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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 11
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General Xenobiochemistry

Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine

Shotaro UeharaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Yasuhiro UnoPharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd, Kainan, Wakayama, Japan,
,
Takashi InoueDepartment of Applied Developmental Biology, Central Institute for Experimental Animals, Kawasaki, Japan, and
,
Eriko OkamotoLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Erika SasakiDepartment of Applied Developmental Biology, Central Institute for Experimental Animals, Kawasaki, Japan, and ;Keio Advanced Research Center, Keio University, Minato-Ku, Tokyo, Japan
&
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, Correspondence[email protected]
Pages 977-985 | Received 23 Dec 2015, Accepted 21 Jan 2016, Published online: 22 Feb 2016

Citations (13)

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Kazuyuki Nakanishi, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2018) Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. Xenobiotica 48:8, pages 757-763.
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Shotaro Uehara, Yukako Yuki, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2018) Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines. Xenobiotica 48:4, pages 342-347.
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Shotaro Uehara, Yasuhiro Uno, Sakura Ishii, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2017) Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues. Xenobiotica 47:7, pages 553-561.
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Articles from other publishers (10)

Jinrui Liu, Wenfei Xie, Jinyu Mei, Fangkai Du, Xuecai Tan & Shaogang Liu. (2023) Real-time tracking of endogenous CYP2J2 by red-emitting aggregation-induced emission probe with large Stokes shift. Dyes and Pigments 213, pages 111189.
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Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka & Hiroshi Yamazaki. (2022) Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes . Drug Metabolism and Disposition 50:11, pages 1434-1441.
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Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 329 364 .
Yanpeng Dai, Tianzi Xue, Hefang Ji, Pan Zhang, Dongdong Zhang & Zhengjian Qi. (2021) In situ target enzyme-activated near-infrared fluorescent probe: A case study of CYP2J2 using three-fragmentary molecular assembly engineering. Sensors and Actuators B: Chemical 328, pages 129034.
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Rajagopal N. Aravalli & Clifford J. Steer. (2020) Utility of Common Marmoset (Callithrix jacchus) Embryonic Stem Cells in Liver Disease Modeling, Tissue Engineering and Drug Metabolism. Genes 11:7, pages 729.
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Shotaro Uehara, Yasuhiro Uno & Hiroshi Yamazaki. (2020) The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function. Biochemical Pharmacology 171, pages 113721.
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Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki. (2019) Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model. Current Drug Metabolism 20:2, pages 103-113.
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Kazuyuki Nakanishi, Shotaro Uehara, Takashi Kusama, Takashi Inoue, Kanami Shimura, Yusuke Kamiya, Norie Murayama, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki. (2018) In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants. Biochemical Pharmacology 152, pages 272-278.
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K. Sandy Pang, Qi Joy Yang & Keumhan Noh. (2017) Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling. Biopharmaceutics & Drug Disposition 38:3, pages 231-250.
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Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2016) Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes. Biochemical Pharmacology 121, pages 1-7.
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