Xenobiotica, Volume 41, Issue 12 (2011)

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Xenobiotica, Volume 41, Issue 12 (2011)

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General Xenobiochemistry

Article
In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4
Jinghu Li, Tanja Gödecke, Shao-Nong Chen, Ayano Imai, David C. Lankin, Norman R. Farnsworth, Guido F. Pauli, Richard B. van Breemen & Dejan Nikolić
Pages: 1021-1030
Published online: 09 Aug 2011
AbstractforIn vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4 | Full Text | References | PDF (897.5 KB) | Supplemental
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Article
Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126
Bingxuan Wang, Larry W. Robertson, Kai Wang & Gabriele Ludewig
Pages: 1031-1043
Published online: 04 Oct 2011
AbstractforSpecies difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126 | Full Text | References | PDF (1 MB)
  • 238 Views
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Article
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells
Barbara Fedejko-Kap, Magdalena Niemira, Anna Radominska-Pandya & Zofia Mazerska
Pages: 1044-1055
Published online: 23 Aug 2011
AbstractforFlavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells | Full Text | References | PDF (865.1 KB)
  • 349 Views
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Article
Determination of cytochrome P450 enzymes involved in the metabolism of (−)-terpinen-4-ol by human liver microsomes
M. Miyazawa & R. Haigou
Pages: 1056-1062
Published online: 05 Nov 2011
AbstractforDetermination of cytochrome P450 enzymes involved in the metabolism of (−)-terpinen-4-ol by human liver microsomes | Full Text | References | PDF (794.8 KB)
  • 276 Views
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Clinical Pharmacokinetics and Metabolism

Article
Disposition, metabolism and mass balance of [14C]apremilast following oral administration
Matthew Hoffmann, Gondi Kumar, Peter Schafer, Dorota Cedzik, Lori Capone, Kei-Lai Fong, Zheming Gu, Dennis Heller, Hao Feng, Sekhar Surapaneni, Oscar Laskin & Anfan Wu
Pages: 1063-1075
Published online: 23 Aug 2011
AbstractforDisposition, metabolism and mass balance of [14C]apremilast following oral administration | Full Text | References | PDF (1 MB)
  • 3494 Views
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process
Edna F Choo, Bruno Alicke, Jason Boggs, Vikki Dinkel, Stephen Gould, Jonas Grina, Kristina West, Kapil Menghrajani, Yingqing Ran, Joachim Rudolph & Steve Wenglowsky
Pages: 1076-1087
Published online: 25 Aug 2011
AbstractforPreclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process | Full Text | References | PDF (960.4 KB)
  • 419 Views
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Article
Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human
Laurent Salphati, Jodie Pang, Emile G. Plise, Bilin Chou, Jason S. Halladay, Alan G. Olivero, Patrick J. Rudewicz, Qingping Tian, Susan Wong & Xiaolin Zhang
Pages: 1088-1099
Published online: 13 Aug 2011
AbstractforPreclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human | Full Text | References | PDF (970.4 KB)
  • 764 Views
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Article
Pharmacokinetics of lurasidone, a novel atypical anti-psychotic drug, in rats
Kyeong-Ryoon Lee, Yoon-Jee Chae & Tae-Sung Koo
Pages: 1100-1107
Published online: 13 Aug 2011
AbstractforPharmacokinetics of lurasidone, a novel atypical anti-psychotic drug, in rats | Full Text | References | PDF (669.4 KB)
  • 696 Views
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Molecular Toxicology

Article
The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structure
Minxia M. He, Tao Ji, Robert J. Barbuch, Kristina Campanale, Ron Lantz, Chad Hadden & August Wilke
Pages: 1108-1121
Published online: 05 Sep 2011
AbstractforThe fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structure | Full Text | References | PDF (1.1 MB)
  • 156 Views
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Pharmacogenetics

Article
Polymorphism in glutathione S-transferases: Susceptibility and treatment outcome for head and neck cancer
Munindra Ruwali, Madhu Singh, Mohan C. Pant & Devendra Parmar
Pages: 1122-1130
Published online: 29 Sep 2011
AbstractforPolymorphism in glutathione S-transferases: Susceptibility and treatment outcome for head and neck cancer | Full Text | References | PDF (662.8 KB)
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Acknowledgements

Acknowledgements
Pages: 1131-1132
Published online: 05 Nov 2011
CitationforAcknowledgements | Full Text | PDF (489.5 KB)
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