Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 12
1,270
Views
12
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent

, , , , , , & show all
Pages 1105-1115 | Received 12 Mar 2015, Accepted 16 Apr 2015, Published online: 06 Jul 2015

References

  • Hediger MA, Rhoads DB. (1994). Molecular physiology of sodium glucose cotransporters. Physiol Rev 74:993–1026
  • Kadokura T, Saito M, Utsuno A, et al. (2011). Ipragliflozin (ASP1941), a selective sodium-dependent glucose cotransporter 2 inhibitor, safely stimulates urinary glucose excretion without inducing hypoglycemia in healthy Japanese subjects. Diabetol Int 2:172–82
  • Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, et al. (2010). (1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-d-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment. J Med Chem 53:3247–61
  • Kanai Y, Lee WS, You G, et al. (1994). The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for d-glucose. J Clin Invest 93:397–404
  • Kim GW, Chung SH. (2014). Clinical implication of SGLT2 inhibitors in type 2 diabetes. Arch Pharm Res 37:957–66
  • Kurosaki E, Ogasawara H. (2013). Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: preclinical and clinical data. Pharmacol Ther 139:51–9
  • Liu J, Lee T, DeFronzo R. (2012). Why Do SGLT2 inhibitors inhibit only 30–50% of renal glucose reabsorption in humans? Diabetes 61:2199–204
  • Mizuno-Yasuhira A, Nakai Y, Gunji E, et al. (2014). A strategy for assessing potential drug–drug interactions of a concomitant agent against a drug absorbed via an intestinal transporter in humans. Drug Metab Dispos 42:1456–65
  • Musso G, Gambino R, Cassader M, et al. (2012). A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med 44:375–93
  • Rahmoune H, Thompson PW, Ward JM, et al. (2005). Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 54:3427–34
  • Sabolic I, Vrhovac I, Eror DB, et al. (2012). Expression of Na+-d-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol 15:C1174–88
  • Sarashina A, Koiwai K, Seman LJ, et al. (2013). Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in healthy Japanese subjects. Drug Metab Pharmacokinet 28:213–19
  • Sasaki T, Seino Y, Fukatsu A, Sakai S, et al. (2014). Safety, Pharmacokinetics, and pharmacodynamics of single and multiple luseogliflozin dosing in healthy japanese males: a randomized, single-blind, placebo-controlled trial. Adv Ther 31:345–61
  • Scheen AJ. (2014). Drug-drug interactions with sodium-glucose cotransporters type 2 (SGLT2) inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes mellitus. Clin Pharmacokinet 53:295–304
  • Schwab D, Portron A, Backholer Z, et al. (2013). A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans. Clin Pharmacokinet 52:463–73
  • Seino Y. (2014). Luseogliflozin for the treatment of type 2 diabetes. Expert Opin Pharmacother 15:2741–9
  • Washburn WN, Poucher SM. (2013). Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus. Expert Opin Investig Drugs 22:463–86
  • Yamamoto K, Uchida S, Kitano K, et al. (2011). TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity. Br J Pharmacol 164:181–91

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.