Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 6
Submit an article Journal homepage
674
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Biotransformation and mass balance of the SGLT2 inhibitor empagliflozin in healthy volunteers

Lin-Zhi ChenBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA, Correspondence[email protected]
,
Arvid JungnikBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, and
,
Yanping MaoBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA,
,
Elsy PhilipBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA,
,
Dale SharpBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA,
,
Anna UnseldBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, and
,
Leo SemanBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA,
,
Hans-Jürgen WoerleBoehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany
&
Sreeraj MachaBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA,
show all
Pages 520-529 | Received 21 Oct 2014, Accepted 12 Dec 2014, Published online: 30 Dec 2014

Citations (17)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Baptist Gallwitz. (2017) A safety evaluation of empagliflozin plus linagliptin for treating type 2 diabetes. Expert Opinion on Drug Safety 16:12, pages 1399-1405.
Read now
Atsunori Miyata, Masatoshi Hasegawa, Kenji Hachiuma, Haruyuki Mori, Nobuko Horiuchi, Akiko Mizuno-Yasuhira, Yukihiro Chino, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa, Yasuhiro Nakai & Jun-ichi Yamaguchi. (2017) Metabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, in humans. Xenobiotica 47:4, pages 332-345.
Read now

Articles from other publishers (15)

Anil Kumar Goud Thallapalli & Ram Mohan Manda. (2023) Development and validation of Empagliflozin and Linagliptin simultaneous estimation in rat plasma using freezing lipid precipitation and SCX-SPE assisted HPLC–MS/MS method and its application in pharmacokinetic studies. Analytical Sciences.
Crossref
Yu Zhang, Panpan Xie, Yamei Li, Zhixing Chen & Aixin Shi. (2023) Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches. Frontiers in Pharmacology 14.
Crossref
Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Sha Chen, Ruben Coronel, Markus W. Hollmann, Nina C. Weber & Coert J. Zuurbier. (2022) Direct cardiac effects of SGLT2 inhibitors. Cardiovascular Diabetology 21:1.
Crossref
JÉSSICA B. DE JESUS, RAISSA A. DA CONCEIÇÃO, THAYNÁ R. MACHADO, MARIA L.C. BARBOSA, THAISA F.S. DOMINGOS, LUCIO M. CABRAL, CARLOS R. RODRIGUES, BÁRBARA ABRAHIM-VIEIRA & ALESSANDRA M.T. DE SOUZA. (2022) Toxicological assessment of SGLT2 inhibitors metabolites using in silico approach. Anais da Academia Brasileira de Ciências 94:suppl 3.
Crossref
Gangireddy Navitha Reddy, Chenkual Laltanpuii & Rajesh Sonti. (2021) Review on in vivo profiling of drug metabolites with LC-MS/MS in the past decade . Bioanalysis 13:22, pages 1697-1722.
Crossref
Ju-Hyun Kim, Dong Kyun Kim, Won-Gu Choi, Hye-Young Ji, Ji-Soo Choi, Im-Sook Song, Sangkyu Lee & Hye Suk Lee. (2020) In Vitro Metabolism of DWP16001, a Novel Sodium-Glucose Cotransporter 2 Inhibitor, in Human and Animal Hepatocytes. Pharmaceutics 12:9, pages 865.
Crossref
Namyi Gu, Sang-In Park, Hyewon Chung, Xuanyou Jin, SeungHwan Lee & Tae-Eun Kim. (2020) Possibility of pharmacokinetic drug interaction between a DPP-4 inhibitor and a SGLT2 inhibitor. Translational and Clinical Pharmacology 28:1, pages 17.
Crossref
Tamara Y. Milder, Sophie L. Stocker, Dorit Samocha-Bonet, Richard O. Day & Jerry R. Greenfield. (2019) Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes—cardiovascular and renal benefits in patients with chronic kidney disease. European Journal of Clinical Pharmacology 75:11, pages 1481-1490.
Crossref
Bruna Carolina Lui Dias, Mariana Millan Fachi, Michel Leandro Campos, Flávia Lada Degaut Degaut, Rosângela Gonçalves Peccinini & Roberto Pontarolo. (2019) A new HPLC–MS/MS method for the simultaneous quantification of SGLT2 inhibitors and metformin in plasma and its application to a pharmacokinetic study in healthy volunteers. Biomedical Chromatography.
Crossref
Priyanka A. Shah, Pranav S. Shrivastav & Archana George. (2019) Mixed-mode solid phase extraction combined with LC-MS/MS for determination of empagliflozin and linagliptin in human plasma. Microchemical Journal 145, pages 523-531.
Crossref
James E. Frampton. (2018) Empagliflozin: A Review in Type 2 Diabetes. Drugs 78:10, pages 1037-1048.
Crossref
Paresh Dandona & Ajay Chaudhuri. (2017) Sodium-glucose co-transporter 2 inhibitors for type 2 diabetes mellitus: An overview for the primary care physician. International Journal of Clinical Practice 71:5, pages e12937.
Crossref
Javier Saurina & Sonia Sentellas. (2017) Strategies for metabolite profiling based on liquid chromatography. Journal of Chromatography B 1044-1045, pages 103-111.
Crossref
John E. Anderson, Eugene E. WrightJr.Jr. & Charles F. ShaeferJr.Jr.. (2016) Empagliflozin: Role in Treatment Options for Patients with Type 2 Diabetes Mellitus. Diabetes Therapy 8:1, pages 33-53.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.