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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 2
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General Xenobiochemistry

In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs

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Pages 126-131 | Received 31 Mar 2015, Accepted 19 May 2015, Published online: 15 Jun 2015

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Pony Yee-Chee Chai, Chian-Ting Chang, Yi-Hua Chen, Hui-Yu Chen & Ka-Wai Tam. (2021) Effect of drug interactions between carbapenems and valproate on serum valproate concentration: a systematic review and meta-analysis. Expert Opinion on Drug Safety 20:2, pages 215-223.
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Xuping Yang, Zhenwei Jiang, Yan Jiang, Jing Ling, Lulu Dong, Sulan Zou, Rong Chen & Nan Hu. (2023) Determination of valproic acid and its six metabolites in human serum using LC–MS/MS and application to interaction with carbapenems in epileptic patients. Biomedical Chromatography 37:3.
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Joachim Andreas Koeck, Heike Hilgarth, Andreas von Ameln-Mayerhofer, Damaris Meyn, Ruediger Warlich, Andreas Münstedt, Dagmar Horn & Christina König. (2021) Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study. Antibiotics 10:11, pages 1330.
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Gaetano Zaccara & Simona Lattanzi. (2021) A review of pharmacokinetic drug interactions between antimicrobial and antiseizure medications in children. Epileptic Disorders 23:2, pages 229-256.
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Osama Al-Quteimat & Alla Laila. (2019) Valproate Interaction With Carbapenems: Review and Recommendations. Hospital Pharmacy 55:3, pages 181-187.
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Caitlin Thomas, James Priano & Tracey L. Smith. (2020) Meropenem as an antidote for intentional valproic acid overdose. The American Journal of Emergency Medicine 38:3, pages 690.e1-690.e2.
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Despina Tsortouktzidis, Kathleen Grundke, Claudia Till, Anne Korwitz-Reichelt & Jörn Oliver Sass. (2019) Acylpeptide hydrolase (APEH) sequence variants with potential impact on the metabolism of the antiepileptic drug valproic acid. Metabolic Brain Disease 34:6, pages 1629-1634.
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David E. Nix & Keith Gallicano. 2018. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions 285 315 .
Eiko Suzuki, Kumiko Koyama, Daisuke Nakai, Ryoya Goda, Hiroshi Kuga & Kan Chiba. (2017) Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics. European Journal of Drug Metabolism and Pharmacokinetics 42:6, pages 965-972.
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Takeshi Ishikawa, Hiroki Otaki, Satoshi Mizuta, Masami Kuriyama, Osamu Onomura, Norihide Higuchi, Mihoko N. Nakashima, Mikiro Nakashima & Kaname Ohyama. (2017) Computational study of the competitive binding of valproic acid glucuronide and carbapenem antibiotics to acylpeptide hydrolase. Drug Metabolism and Pharmacokinetics 32:4, pages 201-207.
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Z.-P. Wen, S.-S. Fan, C. Du, T. Yin, B.-T. Zhou, Z.-F. Peng, Y.-Y. Xie, W. Zhang, Y. Chen, J. Xiao & X.-P. Chen. (2017) Drug-drug interaction between valproic acid and meropenem: a retrospective analysis of electronic medical records from neurosurgery inpatients. Journal of Clinical Pharmacy and Therapeutics 42:2, pages 221-227.
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Peter Bede, Diane Lawlor, Damodar Solanki & Norman Delanty. (2017) Carbapenems and valproate: A consumptive relationship. Epilepsia Open 2:1, pages 107-111.
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Zhi Peng Wen, Shuang Shi Fan, Can Du, Tao Yin, Bo Ting Zhou, Ze Feng Peng, Yuan Yang Xie, Wei Zhang, Yao Chen, Jie Tang, Jian Xiao & Xiao Ping Chen. (2016) Influence of acylpeptide hydrolase polymorphisms on valproic acid level in Chinese epilepsy patients. Pharmacogenomics 17:11, pages 1219-1225.
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