Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

H. EngPharmacokinetics, Dynamics and Metabolism, Groton, CT, USA

M. NiosiPharmacokinetics, Dynamics and Metabolism, Groton, CT, USA

T. S. McDonaldPharmacokinetics, Dynamics and Metabolism, Groton, CT, USA

A. WolfordPharmacokinetics, Dynamics and Metabolism, Groton, CT, USA

Y. ChenPharmacokinetics, Dynamics and Metabolism, Groton, CT, USA

S. T. M. SimilaMedicinal Chemistry, Pfizer Global Research and Development, Groton, CT, USA

J. N. BaumanPharmacokinetics, Dynamics and Metabolism, Groton, CT, USA

J. WarmusMedicinal Chemistry, Pfizer Global Research and Development, Groton, CT, USA

A. S. KalgutkarPharmacokinetics, Dynamics and Metabolism, Groton, CT, USACorrespondence[email protected]

Your download is now in progress and you may close this window