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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 10-11: Special Issue: Modelling and Simulation Approaches to in vitro-in vivo Extrapolation of ADME Properties in Drug Development
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Research Article

In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects

P. J. H. Webborn Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, UK
,
A. J. Parker Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, UK
,
R. L. Denton Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, UK
&
R. J. Riley Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, UK
Pages 1090-1109 | Received 30 Apr 2007, Accepted 05 Jul 2007, Published online: 05 Jan 2010

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Sherri A. Smith, Sandra Gagnon & Nigel J. Waters. (2017) Mechanistic investigations into the species differences in pinometostat clearance: impact of binding to alpha-1-acid glycoprotein and permeability-limited hepatic uptake. Xenobiotica 47:3, pages 185-193.
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Mohd Yaseen Malik, Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla & Jawahar Lal. (2016) Role of enterohepatic recirculation in drug disposition: cooperation and complications. Drug Metabolism Reviews 48:2, pages 281-327.
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Thomas R. B. Grandjean, Mike J. Chappell, Alex M. Lench, James W. T. Yates & Charles J. O’Donnell. (2014) Experimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species. Xenobiotica 44:11, pages 961-974.
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Hyun-Jong Cho, Ji-Eon Kim, Dae-Duk Kim & In-Soo Yoon. (2014) In vitro–in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: principles and applications. Drug Development and Industrial Pharmacy 40:8, pages 989-998.
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Ling Li, Amr Nouraldeen & Alan G. E. Wilson. (2013) Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect. Xenobiotica 43:3, pages 253-262.
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A. Ayrton & P. Morgan. (2008) Role of transport proteins in drug discovery and development: a pharmaceutical perspective. Xenobiotica 38:7-8, pages 676-708.
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María José Gómez-Lechón, José V Castell & María Teresa Donato. (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 837-854.
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Christoph Funk. (2008) The role of hepatic transporters in drug elimination. Expert Opinion on Drug Metabolism & Toxicology 4:4, pages 363-379.
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Articles from other publishers (7)

Anne‐Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning & Stefanie Hessel‐Pras. (2021) Organic Cation Transporter I and Na + /taurocholate Co‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells . Molecular Nutrition & Food Research 66:2, pages 2100800.
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Paresh P. Chothe, Shu-Pei Wu, Zhengqi Ye & Niresh Hariparsad. (2018) Assessment of Transporter-Mediated and Passive Hepatic Uptake Clearance Using Rifamycin-SV as a Pan-Inhibitor of Active Uptake. Molecular Pharmaceutics 15:10, pages 4677-4688.
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Kyunghee Yang, Cen Guo, Jeffrey L. Woodhead, Robert L. St. ClaireIIIIII, Paul B. Watkins, Scott Q. Siler, Brett A. Howell & Kim L.R. Brouwer. (2016) Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury. Journal of Pharmaceutical Sciences 105:2, pages 443-459.
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Nynke I. Kramer, Emma Di Consiglio, Bas J. Blaauboer & Emanuela Testai. (2015) Biokinetics in repeated-dosing in vitro drug toxicity studies. Toxicology in Vitro 30:1, pages 217-224.
Crossref
J.P. Keogh. 2012. Current Concepts in Drug Metabolism and Toxicology. Current Concepts in Drug Metabolism and Toxicology 1 42 .
Olavi Pelkonen, Miia Turpeinen & Hannu Raunio. (2011) In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development. Clinical Pharmacokinetics 50:8, pages 483-491.
Crossref
Christopher Kohl. (2009) Transporters – The View from Industry. Chemistry & Biodiversity 6:11, pages 1988-1999.
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