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Li Di. (2021) An update on the importance of plasma protein binding in drug discovery and development. Expert Opinion on Drug Discovery 16:12, pages 1453-1465.
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Hannah M Eggink, Maarten R Soeters & Thijs WH Pols. (2014) TGR5 ligands as potential therapeutics in inflammatory diseases. International Journal of Interferon, Cytokine and Mediator Research 6, pages 27-38.
Read now
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M. Jason Hatfield & Philip M. Potter. (2011) Carboxylesterase inhibitors. Expert Opinion on Therapeutic Patents 21:8, pages 1159-1171.
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Articles from other publishers (47)
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley & Tung-Hu Tsai. (2023) Biotransformation and brain distribution of the anti-COVID-19 drug molnupiravir and herb-drug pharmacokinetic interactions between the herbal extract Scutellaria formula-NRICM101. Journal of Pharmaceutical and Biomedical Analysis 234, pages 115499.
Crossref
Crossref
Bing Yang, Robert B. Parker, Bernd Meibohm, Zaid H. Temrikar, Ashish Srivastava & S. Casey Laizure. (2022) Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis. PLOS ONE 17:11, pages e0278111.
Crossref
Crossref
Eun-yeong Kim, Bit Lee, Sangil Kwon, Timothy W. Corson, Seung-Yong Seo & Kiho Lee. (2022) Mouse Pharmacokinetics and In Vitro Metabolism of SH-11037 and SH-11008, Synthetic Homoisoflavonoids for Retinal Neovascularization. Pharmaceutics 14:11, pages 2270.
Crossref
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Dale J. Calleja, Nathan Kuchel, Bernadine G. C. Lu, Richard W. Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P. Cooney, Liana Mackiewicz, Amanda E. Au, Yu Q. Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E. Jarman, Melissa J. Call, Bernhard C. Lechtenberg, Peter E. Czabotar, Marc Pellegrini, Susan A. Charman, Kym N. Lowes, Jeffrey P. Mitchell, Ueli Nachbur, Guillaume Lessene & David Komander. (2022) Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. Frontiers in Chemistry 10.
Crossref
Crossref
Florian Brandt, Martin Ullrich, Markus Laube, Klaus Kopka, Michael Bachmann, Reik Löser, Jens Pietzsch, Hans-Jürgen Pietzsch, Jörg van den Hoff & Robert Wodtke. (2021) “Clickable” Albumin Binders for Modulating the Tumor Uptake of Targeted Radiopharmaceuticals. Journal of Medicinal Chemistry 65:1, pages 710-733.
Crossref
Crossref
Meng-meng Zhang, Peng Li, Feng Hai & Yan Jia. (2021) Determination of carboxylesterase 2 by fluorescence probe to guide pancreatic adenocarcinoma profiling. Chemical Physics Letters 785, pages 139143.
Crossref
Crossref
Hideaki Mamada, Kazuhiko Iwamoto, Yukihiro Nomura & Yoshihiro Uesawa. (2021) Predicting blood-to-plasma concentration ratios of drugs from chemical structures and volumes of distribution in humans. Molecular Diversity 25:3, pages 1261-1270.
Crossref
Crossref
Xiaofeng Wu, Rui Wang, Sujie Qi, Nahyun Kwon, Jingjing Han, Heejeong Kim, Haidong Li, Fabiao Yu & Juyoung Yoon. (2021) Rational Design of a Highly Selective Near‐Infrared Two‐Photon Fluorogenic Probe for Imaging Orthotopic Hepatocellular Carcinoma Chemotherapy. Angewandte Chemie International Edition 60:28, pages 15418-15425.
Crossref
Crossref
Xiaofeng Wu, Rui Wang, Sujie Qi, Nahyun Kwon, Jingjing Han, Heejeong Kim, Haidong Li, Fabiao Yu & Juyoung Yoon. (2021) Rational Design of a Highly Selective Near‐Infrared Two‐Photon Fluorogenic Probe for Imaging Orthotopic Hepatocellular Carcinoma Chemotherapy. Angewandte Chemie 133:28, pages 15546-15553.
