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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 12
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General Xenobiochemistry

In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4

Jinghu LiDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
Tanja GödeckeDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
Shao-Nong ChenDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
Ayano ImaiDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
David C. LankinDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
Norman R. FarnsworthDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
Guido F. PauliDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
,
Richard B. van BreemenDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USA
&
Dejan NikolićDepartment of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, Illinois, USACorrespondence[email protected]
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Pages 1021-1030 | Received 22 Apr 2011, Accepted 04 Jul 2011, Published online: 09 Aug 2011

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Chunhuan Jin, Xin He, Fangliang Zhang, Lina He, Junxiu Chen, Lili Wang, Lijun An & Yaowen Fan. (2015) Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4. Xenobiotica 45:7, pages 571-577.
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Sradhanjali Mohapatra, Ashif Iqubal, Mohammad Javed Ansari, Bisma Jan, Sultan Zahiruddin, Mohd Aamir Mirza, Sayeed Ahmad & Zeenat Iqbal. (2022) Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An Up-Close and In-Depth Review. Pharmaceuticals 15:3, pages 278.
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Rafaele de A. Rodrigues, Aline de S. Ramos, José Luiz P. Ferreira, Jefferson Rocha de A. Silva, Ana Clara B. Maria, Maíra Martins H. de Almeida & Ana Claudia F. Amaral. (2022) Highlights on Important Medicinal Plants for the Menopause Syndrome. Current Women s Health Reviews 18:1.
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Hua-Li Zuo, Hsi-Yuan Huang, Yang-Chi-Dung Lin, Xiao-Xuan Cai, Xiang-Jun Kong, Dai-Lin Luo, Yu-Heng Zhou & Hsien-Da Huang. (2022) Enzyme Activity of Natural Products on Cytochrome P450. Molecules 27:2, pages 515.
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Charleen G. Don & Martin Smieško. (2020) In Silico Pharmacogenetics CYP2D6 Study Focused on the Pharmacovigilance of Herbal Antidepressants. Frontiers in Pharmacology 11.
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Da-Cheng Hao. 2019. Ranunculales Medicinal Plants. Ranunculales Medicinal Plants 125 173 .
Linda Saxe Einbond, Morando Soffritti, Davide Degli Esposti, Hsan-au Wu, Michael Balick, Hongbao Ma, Stephen Redenti & Alan Roter. (2018) A transcriptomic analysis of black cohosh: Actein alters cholesterol biosynthesis pathways and synergizes with simvastatin. Food and Chemical Toxicology 120, pages 356-366.
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Lin-Hu Ye, Xin-Qian Zhao, Ling-Ti Kong, Li-Sha Wang, Xue Tao, Hui Wu, Mei He & Qi Chang. (2018) Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro . Biomedical Chromatography 32:8, pages e4250.
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Serhat Sezai Çiçek, Ulrich Girreser & Christian Zidorn. (2018) Quantification of the total amount of black cohosh cycloartanoids by integration of one specific 1 H NMR signal. Journal of Pharmaceutical and Biomedical Analysis 155, pages 109-115.
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K. Simon Yeung, Marisol Hernandez, Jun J. Mao, Ingrid Haviland & Jyothirmai Gubili. (2018) Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho‐oncologic relevance . Phytotherapy Research 32:5, pages 865-891.
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Lin-hu Ye, Ling-ti Kong, Bing-xin Xiao, Qian Wang, Xiao-xi He, Xin-min Liu & Qi Chang. (2017) Screening of Eleven Commonly Used Traditional Chinese Medicines for Inhibitory Effects on Human Cytochrome P450 Enzymes. Chinese Herbal Medicines 9:2, pages 169-175.
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Lin-Hu Ye, Ling-Ti Kong, Ming-Zhu Yan, Fang-Rui Cao, Li-Sha Wang, Yong-Hong Liao, Rui-Le Pan & Qi Chang. (2016) Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity. Journal of Ethnopharmacology 194, pages 913-917.
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A. A. Sprouse & R. B. van Breemen. (2015) Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements. Drug Metabolism and Disposition 44:2, pages 162-171.
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Juergen Drewe, Kathleen A Bucher & Catherine Zahner. (2015) A systematic review of non-hormonal treatments of vasomotor symptoms in climacteric and cancer patients. SpringerPlus 4:1.
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Richard B. van Breemen. (2015) Development of Safe and Effective Botanical Dietary Supplements. Journal of Medicinal Chemistry 58:21, pages 8360-8372.
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Denisa Margină, Mihaela Ilie, Daniela Grădinaru, Vasilis P. Androutsopoulos, Demetrios Kouretas & Aristidis M. Tsatsakis. (2015) Natural products—friends or foes?. Toxicology Letters 236:3, pages 154-167.
Crossref
Da Cheng Hao, Xiao-Jie Gu & Pei Gen Xiao. 2015. Medicinal Plants. Medicinal Plants 293 340 .
Dejan Nikolić, David C. Lankin, Tamara Cisowska, Shao-Nong Chen, Guido F. Pauli & Richard B. van Breemen. 2015. The Formation, Structure and Activity of Phytochemicals. The Formation, Structure and Activity of Phytochemicals 31 75 .
Lin-Hu Ye, Xiao-Xi He, Ling-Ti Kong, Yong-Hong Liao, Rui-Le Pan, Bing-Xin Xiao, Xin-Min Liu & Qi Chang. (2014) Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. Journal of Ethnopharmacology 153:1, pages 190-196.
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Gregory S Gorman, Lori Coward, Adrienne Darby & Bethany Rasberry. (2013) Effects of herbal supplements on the bioactivation of chemotherapeutic agents. Journal of Pharmacy and Pharmacology 65:7, pages 1014-1025.
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Sylvain L’Espérance, Suzanne Frenette, Anne Dionne & Jean-Yves Dionne. (2013) Pharmacological and non-hormonal treatment of hot flashes in breast cancer survivors: CEPO review and recommendations. Supportive Care in Cancer 21:5, pages 1461-1474.
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Dejan Nikolić, Tanja Gödecke, Shao-Nong Chen, Jerry White, David C. Lankin, Guido F. Pauli & Richard B. van Breemen. (2012) Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia 83:3, pages 441-460.
Crossref
Lay Kek Teh & Leif Bertilsson. (2012) Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance. Drug Metabolism and Pharmacokinetics 27:1, pages 55-67.
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