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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 6
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Animal Pharmacokinetics and Metabolism

Metabolism, pharmacokinetics and excretion of the GABAA receptor partial agonist [14C]CP-409,092 in rats

A. KamelDepartment of Pharmacokinetics, Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer, Inc, Groton, CT, USACorrespondence[email protected]
,
R. S. ObachDepartment of Pharmacokinetics, Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer, Inc, Groton, CT, USA
,
E. TsengDepartment of Pharmacokinetics, Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer, Inc, Groton, CT, USA
&
A. SawantDepartment of Pharmacokinetics, Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer, Inc, Groton, CT, USA
Pages 400-414 | Received 19 Dec 2009, Accepted 17 Feb 2010, Published online: 24 Mar 2010

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Roberto Mandrioli & Laura Mercolini. (2015) Discontinued anxiolytic drugs (2009 – 2014). Expert Opinion on Investigational Drugs 24:4, pages 557-573.
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Aarti Sawant Basak, Wonkyung Byon, Elaine Tseng-Lovering, Carrie Funk, Linda Wood, Chang Lin, Marielle Delnomdedieu, Patrick Verhoest, Vinod Parikh, Loretta M. Cox, Emily Miller, Hongying Gao & Ronald S. Obach. (2014) Metabolism and clinical pharmacokinetics of 2-methyl-n-(2′-(pyrrolidinyl-1-ylsulfonyl)-n-[1,1′-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools. Xenobiotica 44:5, pages 438-454.
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Amin Kamel, Kevin Colizza, Mithat Gunduz, Shawn Harriman & R. Scott Obach. (2012) In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase. Xenobiotica 42:4, pages 355-362.
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A.D. Sawant, E.L. Miller, D.B. Duignan, J. Brodfuehrer, S.M. Winter, F.R. Nelson, A. Kamel, R.S. Obach & A.D.N. Vaz. (2010) Understanding the clinical pharmacokinetics of a GABAA partial agonist by application of in vitro tools. Xenobiotica 40:7, pages 476-484.
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April Bai, Veerabahu Shanmugasundaram, Julie V. Selkirk, Sekhar Surapaneni & Deepak Dalvie. (2021) Investigation into MAO B–Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of ( S )-Enantiomer of Indaneamine (RP101075) by MAO B . Drug Metabolism and Disposition 49:8, pages 601-609.
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Tomas Horsten & Wim Dehaen. (2021) 4,5,6,7-Tetrahydroindol-4-Ones as a Valuable Starting Point for the Synthesis of Polyheterocyclic Structures. Molecules 26:15, pages 4596.
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. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design 111 158 .

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