Crossref
Crossref
Anthony A. Stephenson, Sheng Cao, David J. Taggart, Vinod P. Vyavahare & Zucai Suo. (2021) Design, synthesis, and evaluation of liver-specific gemcitabine prodrugs for potential treatment of hepatitis C virus infection and hepatocellular carcinoma. European Journal of Medicinal Chemistry 213, pages 113135.
Crossref
Crossref
Nigel J. Waters, R. Scott Obach & Li Di. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
113
145
.
Jun Zhang, Dandan Wang, Liwei Zou, Min Xiao, Yufeng Zhang, Ziwei Li, Ling Yang, Guangbo Ge & Zhong Zuo. (2020) Rapid bioluminescence assay for monitoring rat CES1 activity and its alteration by traditional Chinese medicines. Journal of Pharmaceutical Analysis 10:3, pages 253-262.
Crossref
Crossref
Zbigniew P. Kortylewicz, Donald W. Coulter, Guang Han & Janina Baranowska-Kortylewicz. (2019) Norepinephrine-Transporter-Targeted and DNA-Co-Targeted Theranostic Guanidines. Journal of Medicinal Chemistry 63:5, pages 2051-2073.
Crossref
Crossref
Zhao-ming Liu, Hui-jie Du, Ting-qiang Wang, Yan-nan Ma, Jun-ru Liu, Mao-cai Yan & Hui-yun Wang. (2019) Selective and sensitive detection and quantification of human carboxylesterase 1 by a ratiometric fluorescence probe. Dyes and Pigments 171, pages 107711.
Crossref
Crossref
Sulagna MukherjeeMinji ChoiJong Won Yun. (2019) Novel regulatory roles of carboxylesterase 3 in lipid metabolism and browning in 3T3-L1 white adipocytes. Applied Physiology, Nutrition, and Metabolism 44:10, pages 1089-1098.
Crossref
Crossref
Amit Sharma, Eun-Joong Kim, Seokgyu Mun, Myung Sun Ji, Bong Geun Chung & Jong Seung Kim. (2019) Molecular theranostic based on esterase-mediated drug activation for hepatocellular carcinoma. Dyes and Pigments 163, pages 628-633.
Crossref
Crossref
Yihan Wu, Di Wang, Xiaoqin Yang, Chaomei Fu, Liang Zou & Jinming Zhang. (2019) Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice. Biomedicine & Pharmacotherapy 109, pages 2252-2261.
Crossref
Crossref
Amit Sharma, Min-Goo Lee, Hu Shi, Miae Won, Jonathan F. Arambula, Jonathan L. Sessler, Jin Yong Lee, Sung-Gil Chi & Jong Seung Kim. (2018) Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug. Chem 4:10, pages 2370-2383.
Crossref
Crossref
Oscar B. Torres, Alexander J. Duval, Agnieszka Sulima, Joshua F. G. Antoline, Arthur E. Jacobson, Kenner C. Rice, Carl R. Alving & Gary R. Matyas. (2018) A rapid solution-based method for determining the affinity of heroin hapten-induced antibodies to heroin, its metabolites, and other opioids. Analytical and Bioanalytical Chemistry 410:16, pages 3885-3903.
Crossref
Crossref
Zhengqi Ye & Hong Gao. (2018) Approaches to measure protein binding of enzymatically unstable compounds in plasma. Bioanalysis 10:7, pages 451-459.
Crossref
Crossref
An-Hua Wang, Xiang-Ge Tian, Yong-Lei Cui, Xiao-Kui Huo, Bao-Jing Zhang, Sa Deng, Lei Feng, Xiao-Chi Ma, Jing-Ming Jia & Chao Wang. (2018) Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2. Phytochemistry 146, pages 82-90.
Crossref
Crossref
Yu-Zhuo Wu, Hua-Wei Zhang, Zhao-Hui Sun, Jun-Gui Dai, You-Cai Hu, Rui Li, Peng-Cheng Lin, Gui-Yang Xia, Ling-Yan Wang, Bo-Lin Qiu, Jing-Fang Zhang, Guang-Bo Ge & Sheng Lin. (2018) Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities. European Journal of Medicinal Chemistry 145, pages 717-725.
