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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 5
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Original Article

Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes

A. Chadha Bio-organic Laboratory, Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India
&
K. Madhava Madyastha Bio-organic Laboratory, Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India
Pages 365-374 | Received 05 May 1983, Published online: 30 Sep 2009

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José Fernando Rinaldi de Alvarenga, Brunna Genaro, Bruna Lamesa Costa, Eduardo Purgatto, Claudine Manach & Jarlei Fiamoncini. (2023) Monoterpenes: current knowledge on food source, metabolism, and health effects. Critical Reviews in Food Science and Nutrition 63:10, pages 1352-1389.
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G. J. Pass, S. McLean, I. Stupans & N. Davies. (2001) Microsomal metabolism of the terpene 1,8-cineole in the common brushtail possum (Trichosurus vulpecula), koala (Phascolarctos cinereus), rat and human. Xenobiotica 31:4, pages 205-221.
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T. Ishida, M. Toyota & Y. Asakawa. (1989) Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (−)-perillaldehyde, (−)-myrtenal, cuminaldehyde, thujone, and (±)-carvone in rabbits. Xenobiotica 19:8, pages 843-855.
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B. Moorthy, P. Madyastha & K. M. Madyastha. (1989) Metabolism of a monoterpene ketone, R-(+)-pulegone—a hepatotoxin in rat. Xenobiotica 19:2, pages 217-224.
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K. Madhava Madyastha & V. Srivatsan. (1987) Metabolism of β-myrcene in vivo and in vitro: its effects on rat-liver microsomal enzymes. Xenobiotica 17:5, pages 539-549.
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Crossref
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Crossref
Sherehan M. Ibrahim, Ezzedin S. El- Denshary & Dalaal M. Abdallah. (2015) Geraniol, Alone and in Combination with Pioglitazone, Ameliorates Fructose-Induced Metabolic Syndrome in Rats via the Modulation of Both Inflammatory and Oxidative Stress Status. PLOS ONE 10:2, pages e0117516.
Crossref
Sanghwa Kim, Seong-Ho Hong, Choon-Keun Bong & Myung-Haing Cho. (2015) Characterization of air freshener emission: the potential health effects. The Journal of Toxicological Sciences 40:5, pages 535-550.
Crossref
Thomas Prates Ong. 2015. Bioactive Essential Oils and Cancer. Bioactive Essential Oils and Cancer 237 250 .
Lawrence J. Marnett, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Robert L. Smith, Timothy B. Adams, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2014) GRASr2 Evaluation of Aliphatic Acyclic and Alicyclic Terpenoid Tertiary Alcohols and Structurally Related Substances Used as Flavoring Ingredients. Journal of Food Science 79:4, pages R428-R441.
Crossref
. 2014. Essential Oil Safety. Essential Oil Safety 677 755 .
Robert Tisserand & Rodney Young. 2014. Essential Oil Safety. Essential Oil Safety 483 647 .
Robert Tisserand & Rodney Young. 2014. Essential Oil Safety. Essential Oil Safety 39 67 .
. (2013) Scientific Opinion on Flavouring Group Evaluation 06, Revision 4 (FGE.06Rev4): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids and esters from chemical groups 1, 3 and 4. EFSA Journal 11:2.
Crossref
Jason Q.D. Goodger & Ian E. Woodrow. 2013. 427 452 .
. (2012) Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species. EFSA Journal 10:11, pages 2966.
Crossref
M.T. Lis-Balchin. 2012. Handbook of Herbs and Spices. Handbook of Herbs and Spices 329 347 .
. (2011) Scientific Opinion on Flavouring Group Evaluation 06, Revision 3 (FGE.06Rev3): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1 and 4. EFSA Journal 9:11.
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 9:5.
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 06, Revision 2 (FGE.06Rev2): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1 and 4. EFSA Journal 9:3.
