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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 2
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General Xenobiochemistry

In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs

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Pages 126-131 | Received 31 Mar 2015, Accepted 19 May 2015, Published online: 15 Jun 2015

References

  • De Turck BJ, Diltoer MW, Cornelis PJ, et al. (1998). Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin. J Antimicrob Chemother 42:563–4
  • Haroutiunian S, Ratz Y, Rabinovich B, et al. (2009). Valproic acid plasma concentration decreases in a dose-independent manner following administration of meropenem: a retrospective study. J Clin Pharmacol 49:1363–9
  • Lunde JL, Nelson RE, Storandt HF. (2007). Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy. Pharmacotherapy 27:1202–5
  • Mori H, Takahashi K, Mizutani T. (2007). Interaction between valproic acid and carbapenem antibiotics. Drug Metab Rev 39:647–57
  • Nagai K, Shimizu T, Togo A, et al. (1997). Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron. J Antimicrob Chemother 39:295–6
  • Nakajima Y, Mizobuchi M, Nakamura M, et al. (2004). Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats. Drug Metab Dispos 32:1383–91
  • Rimmer EM, Richens A. (1985). An update on sodium valproate. Pharmacotherapy 5:171–84
  • Suzuki E, Nakai D, Yamamura N, et al. (2011). Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid. Xenobiotica 41:958–63
  • Suzuki E, Yamamura N, Ogura Y, et al. (2010). Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics. Drug Metab Dispos 38:1538–44
  • Taha FA, Hammond DN, Sheth RD. (2013). Seizures from valproate-carbapenem interaction. Pediatr Neurol 49:279–81
  • Yokogawa K, Iwashita S, Kubota A, et al. (2001). Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharm Res 18:1320–6

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