsen LM, Olesen AE, Andresen T, Simren M, Tornblom H, Drewes AM. Efficacy and safety of PPC-5650 on experimental rectal pain in patients with irritable bowel syndrome. Basic Clin Pharmacol Toxicol 2014; Epub ahead of print.
- Bulsiewicz WJ, Shaheen NJ, Hansen MB, Pruitt A, Orlando RC. Effect of amiloride on experimental acid-induced heartburn in non-erosive reflux disease. Dig Dis Sci 2013;58:1955–9.