Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 10
495
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats

, , , , , , , , , , , & show all
Pages 913-925 | Received 17 Feb 2014, Accepted 11 Apr 2014, Published online: 30 Apr 2014

References

  • Beermann B. (1973). Value of plasma-digoxin estimation. Lancet 1:375
  • Chi YH, Lee H, Paik SH, et al. (2011). Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in the fasted and fed states in healthy subjects. Am J Cardiovasc Drugs 11:335–46
  • Christ DD, Wong PC, Wong YN, et al. (1994). The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) in the dog. J Pharmacol Exp Ther 268:1199–205
  • Davi H, Tronquet C, Miscoria G, et al. (2000). Disposition of irbesartan, an angiotensin II AT1-receptor antagonist, in mice, rats, rabbits, and macaques. Drug Metab Dispos 28:79–88
  • Deguchi T, Watanabe N, Kurihara A, et al. (2011). Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach. Drug Metab Dispos 39:820–9
  • Ieiri I, Nishimura C, Maeda K, et al. (2011). Pharmacokinetic and pharmacogenomic profiles of telmisartan after the oral microdose and therapeutic dose. Pharmacogenet Genom 21:495–505
  • Jeon H, Lim KS, Shin KH, et al. (2012). Assessment of the drug-drug interactions between fimasartan and hydrochlorothiazide in healthy volunteers. J Cardiovasc Pharmacol 59:84–91
  • Kim JH, Lee JH, Paik SH, et al. (2012a). Fimasartan, a novel angiotensin II receptor antagonist. Arch Pharm Res 35:1123–6
  • Kim TW, Yoo BW, Lee JK, et al. (2012b). Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists. Bioorg Med Chem Lett 22:1649–54
  • Lane A, Engmann E, Bryson S, et al. (2005a). Single dose pharmacokinetics (PK) and pharmacodynamics (PD) of BR-A-657, an angiotensin II (AII) antagonist. Clin Pharmacol Ther 77:P59
  • Lane A, Kleinermanns D, Bryson S, et al. (2005b). Multiple dose pharmacokinetics (PK) and pharmacodynamics (PD) of BR-A-657, an angiotensin II (AII) antagonist. Clin Pharmacol Ther 77:P58
  • Lee HW, Lim MS, Seong SJ, et al. (2011). Effect of age on the pharmacokinetics of fimasartan (BR-A-657). Expert Opin Drug Metab Toxicol 7:1337–44
  • Lee J, Han S, Jeon S, et al. (2013). Pharmacokinetic–pharmacodynamic model of fimasartan applied to predict the influence of a high fat diet on its blood pressure-lowering effect in healthy subjects. Eur J Clin Pharmacol 69:11–20
  • Lee SE, Kim YJ, Lee HY, et al., Investigators. (2012). Efficacy and tolerability of fimasartan, a new angiotensin receptor blocker, compared with losartan (50/100 mg): a 12-week, phase III, multicenter, prospective, randomized, double-blind, parallel-group, dose escalation clinical trial with an optional 12-week extension phase in adult Korean patients with mild-to-moderate hypertension. Clin Ther 34:552–68, 568e1–9
  • Miura M, Satoh S, Inoue K, et al. (2009). Telmisartan pharmacokinetics in Japanese renal transplant recipients. Clin Chim Acta 399:83–7
  • Park JB, Sung KC, Kang SM, Cho EJ. (2013). Safety and efficacy of fimasartan in patients with arterial hypertension (Safe-KanArb study): an open-label observational study. Am J Cardiovasc Drugs 13:47–56
  • Roberts MS, Magnusson BM, Burczynski FJ, Weiss M. (2002). Enterohepatic circulation: physiological, pharmacokinetic and clinical implications. Clin Pharmacokinet 41:751–90
  • Shin BS, Kim TH, Paik SH, et al. (2011). Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography–tandem mass spectrometry. Biomed Chromatogr 25:1208–14
  • Veng Pedersen P. (1981). Pharmacokinetic analysis by linear system approach I: cimetidine bioavailability and second peak phenomenon. J Pharm Sci 70:32–8
  • Yi S, Kim JW, Kim TE, et al. (2011a). Effect of multiple doses of fimasartan, an angiotensin II receptor antagonist, on the steady-state pharmacokinetics of digoxin in healthy volunteers. Int J Clin Pharmacol Ther 49:321–7
  • Yi S, Kim TE, Yoon SH, et al. (2011b). Pharmacokinetic interaction of fimasartan, a new angiotensin II receptor antagonist, with amlodipine in healthy volunteers. J Cardiovasc Pharmacol 57:682–9
  • Zhou H. (2003). Pharmacokinetic strategies in deciphering atypical drug absorption profiles. J Clin Pharmacol 43:211–27

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.