Xenobiotica, Volume 42, Issue 7 (2012)

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Xenobiotica, Volume 42, Issue 7 (2012)

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General Xenobiochemistry

Article
Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
Eun-Young Kwak, Won-Sik Shim, Ji-Eun Chang, Saeho Chong, Dae-Duk Kim, Suk-Jae Chung & Chang-Koo Shim
Pages: 603-613
Published online: 10 Jan 2012
AbstractforEnhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters | Full Text | References | PDF (807.8 KB)
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Article
Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene
Takeshi Hori, Liangjing Jin, Ayako Fujii, Tomomi Furihata, Yuko Nagahara, Kan Chiba & Masakiyo Hosokawa
Pages: 614-623
Published online: 11 Jan 2012
AbstractforDexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene | Full Text | References | PDF (1 MB)
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Article
Similarities in diesel exhaust particles induced alterations in expression of cytochrome P-450 and glutathione S-transferases in rat lymphocytes and lungs
Ankita Srivastava, Sanjay Yadav, Amit Sharma, UN Dwivedi, SJS Flora & Devendra Parmar
Pages: 624-632
Published online: 21 Feb 2012
AbstractforSimilarities in diesel exhaust particles induced alterations in expression of cytochrome P-450 and glutathione S-transferases in rat lymphocytes and lungs | Full Text | References | PDF (739.9 KB)
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Article
Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4
Masato Ohbuchi, Kiyoshi Noguchi, Akio Kawamura & Takashi Usui
Pages: 633-640
Published online: 07 Feb 2012
AbstractforDifferent effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4 | Full Text | References | PDF (681.5 KB) | Supplemental
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Article
Effects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats
Theerada Taesotikul, Miki Nakajima, Wichittra Tassaneeyakul & Tsuyoshi Yokoi
Pages: 641-648
Published online: 20 Feb 2012
AbstractforEffects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats | Full Text | References | PDF (729.5 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals
Hiroshi Maeda, Hiroshi Kodaira, Kazuhiro Fujita, Hiroyuki Kobayashi, Junko Ushiki, Takeo Nakanishi & Ikumi Tamai
Pages: 649-659
Published online: 10 Feb 2012
AbstractforSpecies differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals | Full Text | References | PDF (1,023.5 KB)
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Animal Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats
Kathryn W. Woodburn, Christopher P. Holmes, Susan D. Wilson, Kei-Lai Fong, Randall J. Press, Yuu Moriya & Yoshihiko Tagawa
Pages: 660-670
Published online: 22 Dec 2011
AbstractforAbsorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats | Full Text | References | PDF (800.7 KB)
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Open Access
Article
The utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P1 agonists
Simon Taylor, James R. J. Gray, Robert Willis, Nigel Deeks, Andrea Haynes, Colin Campbell, Pam Gaskin, Karen Leavens, Emmanuel Demont, Simon Dowell, Jenni Cryan, Mary Morse, Aarti Patel, Helen Garden & Jason Witherington
Pages: 671-686
Published online: 09 Jan 2012
AbstractforThe utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P1 agonists | Full Text | References | PDF (1 MB)
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Article
Metabolism and excretion of TH-302 in dogs
Donald Jung, Hailong Jiao, Jian-Xi Duan, Mark Matteucci & Ronghua Wang
Pages: 687-700
Published online: 21 Feb 2012
AbstractforMetabolism and excretion of TH-302 in dogs | Full Text | References | PDF (2.4 MB)
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Article
Pre-clinical pharmacokinetics of the acridine antitumour candidate AC04 and its 1-oxo-metabolite plasma profile
Maiara Cássia Pigatto, Flávia De Toni Uchôa, Bruna Torres, Sandra Haas, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Norberto Peporine Lopes & Teresa Dalla Costa
Pages: 701-707
Published online: 07 Feb 2012
AbstractforPre-clinical pharmacokinetics of the acridine antitumour candidate AC04 and its 1-oxo-metabolite plasma profile | Full Text | References | PDF (698.3 KB)
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