Xenobiotica, Volume 45, Issue 6 (2015)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 45, Issue 6 (2015)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Volume 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

Research Article

Article
In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism
Christian Atsriku, Matthew Hoffmann, Mehran Moghaddam, Gondi Kumar & Sekhar Surapaneni
Pages: 465-480
Published online: 05 Dec 2014
AbstractforIn vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism | Full Text | References | PDF (2.4 MB)
  • 399 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
Effects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro
Yue Yu, Yan Liu, Qian Li, Jiahui Sun, Haiou Lin & Gaofeng Liu
Pages: 481-487
Published online: 12 Dec 2014
AbstractforEffects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro | Full Text | References | PDF (481.8 KB)
  • 212 Views
  • 4 CrossRef citations
  • 0Altmetric
Article
In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats
Kazuo Oda, Naoyuki Nakada & Yasuhisa Nagasaka
Pages: 488-494
Published online: 24 Dec 2014
AbstractforIn vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats | Full Text | References | PDF (531.2 KB)
  • 371 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
Characterization of bovine phenol sulfotransferases: evidence of a major role for SULT1B1 in the liver
Kanika V. Choughule, Charles W. Locuson & Michael W. H. Coughtrie
Pages: 495-502
Published online: 24 Dec 2014
AbstractforCharacterization of bovine phenol sulfotransferases: evidence of a major role for SULT1B1 in the liver | Full Text | References | PDF (590.2 KB)
  • 182 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Identification and functional characterization of novel feline cytochrome P450 2A
Gaku Okamatsu, Tetsuya Komatsu, Akira Kubota, Takenori Onaga, Tsuyoshi Uchide, Daiji Endo, Rikio Kirisawa, Guojun Yin, Hiroki Inoue, Takio Kitazawa, Yasuhiro Uno & Hiroki Teraoka
Pages: 503-510
Published online: 30 Dec 2014
AbstractforIdentification and functional characterization of novel feline cytochrome P450 2A | Full Text | References | PDF (683 KB)
  • 179 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10
Darja Gramec Skledar, Johanna Troberg, Jason Lavdas, Lucija Peterlin Mašič & Moshe Finel
Pages: 511-519
Published online: 30 Dec 2014
AbstractforDifferences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10 | Full Text | References | PDF (598.2 KB)
  • 528 Views
  • 37 CrossRef citations
  • 0Altmetric
Article
Biotransformation and mass balance of the SGLT2 inhibitor empagliflozin in healthy volunteers
Lin-Zhi Chen, Arvid Jungnik, Yanping Mao, Elsy Philip, Dale Sharp, Anna Unseld, Leo Seman, Hans-Jürgen Woerle & Sreeraj Macha
Pages: 520-529
Published online: 30 Dec 2014
AbstractforBiotransformation and mass balance of the SGLT2 inhibitor empagliflozin in healthy volunteers | Full Text | References | PDF (1.7 MB)
  • 664 Views
  • 17 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetics and tissue distribution study of novel potent antiplatelet agent S007-867 in mice using HPLC-MS/MS
Hardik Chandasana, Yashpal S. Chhonker, Yarra Durga Prasad, Tulsankar Sachin Laxman, K. S. Anil Kumar, Dinesh K. Dikshit & Rabi S. Bhatta
Pages: 530-537
Published online: 02 Apr 2015
AbstractforPharmacokinetics and tissue distribution study of novel potent antiplatelet agent S007-867 in mice using HPLC-MS/MS | Full Text | References | PDF (560.8 KB)
  • 193 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
The mechanism of rapamycin in the intervention of paraquat-induced acute lung injury in rats
Da Chen, Guangyu Jiao, Tao Ma, Xiaowei Liu, Chen Yang & Zhi Liu
Pages: 538-546
Published online: 19 Dec 2014
AbstractforThe mechanism of rapamycin in the intervention of paraquat-induced acute lung injury in rats | Full Text | References | PDF (1 MB) | Supplemental
  • 176 Views
  • 10 CrossRef citations
  • 0Altmetric
Article
Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats
Liyue Huang, Xingwen Li, Jonathan Roberts, Brett Janosky & Min-Hwa Jasmine Lin
Pages: 547-555
Published online: 24 Dec 2014
AbstractforDifferential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats | Full Text | References | PDF (388 KB)
  • 538 Views
  • 19 CrossRef citations
  • 0Altmetric
Article
Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats
Keigo Kosaka, Tomoko Watanabe, Takeshi Susukida, Shigeki Aoki, Shuichi Sekine, Toshiyuki Kume & Kousei Ito
Pages: 556-562
Published online: 24 Dec 2014
AbstractforKey determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats | Full Text | References | PDF (570.3 KB)
  • 280 Views
  • 4 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Developmental stage and infection status may affect drug distribution in the prostate of rats
Ziyang Xu et al.
Article | Published online: 25 Apr 2024
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle
Paula Ichinose et al.
Article | Published online: 25 Apr 2024
Academic foreign compound metabolism – ‘quo vadis’?
S. C. Mitchell et al.
Rapid Communication | Published online: 24 Apr 2024
Open Access
mRNA expression levels of cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the epidermis: a focus on individual differences among Japanese individuals
Hiroko Makihara et al.
Article | Published online: 24 Apr 2024
View all latest articles