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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 5
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Animal Pharmacokinetics and Metabolism

A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data

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Pages 468-478 | Received 01 Aug 2012, Accepted 21 Sep 2012, Published online: 15 Nov 2012

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Sicong Li, Xuting Li, Dingsheng Yuan, Bin Wang, Rui Yang, Min Zhang, Jinliang Li & Fuqiang Zeng. (2021) Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo. Xenobiotica 51:9, pages 961-967.
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Keiichi Morita, Motohiro Kato, Toshiyuki Kudo & Kiyomi Ito. (2020) In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization. Xenobiotica 50:9, pages 1064-1075.
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Ravindra V. Alluri, Rui Li & Manthena V. S. Varma. (2020) Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?. Expert Opinion on Drug Metabolism & Toxicology 16:5, pages 387-401.
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Maki Miyamoto, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano & Hideki Hirabayashi. (2017) Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver. Xenobiotica 47:12, pages 1052-1063.
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Zuzana E. Haarhoff, Melissa A. Kramer, Tatyana A. Zvyaga, Jun Zhang, Priyadeep Bhutani, Murali Subramanian & A. David Rodrigues. (2017) Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human. Xenobiotica 47:6, pages 470-478.
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Yohei Kosugi & Junzo Takahashi. (2015) Species differences and substrate specificity of CYP3A heteroactivation by efavirenz. Xenobiotica 45:4, pages 345-352.
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Mario Pellegatti. (2013) Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1171-1180.
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Articles from other publishers (4)

Nai-Rong Liu, Kai Yang, Wen-Ting Li, Zhi-Hua Pang, Qing Zhang, Jia-Jia Wang, Wen-Xi Dang, Ruo-Yong Jia, Zhi-Wei Fu, Yi-Xuan Li, Zhu-Hua Yao & Zhong-Ze Fang. (2020) Evaluation of the inhibition of chlorophenols towards human cytochrome P450 3A4 and differences among various species. Science of The Total Environment 724, pages 138187.
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Takuya Ebihara, Mitsuhiro Nishihara, Junzo Takahashi, Fumihiro Jinno & Yoshihiko Tagawa. (2018) Differences in nonclinical pharmacokinetics between species and prediction of human pharmacokinetics of TAK-272 (SCO-272), a novel orally active renin inhibitor. Biopharmaceutics & Drug Disposition 39:3, pages 175-183.
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Kenta Haraya, Motohiro Kato, Koji Chiba & Yuichi Sugiyama. (2016) Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers. Drug Metabolism and Pharmacokinetics 31:4, pages 276-284.
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Tetsuya Mitsui, Takayuki Nemoto, Taiji Miyake, Shunsuke Nagao, Kotaro Ogawa, Motohiro Kato, Masaki Ishigai & Hideyuki Yamada. (2014) A Useful Model Capable of Predicting the Clearance of Cytochrome P450 3A4 (CYP3A4) Substrates in Humans: Validity of CYP3A4 Transgenic Mice Lacking Their Own Cyp3a Enzymes. Drug Metabolism and Disposition 42:9, pages 1540-1547.
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