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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 12
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General Xenobiochemistry

Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin

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Pages 807-816 | Received 08 Jul 2010, Accepted 27 Aug 2010, Published online: 23 Sep 2010

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Hui-dan Zhu, Ni Gu, Meng Wang, Hong-ru Kong & Meng-tao Zhou. (2015) Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4. Drug Development and Industrial Pharmacy 41:11, pages 1824-1828.
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Fen Chen, Xuejia Zhai, Chaoran Zhu & Yongning Lu. (2015) Effects of capsaicin on pharmacokinetics of pitavastatin in rats. Xenobiotica 45:2, pages 171-176.
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R.-D. Treede, T. Wagner, K.-U. Kern, I.W. Husstedt, G. Arendt, F. Birklein, T. Cegla, R. Freynhagen, H.-H. Gockel, M.-L. Heskamp, H. Jager, R. Joppich, C. Maier, A. Leffler, H.-H. Nagelein, R. Rolke, S. Seddigh, C. Sommer, S. Stander, G. Wasner & R. Baron. (2013) Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. Current Medical Research and Opinion 29:5, pages 527-538.
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Shin Takusagawa, Aiji Miyashita, Takafumi Iwatsubo & Takashi Usui. (2012) In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist. Xenobiotica 42:12, pages 1187-1196.
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Xue-jia Zhai & Yong-ning Lu. (2012) Food–drug interactions: effect of capsaicin on the pharmacokinetics of galantamine in rats. Xenobiotica 42:11, pages 1151-1155.
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Qing-Hao Zhang, Jin-Ping Hu, Bao-Lian Wang & Yan Li. (2012) Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo . Journal of Asian Natural Products Research 14:4, pages 382-395.
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Articles from other publishers (27)

