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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 9
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General Xenobiochemistry

Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier

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Pages 880-890 | Received 07 Feb 2012, Accepted 09 Mar 2012, Published online: 18 Apr 2012

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Read on this site (4)

Peer Tfelt-Hansen. (2021) Pharmacological strategies to treat attacks of episodic migraine in adults. Expert Opinion on Pharmacotherapy 22:3, pages 305-316.
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Massoud Saidijam, Fatemeh Karimi Dermani, Sareh Sohrabi & Simon G. Patching. (2018) Efflux proteins at the blood–brain barrier: review and bioinformatics analysis. Xenobiotica 48:5, pages 506-532.
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Daniella Kovacsics, Izabel Patik & Csilla Özvegy-Laczka. (2017) The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions. Expert Opinion on Drug Metabolism & Toxicology 13:4, pages 409-424.
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Tianyu Liu & Qingyong Li. (2014) Organic anion-transporting polypeptides: a novel approach for cancer therapy. Journal of Drug Targeting 22:1, pages 14-22.
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Articles from other publishers (31)

Austin Sun, Bruno Hagenbuch, Edward J. Kelly & Joanne Wang. (2023) Molecular Mechanisms of Organic Anion Transporting Polypeptide–Mediated Organic Anion Clearance at the Blood–Cerebrospinal Fluid Barrier. Molecular Pharmacology 104:6, pages 255-265.
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Md Masud Parvez, Armin Sadighi, Yeseul Ahn, Steve F. Keller & Julius O. Enoru. (2023) Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition. Pharmaceutics 15:10, pages 2473.
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Chandrali S. Bhattacharya, Andrea R. Masters, Christine Bach, Anthony L. Sinn, Melissa A. Trowbridge & Robert E. StratfordJr.Jr.. (2023) Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain. European Journal of Drug Metabolism and Pharmacokinetics 48:2, pages 171-187.
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Anima M. Schäfer, Henriette E. Meyer zu Schwabedissen, Sandra Bien-Möller, Andrea Hubeny, Silke Vogelgesang, Stefan Oswald & Markus Grube. (2020) OATP1A2 and OATP2B1 Are Interacting with Dopamine-Receptor Agonists and Antagonists. Molecular Pharmaceutics 17:6, pages 1987-1995.
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Melissa S. Unger, Jennypher Mudunuru, Matthias Schwab, Carsten Hopf, Gerard Drewes, Anne T. Nies, Maciej J. Zamek-Gliszczynski & Friedrich B. M. Reinhard. (2020) Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space. Molecular Pharmaceutics.
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Hrvoje Brzica, Wazir Abdullahi, Bianca G. Reilly & Patrick T. Ronaldson. (2018) Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats. Fluids and Barriers of the CNS 15:1.
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Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki & Hiroyuki Kusuhara. (2018) Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier. Drug Metabolism and Disposition 46:11, pages 1767-1775.
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Xiaoyan Chu, Mingxiang Liao, Hong Shen, Kenta Yoshida, Arik A. Zur, Vikram Arya, Aleksandra Galetin, Kathleen M. Giacomini, Imad Hanna, Hiroyuki Kusuhara, Yurong Lai, David Rodrigues, Yuichi Sugiyama, Maciej J. Zamek-Gliszczynski & Lei Zhang. (2018) Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium. Clinical Pharmacology & Therapeutics 104:5, pages 836-864.
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Maciej J. Zamek-Gliszczynski, Mitchell E. Taub, Paresh P. Chothe, Xiaoyan Chu, Kathleen M. Giacomini, Richard B. Kim, Adrian S. Ray, Sophie L. Stocker, Jashvant D. Unadkat, Matthias B. Wittwer, Cindy Xia, Sook-Wah Yee, Lei Zhang & Yan Zhang. (2018) Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance. Clinical Pharmacology & Therapeutics 104:5, pages 890-899.
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Anne M. Dolberg & Stephan Reichl. (2018) Expression analysis of human solute carrier (SLC) family transporters in nasal mucosa and RPMI 2650 cells. European Journal of Pharmaceutical Sciences 123, pages 277-294.
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Karissa E. Cottier, Emily A. Galloway, Elisa C. Calabrese, Margaret E. Tome, Erika Liktor-Busa, John Kim, Thomas P. Davis, Todd W. Vanderah & Tally M. Largent-Milnes. (2018) Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery. eneuro 5:4, pages ENEURO.0116-18.2018.
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Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Carlos M. Villalón & Antoinette MaassenVanDenBrink. (2018) Is selective 5-HT 1F receptor agonism an entity apart from that of the triptans in antimigraine therapy?. Pharmacology & Therapeutics 186, pages 88-97.