Crossref
Crossref
Paul Hermant, Damien Bosc, Catherine Piveteau, Ronan Gealageas, BaoVy Lam, Cyril Ronco, Matthieu Roignant, Hasina Tolojanahary, Ludovic Jean, Pierre-Yves Renard, Mohamed Lemdani, Marilyne Bourotte, Adrien Herledan, Corentin Bedart, Alexandre Biela, Florence Leroux, Benoit Deprez & Rebecca Deprez-Poulain. (2017) Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox. Journal of Medicinal Chemistry 60:21, pages 9067-9089.
Crossref
Crossref
An-Hua Wang, Xiao-Kui Huo, Lei Feng, Cheng-Peng Sun, Sa Deng, Hou-Li Zhang, Bao-Jing Zhang, Xiao-Chi Ma, Jing-Ming Jia & Chao Wang. (2017) Phenolic glycosides and monoterpenoids from the roots of Euphorbia ebracteolata and their bioactivities. Fitoterapia 121, pages 175-182.
Crossref
Crossref
Chao Wang, Xiao-Kui Huo, Bao-Jing Zhang, Cheng-Peng Sun, Xiang-Ge Tian, Sa Deng, Bin Li, Wei Wang, Pei-Pei Dong & Xiao-Chi Ma. (2017) Highly regioselective glucosylation of alcoholic hydroxyls of protostane triterpenoids mediated by fungal biotransformation. Catalysis Communications 89, pages 40-43.
Crossref
Crossref
Ya-Jing Liu, Shi-Yang Li, Jie Hou, Yan-Fang Liu, Dan-Dan Wang, Yong-Shan Jiang, Guang-Bo Ge, Xin-Miao Liang & Ling Yang. (2016) Identification and characterization of naturally occurring inhibitors against human carboxylesterase 2 in White Mulberry Root-bark. Fitoterapia 115, pages 57-63.
Crossref
Crossref
Pahweenvaj Ratnatilaka Na Bhuket, Nuansri Niwattisaiwong, Patanachai Limpikirati, Phisit Khemawoot, Pasarapa Towiwat, Boonsri Ongpipattanakul & Pornchai Rojsitthisak. (2016) Simultaneous determination of curcumin diethyl disuccinate and its active metabolite curcumin in rat plasma by LC–MS/MS: Application of esterase inhibitors in the stabilization of an ester-containing prodrug. Journal of Chromatography B 1033-1034, pages 301-310.
Crossref
Crossref
Li-Wei Zou, Yao-Guang Li, Ping Wang, Kun Zhou, Jie Hou, Qiang Jin, Da-Cheng Hao, Guang-Bo Ge & Ling Yang. (2016) Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2. European Journal of Medicinal Chemistry 112, pages 280-288.
Crossref
Crossref
Oscar B. Torres, Joshua F. G. Antoline, Fuying Li, Rashmi Jalah, Arthur E. Jacobson, Kenner C. Rice, Carl R. Alving & Gary R. Matyas. (2015) A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse. Analytical and Bioanalytical Chemistry 408:4, pages 1191-1204.
Crossref
Crossref
Dan-Dan Wang, Qiang Jin, Li-Wei Zou, Jie Hou, Xia Lv, Wei Lei, Hai-Ling Cheng, Guang-Bo Ge & Ling Yang. (2016) A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples. Chemical Communications 52:15, pages 3183-3186.
Crossref
Crossref
Zhen-Peng Mai, Kun Zhou, Guang-Bo Ge, Chao Wang, Xiao-Kui Huo, Pei-Pei Dong, Sa Deng, Bao-Jing Zhang, Hou-Li Zhang, Shan-Shan Huang & Xiao-Chi Ma. (2015)
Protostane Triterpenoids from the Rhizome of
Alisma orientale
Exhibit Inhibitory Effects on Human Carboxylesterase 2
. Journal of Natural Products 78:10, pages 2372-2380.
Crossref
Crossref
Yao-Guang Li, Jie Hou, Shi-Yang Li, Xia Lv, Jing Ning, Ping Wang, Zhao-Ming Liu, Guang-Bo Ge, Jia-Yan Ren & Ling Yang. (2015) Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia 101, pages 99-106.
Crossref
Crossref
Hugues Chanteux, Maria Rosa, Claude Delatour, Chandra Prakash, Steven Smith & Jean-Marie Nicolas. (2014)
In Vitro Hydrolysis and Transesterification of CDP323, an
α
4
β
1/
α
4
β
7 Integrin Antagonist Ester Prodrug
. Drug Metabolism and Disposition 42:1, pages 153-161.