Crossref
G Zanusso-Junior, J.O Melo, A.L Romero, J.A Dantas, S.M Caparroz-Assef, C.A Bersani-Amado & R.K.N Cuman. (2011) Avaliação da atividade antiinflamatória do coentro (Coriandrum sativum L.) em roedores. Revista Brasileira de Plantas Medicinais 13:1, pages 17-23.
Crossref
M-J R Howes, P J Houghton, D J Barlow, V J Pocock & S R Milligan. (2002) Assessment of estrogenic activity in some common essential oil constituents. Journal of Pharmacy and Pharmacology 54:11, pages 1521-1528.
Crossref
D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes & H. Tagami. (2010) A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients. Food and Chemical Toxicology 48, pages S1-S42.
Crossref
Julnar Usta, Sawsan Kreydiyyeh, Khuzama Knio, Pascale Barnabe, Yolla Bou-Moughlabay & Shawki Dagher. (2009) Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels. Chemico-Biological Interactions 180:1, pages 39-46.
Crossref
. (2009) Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1) : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 7:2, pages 978.
Crossref
D. Mitić-Ćulafić, B. Žegura, B. Nikolić, B. Vuković-Gačić, J. Knežević-Vukčević & M. Filipič. (2009) Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells. Food and Chemical Toxicology 47:1, pages 260-266.
Crossref
George A. Burdock & Ioana G. Carabin. (2009) Safety assessment of coriander (Coriandrum sativum L.) essential oil as a food ingredient. Food and Chemical Toxicology 47:1, pages 22-34.
Crossref
D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes & H. Tagami. (2008) A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients. Food and Chemical Toxicology 46:11, pages S1-S71.
Crossref
A. Lapczynski, S.P. Bhatia, R.J. Foxenberg, C.S. Letizia & A.M. Api. (2008) Fragrance material review on geraniol. Food and Chemical Toxicology 46:11, pages S160-S170.
Crossref
Patrícia Aparecida Batista, Maria Fernanda de Paula Werner, Erica Carvalho Oliveira, Leonel Burgos, Patricia Pereira, Lucimar Filot da Silva Brum & Adair Roberto Soares dos Santos. (2008) Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (−)-linalool in mice. Neuroscience Letters 440:3, pages 299-303.
Crossref
. (2008) Flavouring Group Evaluation 6, Revision 1 (FGE.06Rev1) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:5, pages 616.
Crossref
Christine Carson, Kate Hammer & Jesper Nielsen. 2007. Dermatologic, Cosmeceutic, and Cosmetic Development. Dermatologic, Cosmeceutic, and Cosmetic Development 437 452 .
Mitsuo Miyazawa & Hiromune Takechi. (2019) Biotransformation of Monoterpenoids by the Larvae of Common Cutworm ( Spodoptera litura ) . Natural Product Communications 2:4, pages 1934578X0700200.
Crossref
. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 18 (FGE.18): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aro. EFSA Journal 4:8, pages 331.
Crossref
Raymond A. Kemper, Diane L. Nabb, Shawn A. Gannon, Timothy A. Snow & Anne Marie Api. (2006) COMPARATIVE METABOLISM OF GERANYL NITRILE AND CITRONELLYL NITRILE IN MOUSE, RAT, AND HUMAN HEPATOCYTES. Drug Metabolism and Disposition 34:6, pages 1019-1029.
Crossref
Hiromune TAKECHI & Mitsuo MIYAZAWA. (2006) Biotransformation of Geraniol by the Larvae of Common Cutworm (Spodoptera litura). Journal of Oleo Science 55:3, pages 143-149.
Crossref
. (2004) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 6 (FGE.06): Straight-and branched-chain aliphatic unsatured primary alcohols, aldehydes, carbox. EFSA Journal 2:11, pages 108.
Crossref
M.T. Lis-Balchin. 2004. Handbook of Herbs and Spices. Handbook of Herbs and Spices 162 178 .
M.T. Lis-Balchin. 2004. Handbook of Herbs and Spices. Handbook of Herbs and Spices 179 195 .