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Karsten Bartels & Konrad Meissner. (2017) Morphine and the blood-brain barrier: diffusion, uptake, or efflux?La morphine et la barrière hémato-encéphalique : diffusion, absorption / recaptage ou efflux?. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 64:10, pages 997-1001.
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Masahiro Yahata, Koji Chiba, Takao Watanabe & Yuichi Sugiyama. (2017) Possibility of Predicting Serotonin Transporter Occupancy From the In Vitro Inhibition Constant for Serotonin Transporter, the Clinically Relevant Plasma Concentration of Unbound Drugs, and Their Profiles for Substrates of Transporters. Journal of Pharmaceutical Sciences 106:9, pages 2345-2356.
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Jingjing Yu, Zhu Zhou, Jessica Tay-Sontheimer, René H. Levy & Isabelle Ragueneau-Majlessi. (2017) Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings. Journal of Pharmaceutical Sciences 106:9, pages 2312-2325.
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Anton Ivanyuk, Françoise Livio, Jérôme Biollaz & Thierry Buclin. (2017) Renal Drug Transporters and Drug Interactions. Clinical Pharmacokinetics 56:8, pages 825-892.
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Javad Khalili Fard, Hossein Hamzeiy, Mohammadreza Sattari & Mohammad Ali Eghbal. (2016) Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity. Advanced Pharmaceutical Bulletin 6:4, pages 627-637.
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A. Hubeny, M. Keiser, S. Oswald, G. Jedlitschky, H. K. Kroemer, W. Siegmund & M. Grube. (2016) Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug Metabolism and Disposition 44:10, pages 1562-1568.
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S. G. Summerfield, Y. Zhang & H. Liu. (2016) Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier. Journal of Pharmacology and Experimental Therapeutics 358:2, pages 294-305.
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Yan-Yan Zhang, Houfu Liu, Scott G. SummerfieldChristopher N. LuscombeJasminder Sahi. (2016) Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System . Molecular Pharmaceutics 13:5, pages 1540-1550.
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Li Di & Edward H. Kerns. 2016. Drug-Like Properties. Drug-Like Properties 113 140 .
Priyoneel Basu, Naomi Ie, Adrienne L. Wensel, Joelle D. Baskerville, Victoria M. Smith & Michael C. Antle. (2015) Triptans attenuate circadian responses to light. European Journal of Neuroscience 42:7, pages 2489-2495.
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Houfu Liu, Na Yu, Sijie Lu, Sumito Ito, Xuan Zhang, Bhagwat Prasad, Enuo He, Xinyan Lu, Yang Li, Fei Wang, Han Xu, Gang An, Jashvant D. Unadkat, Hiroyuki Kusuhara, Yuichi Sugiyama & Jasminder Sahi. (2015) Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2– Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration. Drug Metabolism and Disposition 43:7, pages 1008-1018.
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Jennifer Lu, Veronique Michaud, Liliam Gabriela Guilarte Moya, Fleur Gaudette, Yat Hei Leung & Jacques Turgeon. (2015) Effects of β -Blockers and Tricyclic Antidepressants on the Activity of Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) . Journal of Pharmacology and Experimental Therapeutics 352:3, pages 552-558.
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Bruno Stieger & Bo Gao. (2015) Drug Transporters in the Central Nervous System. Clinical Pharmacokinetics 54:3, pages 225-242.
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Ziqiang Cheng & Qian Liu. 2015. Blood-Brain Barrier in Drug Discovery. Blood-Brain Barrier in Drug Discovery 125 145 .
Yinhui Zhou, Jingjing Yuan, Zhisong Li, Zhongyu Wang, Dan Cheng, Yingying Du, Wenlu Li, Quancheng Kan & Wei Zhang. (2015) Genetic Polymorphisms and Function of the Organic Anion-Transporting Polypeptide 1A2 and Its Clinical Relevance in Drug Disposition. Pharmacology 95:3-4, pages 201-208.
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Jian Zheng, Ting Chan, Florence Shin Gee Cheung, Ling Zhu, Michael Murray & Fanfan Zhou. (2014) PDZK1 and NHERF1 Regulate the Function of Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) by Modulating Its Subcellular Trafficking and Stability. PLoS ONE 9:4, pages e94712.
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Ramakrishna Nirogi, Devender Reddy Ajjala, Vishwottam Kandikere, Raghupathi Aleti, Hanumanth Rao Pantangi, Surya Rao Srikakolapu, Vijay Benade, Gopinadh Bhyrapuneni & Himabindu Vurimindi. (2013) LC–MS/MS method for the quantification of almotriptan in dialysates: Application to rat brain and blood microdialysis study. Journal of Pharmaceutical and Biomedical Analysis 81-82, pages 160-167.
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Douglas B. Kell, Paul D. Dobson, Elizabeth Bilsland & Stephen G. Oliver. (2013) The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today 18:5-6, pages 218-239.
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Li Di, Haojing Rong & Bo Feng. (2012) Demystifying Brain Penetration in Central Nervous System Drug Discovery. Journal of Medicinal Chemistry 56:1, pages 2-12.
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