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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 10
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Research Article

Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats

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Pages 913-925 | Received 17 Feb 2014, Accepted 11 Apr 2014, Published online: 30 Apr 2014

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Read on this site (6)

Woo Youl Kang, Hae Won Lee, Mi-Ri Gwon, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Dong Heon Yang, Sook Jin Seong & Young-Ran Yoon. (2020) A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers. Drug Design, Development and Therapy 14, pages 2101-2111.
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Woo Youl Kang, Sook Jin Seong, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Eun Hee Kim, Dong Heon Yang, Hae Won Lee & Young-Ran Yoon. (2018) Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects. Drug Design, Development and Therapy 12, pages 3607-3615.
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Fabio Angeli, Paolo Verdecchia, Monica Trapasso, Marina Pane, Sara Signorotti & Gianpaolo Reboldi. (2018) PK/PD evaluation of fimasartan for the treatment of hypertension Current evidences and future perspectives. Expert Opinion on Drug Metabolism & Toxicology 14:5, pages 533-541.
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Mohd Yaseen Malik, Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla & Jawahar Lal. (2016) Role of enterohepatic recirculation in drug disposition: cooperation and complications. Drug Metabolism Reviews 48:2, pages 281-327.
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Ji-Yoon Lee, Young Jae Choi, Soo Jin Oh, Yong Ha Chi, Soo Heui Paik, Ki Ho Lee, Jae-Kyung Jung, Chang Seon Ryu, Kwon-Bok Kim, Dong-Hyun Kim, Young-Ran Yoon & Sang Kyum Kim. (2016) Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica 46:1, pages 40-51.
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Eun-Sook Jeong, Yang-Weon Kim, Hyo-Ji Kim, Ho-Jung Shin, Jae-Gook Shin, Kwang Hee Kim, Yong Ha Chi, Soo Heui Paik & Dong-Hyun Kim. (2015) Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3. Xenobiotica 45:1, pages 10-18.
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Articles from other publishers (13)

So-Yeon Jeon, Ji-Hyeon Jeon, Jin-Hyang Park, Jihoon Lee, Minyeong Pang, Min-Koo Choi & Im-Sook Song. (2022) Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fimasartan, Amlodipine, and Hydrochlorothiazide, in Rats Using LC-MS/MS and Subsequent Application to Pharmacokinetic Drug Interaction with Red Ginseng Extract. Toxics 10:10, pages 576.
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Eun Joo Cho, Ki Chul Sung, Seok Min Kang, Mi-Seung Shin, Seung Jae Joo & Jeong Bae Park. (2019) Fimasartan reduces clinic and home pulse pressure in elderly hypertensive patients: A K-MetS study. PLOS ONE 14:4, pages e0214293.
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Akshyaya Pradhan, Vikas Gupta & Rishi Sethi. (2019) Fimasartan: A new armament to fight hypertension. Journal of Family Medicine and Primary Care 8:7, pages 2184.
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Wonken Choung, Hui Jin Jung, Eun Hye Nam, Deokmo Yang, Byoungwook Yoo, Hyukjoon Choi, Bo Ram Lee, Min Park, Su Min Jang, Jae Soo Lim, Kyung-Hee Kim, Jungwook Chin, Kyungjin Jung, Geumwoo Lee & Seong Heon Kim. (2018) Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPARγ derived from the AT1R antagonist, Fimasartan. Bioorganic & Medicinal Chemistry Letters 28:19, pages 3155-3160.
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Young Jae Choi, Ji-Yoon Lee, Chang Seon Ryu, Yong Ha Chi, Soo Heui Paik & Sang Kyum Kim. (2018) Role of cytochrome P450 enzymes in fimasartan metabolism in vitro. Food and Chemical Toxicology 115, pages 375-384.
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Jürgen B. Bulitta, Soo Heui Paik, Yong Ha Chi, Tae Hwan Kim, Soyoung Shin, Cornelia B. Landersdorfer, Yuanyuan Jiao, Rajbharan Yadav & Beom Soo Shin. (2017) Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling. European Journal of Pharmaceutical Sciences 107, pages 32-44.
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Choon OK KimSangil JeonSeunghoon HanTaegon HongMin Soo ParkYoung-Ran YoonDong-Seok Yim. (2017) Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis. Translational and Clinical Pharmacology 25:1, pages 43.
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Tae Hwan Kim, Min Gi Kim, Soyoung Shin, Yong-Ha Chi, Soo-Heui Paik, Joo-Han Lee, Sun Dong Yoo, Yu Seok Youn, Jürgen B. Bulitta, Sang Hoon Joo, Seok Won Jeong, Kwon-Yeon Weon & Beom Soo Shin. (2016) Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats. BMC Pharmacology and Toxicology 17:1.
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Hae-Young Lee & Byung-Hee Oh. (2016) Fimasartan: A New Angiotensin Receptor Blocker. Drugs 76:10, pages 1015-1022.
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Hairong Wang, Xiaobin Li, Haoyu Ye, Neng Qiu, Liang Ma, Chunyu Wang, Qiunan Yang, Minghai Tang, Li Wan & Lijuan Chen. (2016) Characterization of In Vivo Metabolites of a Potential Anti-obesity Compound, the 3-Methyl-1H-Purine-2,6-Dione Derivative C-11, Employing Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. Chromatographia 79:11-12, pages 693-702.
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Jong-Lyul Ghim, Soo Heui Paik, M. Hasanuzzaman, Yong Ha Chi, Hyang-Ki Choi, Dong-Hyun Kim & Jae-Gook Shin. (2016) Absolute bioavailability and pharmacokinetics of the angiotensin II receptor antagonist fimasartan in healthy subjects. The Journal of Clinical Pharmacology 56:5, pages 576-580.
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Ying-Yuan Lu, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Hong Ren, Ya-Qing Lou, Chuang Lu & Guo-Liang Zhang. (2015) Development and validation of a high performance liquid chromatography method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor and its application to a pharmacokinetic study in rats. Biomedical Chromatography 29:10, pages 1548-1552.
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Tae Hwan Kim, Soyoung Shin, Cornelia B. Landersdorfer, Yong Ha Chi, Soo Heui Paik, Jayhyuk Myung, Rajbharan Yadav, Stefan Horkovics-Kovats, Jürgen B. Bulitta & Beom Soo Shin. (2015) Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans. The AAPS Journal 17:5, pages 1210-1223.
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