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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 12
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Animal Pharmacokinetics and Metabolism

Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent

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Pages 1105-1115 | Received 12 Mar 2015, Accepted 16 Apr 2015, Published online: 06 Jul 2015

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Read on this site (3)

Daisuke Yabe, Yoshiyuki Hamamoto, Yusuke Seino, Hitoshi Kuwata, Takeshi Kurose & Yutaka Seino. (2017) Sodium glucose co-transporter 2 inhibitor luseogliflozin in the management of type 2 diabetes: a drug safety evaluation. Expert Opinion on Drug Safety 16:10, pages 1211-1218.
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Yukihiro Chino, Masatoshi Hasegawa, Yoshiki Fukasawa, Yoko Mano, Kagumi Bando, Atsunori Miyata, Yasuhiro Nakai, Hiromi Endo & Jun-ichi Yamaguchi. (2017) In vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor. Xenobiotica 47:4, pages 314-323.
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Atsunori Miyata, Masatoshi Hasegawa, Kenji Hachiuma, Haruyuki Mori, Nobuko Horiuchi, Akiko Mizuno-Yasuhira, Yukihiro Chino, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa, Yasuhiro Nakai & Jun-ichi Yamaguchi. (2017) Metabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, in humans. Xenobiotica 47:4, pages 332-345.
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Articles from other publishers (9)

Dan Nakano, Jun Akiba, Tsubasa Tsutsumi, Machiko Kawaguchi, Takafumi Yoshida, Hironori Koga & Takumi Kawaguchi. (2022) Hepatic expression of sodium–glucose cotransporter 2 (SGLT2) in patients with chronic liver disease. Medical Molecular Morphology 55:4, pages 304-315.
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Anirudh Manoj, Subham Das, Anu Kunnath Ramachandran, Angel T Alex & Alex Joseph. (2020) SGLT2 inhibitors, an accomplished development in field of medicinal chemistry: an extensive review. Future Medicinal Chemistry 12:21, pages 1961-1990.
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Kashif Haider, Ankita Pathak, Ankit Rohilla, Md Rafi Haider, Kamal Ahmad & M. Shahar Yar. (2019) Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review. European Journal of Medicinal Chemistry 184, pages 111773.
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Kohnosuke Kinoshita, Motoki Ochi, Katsuya Iwata, Misako Fukasawa & Jun‐ichi Yamaguchi. (2019) Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia. Pharmacology Research & Perspectives 7:5.
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Shinji Kobuchi, Megumi Matsuno, Momoko Kawamoto, Naoto Kojima, Yukako Ito, Masayuki Yamashita & Toshiyuki Sakaeda. (2017) A simple and rapid LC–MS/MS method for quantitation of luseogliflozin in rat plasma and its application to a PK study. Bioanalysis 9:2, pages 163-171.
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Yoshishige SamukawaMasaru MutohShi ChenNobuo Mizui. (2017) Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of Luseogliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, in Japanese Patients with Type 2 Diabetes Mellitus. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:8, pages 1207-1218.
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Tushar Madaan, Mohd. Akhtar & Abul Kalam Najmi. (2016) Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. European Journal of Pharmaceutical Sciences 93, pages 244-252.
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Soichi Sakai, Kohei Kaku, Yutaka Seino, Nobuya Inagaki, Masakazu Haneda, Takashi Sasaki, Atsushi Fukatsu, Haruka Kakiuchi & Yoshishige Samukawa. (2016) Efficacy and Safety of the SGLT2 Inhibitor Luseogliflozin in Japanese Patients With Type 2 Diabetes Mellitus Stratified According to Baseline Body Mass Index: Pooled Analysis of Data From 52-Week Phase III Trials. Clinical Therapeutics 38:4, pages 843-862.e9.
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Minoru Sasaki, Takanobu Sakurai, Aiko Ishii, Kenta Matsue, Yutaka Nakanishi, Shunsuke Tsutsumi & Yasushi Sato. (2016) Evaluation of potential activity of luseogliflozin on vascular proliferation in the mesenteric lymph node with or without vascular tumors in Sprague-Dawley rats in a carcinogenicity study. Journal of Toxicologic Pathology 29:2, pages 85-93.
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