Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals

Hiroshi MaedaCorrespondence[email protected]

Hiroshi KodairaPharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan

Kazuhiro FujitaPharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan

Hiroyuki KobayashiPharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan

Junko UshikiPharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan

Takeo NakanishiDepartment of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Ikumi TamaiDepartment of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals

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Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals

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