D Bickers, P Calow, H Greim, J.M Hanifin, A.E Rogers, J.H Saurat, I.G Sipes, R.L Smith & H Tagami. (2003) A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients. Food and Chemical Toxicology 41:7, pages 919-942.
Crossref
C.S Letizia, J Cocchiara, J Lalko & A.M Api. (2003) Fragrance material review on linalool. Food and Chemical Toxicology 41:7, pages 943-964.
Crossref
David R Bickers, Peter Calow, Helmut A Greim, Jon M Hanifin, Adrianne E Rogers, Jean-Hilaire Saurat, I Glenn Sipes, Robert L Smith & Hachiro Tagami. (2003) The safety assessment of fragrance materials. Regulatory Toxicology and Pharmacology 37:2, pages 218-273.
Crossref
M. De Vincenzi, M. Silano, A. De Vincenzi, F. Maialetti & B. Scazzocchio. (2002) Constituents of aromatic plants: eucalyptol. Fitoterapia 73:3, pages 269-275.
Crossref
Kenneth K Chan. (2001) Quantitation of monoterpenoid compounds with potential medicinal use in biological fluids. Journal of Chromatography A 936:1-2, pages 47-57.
Crossref
Yvette D. Burke, M. Jennifer Stark, Steven L. Roach, Stephanie E. Sen & Pamela L. Crowell. (1997) Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids 32:2, pages 151-156.
Crossref
Anu Harju. (1996) Effect of birch (Betula pendula) bark and food protein level on root voles (Microtus oeconomus): II. detoxification capacity. Journal of Chemical Ecology 22:4, pages 719-728.
Crossref
Marie-Hélène Siess, Anne-Marie Le Bon, Marie-Chantal Canivenc-Lavier, Marie-Josèphe Amiot, Sylvie Sabatier, Serge Y. Aubert & Marc Suschetet. (1996) Flavonoids of Honey and Propolis:  Characterization and Effects on Hepatic Drug-Metabolizing Enzymes and Benzo[ a ]pyrene−DNA Binding in Rats . Journal of Agricultural and Food Chemistry 44:8, pages 2297-2301.
Crossref
Kattigere M. Madyastha & Tarikere L. Gururaja. (2004) Asymmetric reduction of prochiral ketones by cell‐free systems from alcaligenes eutrophus . Journal of Chemical Technology & Biotechnology 59:3, pages 249-255.
Crossref
S.J. Roffey, R. Walker & G.G. Gibson. (1990) Hepatic peroxisomal and microsomal enzyme induction by citral and linalool in rats. Food and Chemical Toxicology 28:6, pages 403-408.
Crossref
Bhagavatula Moorthy, Prema Madyastha & K.Madhava Madyastha. (1989) Hepatotoxicity of pulegone in rats: Its effects on microsomal enzymes, in vivo. Toxicology 55:3, pages 327-337.
Crossref
K. Madhava Madyastha & V. Srivatsan. (1988) Biotransformations of α-terpineol in the rat: Its effects on the liver microsomal cytochrome P-450 system. Bulletin of Environmental Contamination and Toxicology 41:1, pages 17-25.
Crossref
G.M. Jackson, D.E. Hall & R. Walker. (1987) Comparison of the short-term hepatic effects of orally administered citral in long evans hooded and wistar albino rats. Food and Chemical Toxicology 25:7, pages 505-513.
Crossref
K. Madhava Madyastha & Anju Chadha. (1986) Metabolism of 1,8-Cineole in Rat: Its effects on liver and lung microsomal cytochrome P-450 systems. Bulletin of Environmental Contamination and Toxicology 37:1, pages 759-766.
Crossref
Prema Madyastha, B. Moorthy, C.S. Vaidyanathan & K.M. Madyastha. (1985) In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone. Biochemical and Biophysical Research Communications 128:2, pages 921-927.
Crossref

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