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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 6
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General Xenobiochemistry

In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans

Kazutaka SekiguchiDrug Metabolism & Pharmacokinetics, Research Laboratory for Development, Shionogi & Co., Ltd., Osaka, Japan and Correspondence[email protected]
,
Takushi KanazuDrug Metabolism & Pharmacokinetics, Research Laboratory for Development, Shionogi & Co., Ltd., Osaka, Japan and
,
Norie MurayamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
,
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
&
Yoshitaka YamaguchiDrug Metabolism & Pharmacokinetics, Research Laboratory for Development, Shionogi & Co., Ltd., Osaka, Japan and
Pages 495-502 | Received 04 Aug 2015, Accepted 02 Sep 2015, Published online: 18 Dec 2015

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Kanami Shimura, Norie Murayama, Saki Tanaka, Shunsuke Onozeki & Hiroshi Yamazaki. (2019) Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates. Xenobiotica 49:5, pages 557-562.
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Articles from other publishers (2)

Benjamin Brennecke, Thais Gazzi, Kenneth Atz, Jürgen Fingerle, Pascal Kuner, Torsten Schindler, Guy de Weck, Marc Nazaré & Uwe Grether. (2021) Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010. Pharmaceutical Patent Analyst 10:3, pages 111-163.
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John O. Miners, Andrew Rowland, Jonathan J. Novak, Kimberly Lapham & Theunis C. Goosen. (2021) Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping. Pharmacology & Therapeutics 218, pages 107689.
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