Crossref
Crossref
Lei Feng, Zhao-Ming Liu, Liang Xu, Xia Lv, Jing Ning, Jie Hou, Guang-Bo Ge, Jing-Nan Cui & Ling Yang. (2014) A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications. Chem. Commun. 50:93, pages 14519-14522.
Crossref
Crossref
Nigel J. Waters, R. Scott Obach & Li Di. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
119
145
.
Lars B Nilsson. (2013) The bioanalytical challenge of determining unbound concentration and protein binding for drugs. Bioanalysis 5:24, pages 3033-3050.
Crossref
Crossref
Junjie Zhu, Mengmeng Ning, Cen Guo, Lina Zhang, Guoyu Pan, Ying Leng & Jianhua Shen. (2013) Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold. European Journal of Medicinal Chemistry 69, pages 55-68.
Crossref
Crossref
Xiaolei Wang, Jesung Moon, Michael E. Dodge, Xinchao Pan, Lishu Zhang, Jordan M. Hanson, Rubina Tuladhar, Zhiqiang Ma, Heping Shi, Noelle S. Williams, James F. Amatruda, Thomas J. Carroll, Lawrence Lum & Chuo Chen. (2013) The Development of Highly Potent Inhibitors for Porcupine. Journal of Medicinal Chemistry 56:6, pages 2700-2704.
Crossref
Crossref
E. V. Rudakova, G. F. Makhaeva, T. G. Galenko, A. Yu. Aksinenko, V. B. Sokolov & I. V. Martynov. (2013) A new selective inhibitor of mouse blood plasma carboxylesterase. Doklady Biochemistry and Biophysics 449:1, pages 87-89.
Crossref
Crossref
Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu & Zhiyang Zhao. (2013) Impact of Hydrolysis-Mediated Clearance on the Pharmacokinetics of Novel Anaplastic Lymphoma Kinase Inhibitors. Drug Metabolism and Disposition 41:1, pages 238-247.
Crossref
Crossref
Antonia F. Stepan, Vincent Mascitti, Kevin Beaumont & Amit S. Kalgutkar. (2013) Metabolism-guided drug design. MedChemComm 4:4, pages 631.
Crossref
Crossref
Chengliang Zhang, Ping Gao, Weifeng Yin, Yanjiao Xu, Daochun Xiang & Dong Liu. (2012) Dexamethasone regulates differential expression of carboxylesterase 1 and carboxylesterase 2 through activation of nuclear receptors. Journal of Huazhong University of Science and Technology [Medical Sciences] 32:6, pages 798-805.
Crossref
Crossref
Yuichiro Sato, Aiji Miyashita, Takafumi Iwatsubo & Takashi Usui. (2012) Conclusive Identification of the Oxybutynin-Hydrolyzing Enzyme in Human Liver. Drug Metabolism and Disposition 40:5, pages 902-906.
Crossref
Crossref
. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design
111
158
.
Lichuan Liu, Jason S. Halladay, Young Shin, Susan Wong, Melis Coraggio, Hank La, Matthew Baumgardner, Hoa Le, Sashi Gopaul, Jason Boggs, Peter Kuebler, John C. DavisJr.Jr., X. Charlene Liao, Joseph W. Lubach, Alan Deese, C. Gregory Sowell, Kevin S. Currie, Wendy B. Young, S. Cyrus Khojasteh, Cornelis E. C. A. Hop & Harvey Wong. (2011) Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor. Drug Metabolism and Disposition 39:10, pages 1840-1849.
Crossref
Crossref
Q. Sun, T. W. Harper, E. A. Dierks, L. Zhang, S. Chang, A. D. Rodrigues & P. Marathe. (2011)
1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of
N
-Acetyltransferase
. Drug Metabolism and Disposition 39:9, pages 1674-1679.
Crossref
Crossref
Joana Lamego, Ana Sofia Coroadinha & Ana Luísa Simplício. (2011) Detection and Quantification of Carboxylesterase 2 Activity by Capillary Electrophoresis. Analytical Chemistry 83:3, pages 881-887.
Crossref
Crossref