Janayne L. Silva, Elandia A. Santos & Jacqueline I. Alvarez-Leite. (2023) Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?. Nutrients 15:20, pages 4469.
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Adam Yasgar, Danielle Bougie, Richard T. Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K. Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V. Zakharov & Anton Simeonov. (2023) Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS Pharmacology & Translational Science 6:5, pages 683-701.
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Marco Kreidl, Matthias Rainer, Günther K. Bonn & Herbert Oberacher. (2021) Electrochemical Simulation of the Oxidative Capsaicin Metabolism. Chemical Research in Toxicology 34:12, pages 2522-2533.
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Vipin Arora, James N. Campbell & Man-Kyo Chung. (2021) Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain. Pharmacology & Therapeutics 220, pages 107743.
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O. Morgan Hall, Alaina Broussard, Tierra Range, Michelle A. Carroll Turpin, Savannah Ellis, Victoria M. Lim, Elyse M. Cornett & Alan David Kaye. (2020) Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations. Current Pain and Headache Reports 24:9.
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Xuejia Zhai, Yiming Feng, Jun Liu, Jie Li, Yan Zong, Zhan Tuo, Shenrong Gao & Yi Lv. (2019) Pharmacokinetic effects of capsaicin on vinblastine in rats mediated by CYP3A and Mrp2. Fundamental & Clinical Pharmacology 33:4, pages 376-384.
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Anna Wasik, Anna Krupa & Marcin Siwek. (2019) Interactions of antidepressants, mood-stabilisers and antipsychotics with food. Pharmacotherapy in Psychiatry and Neurology 35:1, pages 51-74.
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Brunno Felipe Ramos Caetano, Mariana Baptista Tablas, Natália Elias Ferreira Pereira, Nelci Antunes de Moura, Robson Francisco Carvalho, Maria Aparecida Marchesan Rodrigues & Luis Fernando Barbisan. (2018) Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats. Toxicology and Applied Pharmacology 338, pages 93-102.
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Nanxi Wang, Chaoran Zhu, Xinlin Zhang, Xuejia Zhai & Yongning Lu. (2018) Food–drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat. Journal of Functional Foods 40, pages 292-298.
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Seok-Cheol Cho, Hyosung Lee & Bu Young Choi. (2017) An updated review on molecular mechanisms underlying the anticancer effects of capsaicin. Food Science and Biotechnology 26:1, pages 1-13.
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Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan & Lee Yong Lim. (2017) Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities. Drug Metabolism and Disposition 45:1, pages 49-55.
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Yong-Hwan Shin, Jin Kim & Kyungpyo Park. (2016) The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules 21:7, pages 835.
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Ya Zhang, Zhimin Huang, E. Omari-Siaw, Shuang Lu, Yuan Zhu, Dongmei Jiang, Miaomiao Wang, Jiangnan Yu, Ximing Xu & Weiming Zhang. (2015) Preparation and In Vitro–In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability. AAPS PharmSciTech 17:2, pages 339-349.
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Guolin Shen, Cheng Wang, Lili Zhou, Lei Li, Huiming Chen, Wenlian Yu & Haishan Li. (2015) CYP450 Enzyme-Mediated Metabolism of TCAS and Its Inhibitory and Induced Effects on Metabolized Enzymes in Vitro. International Journal of Environmental Research and Public Health 12:9, pages 10783-10793.
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Sixun Guo, Yan Liu, Zhiping Lin, Sheng Tai, Shuo Yin & Gaofeng Liu. (2014) Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes. BMC Complementary and Alternative Medicine 14:1.
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William D. Rollyson, Cody A. Stover, Kathleen C. Brown, Haley E. Perry, Cathryn D. Stevenson, Christopher A. McNees, John G. Ball, Monica A. Valentovic & Piyali Dasgupta. (2014) Bioavailability of capsaicin and its implications for drug delivery. Journal of Controlled Release 196, pages 96-105.
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Inés Díaz-Laviada & Nieves Rodríguez-Henche. 2014. Capsaicin as a Therapeutic Molecule. Capsaicin as a Therapeutic Molecule 181 208 .
Xue-jia Zhai, Fang Shi, Fen Chen & Yong-ning Lu. (2013) Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: Involvement of P-glycoprotein and CYP 3A inhibition. Food and Chemical Toxicology 62, pages 323-328.
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Haejin Bae, Guddadarangavvanahally K. Jayaprakasha, Kevin Crosby, John L Jifon & Bhimanagouda S. Patil. (2013) Simultaneous Quantification of Capsaicinoids and Ascorbic Acid from Pungent Peppers. Journal of Chromatographic Science 51:5, pages 412-418.
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Xue-jia Zhai, Jian-guo Chen, Jin-mei Liu, Fang Shi & Yong-ning Lu. (2013) Food–drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Food and Chemical Toxicology 53, pages 168-173.
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Christopher A. Reilly, Fred Henion, Tim S. Bugni, Manivannan Ethirajan, Chris Stockmann, Kartick C. Pramanik, Sanjay K. Srivastava & Garold S. Yost. (2012) Reactive Intermediates Produced from the Metabolism of the Vanilloid Ring of Capsaicinoids by P450 Enzymes. Chemical Research in Toxicology 26:1, pages 55-66.
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Christopher A. Reilly. 2013. Role of Capsaicin in Oxidative Stress and Cancer. Role of Capsaicin in Oxidative Stress and Cancer 107 129 .
Peijian Wang, Zhencheng Yan, Jian Zhong, Jing Chen, Yinxing Ni, Li Li, Liqun Ma, Zhigang Zhao, Daoyan Liu & Zhiming Zhu. (2012) Transient Receptor Potential Vanilloid 1 Activation Enhances Gut Glucagon-Like Peptide-1 Secretion and Improves Glucose Homeostasis. Diabetes 61:8, pages 2155-2165.
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Keith Bley, Gary Boorman, Bashir Mohammad, Donald McKenzie & Sunita Babbar. (2012) A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin. Toxicologic Pathology 40:6, pages 847-873.
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Eun Hee Han, Hyung Gyun Kim, Jae Ho Choi, Yin‐Jin Jang, Sang Seop Lee, Kwang‐il Kwon, Eunyoung Kim, Kyeumhan Noh, Tae Cheon Jeong, Yong Pil Hwang, Young Chul Chung, Wonku Kang & Hye Gwang Jeong. (2012) Capsaicin induces CYP 3 A 4 expression via pregnane X receptor and CCAAT /enhancer‐binding protein β activation . Molecular Nutrition & Food Research 56:5, pages 797-809.
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H. Bai, H. Li, W. Zhang, K. A. Matkowskyj, J. Liao, S. K. Srivastava & G.-Y. Yang. (2011) Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice. Carcinogenesis 32:11, pages 1689-1696.
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Naomi Toyoda-Hokaiwado, Yumiko Yasui, Makiko Takamune, Masami Yamada, Mina Muramatsu, Kenichi Masumura, Toshihiro Ohta, Takuji Tanaka & Takehiko Nohmi. (2011) Modulatory Effects of Capsaicin on N-diethylnitrosamine (DEN)-induced Mutagenesis in Salmonella typhimurium YG7108 and DEN-induced Hepatocarcinogenesis in gpt Delta Transgenic Rats. Genes and Environment 33:4, pages 160-166.
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