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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 8
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Original Article

Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences

Takemi Yoshida Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1–5–8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan
,
Takiko Oguro Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1–5–8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan
&
Yukio Kuroiwa Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1–5–8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan
Pages 957-963 | Received 16 Oct 1986, Published online: 30 Sep 2009

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M. Strolin-Benedetti, G. Brogin, M. Bani, F. Oesch & J. G. Hengstler. (1999) Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate. Xenobiotica 29:11, pages 1171-1180.
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Articles from other publishers (27)

O. A. Buneeva, A. T. Kopylov, V. G. Zgoda & A. E. Medvedev. (2018) The Effect of Deprenyl and Isatin Administration to Mice on the Proteomic Profile of Liver Isatin-Binding Proteins. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 12:4, pages 350-355.
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O.A. Buneeva, A.T. Kopylov, V.G. Zgoda & A.E. Medvedev. (2018) The effect of deprenyl and isatin administration to mice on the proteomic profile of liver isatin-binding proteins. Biomeditsinskaya Khimiya 64:4, pages 354-359.
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Joy Simpson, Colin Ryan, Anita Curley, Jeffrey Mulcaire & John P. Kelly. (2012) Sex differences in baseline and drug-induced behavioural responses in classical behavioural tests. Progress in Neuro-Psychopharmacology and Biological Psychiatry 37:2, pages 227-236.
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K. Magyar, B. Szende, V. Jenei, T. Tábi, M. Pálfi & É. Szökő. (2010) R-Deprenyl: Pharmacological Spectrum of its Activity. Neurochemical Research 35:12, pages 1922-1932.
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Sevil Yasar, Zuzana Justinova, Sun-Hee Lee, Roman Stefanski, Steven R. Goldberg & Gianluigi Tanda. (2006) Metabolic Transformation Plays a Primary Role in the Psychostimulant-Like Discriminative-Stimulus Effects of Selegiline [( R )-(–)-Deprenyl] . Journal of Pharmacology and Experimental Therapeutics 317:1, pages 387-394.
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K. Takahata, S. Shimazu, H. Katsuki, F. Yoneda & A. Akaike. (2005) Effects of selegiline on antioxidant systems in the nigrostriatum in rat. Journal of Neural Transmission 113:2, pages 151-158.
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Jarmo S. Salonen, Leena Nyman, Alan R. Boobis, Robert J. Edwards, Patricia Watts, Brian G. Lake, Roger J. Price, Anthony B. Renwick, Maria-José Gómez-Lechón, José V. Castell, Magnus Ingelman-Sundberg, Mats Hidestrand, Andre Guillouzo, Laurent Corcos, Peter S. Goldfarb, David F.V. Lewis, Päivi Taavitsainen & Olavi Pelkonen. (2003) COMPARATIVE STUDIES ON THE CYTOCHROME P450-ASSOCIATED METABOLISM AND INTERACTION POTENTIAL OF SELEGILINE BETWEEN HUMAN LIVER-DERIVED IN VITRO SYSTEMS. Drug Metabolism and Disposition 31:9, pages 1093-1102.
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KENICHI KITANI, CHIYOKO MINAMI, TAKAKO YAMAMOTO, SETSUKO KANAI, GWEN O. IVY & MARIA-CRISTINA CARRILLO. (2002) Pharmacological Interventions in Aging and Age-associated Disorders. Annals of the New York Academy of Sciences 959:1, pages 295-307.
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Kenichi Kitani, Chiyoko Minami, Ken-ichi Isobe, Kayoko Maehara, Setsuko Kanai, Gwen O. Ivy & Maria-Christina Carrillo. (2002) Why (−)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects. Mechanisms of Ageing and Development 123:8, pages 1087-1100.
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Margherita Strolin Benedetti. (2001) Biotransformation of xenobiotics by amine oxidases. Fundamental & Clinical Pharmacology 15:2, pages 75-84.
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A. Fredriksson, T. Palomo & T. Archer. (2000) Effects of MAO inhibitors upon MPTP mice chronically treated with suprathreshold doses of l -dopa. Behavioral Pharmacology 11:7, pages 571-581.
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Trevor Archer & Anders Fredriksson. (2000) Restoration and putative protection in parkinsonism. Neurotoxicity Research 2:2-3, pages 251-292.
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Massimo Valoti, Fabio Fusi, Maria Frosini, Federica Pessina, Keith F Tipton & Gian P Sgaragli. (2000) Cytochrome P450-dependent n-dealkylation of l-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, β-naphthoflavone and l-deprenyl. European Journal of Pharmacology 391:3, pages 199-206.
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K. Kitani, C. Minami, W. Maruyama, S. Kanai, G. O. Ivy & M.-C. Carrillo. 2000. Advances in Research on Neurodegeneration. Advances in Research on Neurodegeneration 139 156 .
É. Szökõ, H. Kalász & K. Magyar. (1999) Biotransformation of deprenyl enantiomers. European Journal of Drug Metabolism and Pharmacokinetics 24:4, pages 315-319.
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D. Haberle, H. Kalász, I. Hollósi, J. Pucsok, T. Csermely, K. Magyar & E. Tóth-Molnár. (1999) Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD. Chromatographia 50:7-8, pages 415-422.
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Zs Tarjányi, H Kalász, G Szebeni, I Hollósi, M Báthori & S Fürst. (1998) Gas-chromatographic study on the stereoselectivity of deprenyl metabolism. Journal of Pharmaceutical and Biomedical Analysis 17:4-5, pages 725-731.
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József Lengyel, Kálmán Magyar, Ildikó Hollósi, Tibor Bartók, Mária Báthori, Huba Kalász & Susanna Fürst. (1997) Urinary excretion of deprenyl metabolites. Journal of Chromatography A 762:1-2, pages 321-326.
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M.C. Carrillo, K. Kitani, S. Kanai, Y. Sato, G.O. Ivy & K. Miyasaka. (1996) Long term treatment with (−)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain. Life Sciences 59:13, pages 1047-1057.
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A. Fredriksson & T. Archer. (1995) Synergistic interactions between COMT-/MAO-inhibitors and L-Dopa in MPTP-treated mice. Journal of Neural Transmission 102:1, pages 19-34.
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M. Strolin Benedetti, P. Tocchetti, M. Rocchetti, M. Martignoni, P. Marrari, I. Poggesi & P. Dostert. 1995. Current Neurochemical and Pharmacological Aspects of Biogenic Amines - Their Function, Oxidative Deamination and Inhibition. Current Neurochemical and Pharmacological Aspects of Biogenic Amines - Their Function, Oxidative Deamination and Inhibition 123 134 .
KENICHI KITANI, SETSUKO KANAI, MARIA CRISTINA CARRILLO & GWEN O. IVY. (1994) (-)Deprenyl Increases the Life Span as Well as Activities of Superoxide Dismutase and Catalase but Not of Glutathione Peroxidase in Selective Brain Regions in Fischer Rats. Annals of the New York Academy of Sciences 717:1, pages 60-71.
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Douglas L. Gelowitz, J. Steven Richardson, Thomas B. Wishart, Peter H. Yu & Chien-Tsai Lai. (1994) Chronic L-deprenyl or L-amphetamine: Equal cognitive enhancement, unequal MAO inhibition. Pharmacology Biochemistry and Behavior 47:1, pages 41-45.
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E. H. Heinonen, M. I. Anttila & R. A. S. Lammintausta. 1993. Inhibitors of Monoamine Oxidase B. Inhibitors of Monoamine Oxidase B 201 213 .
Chie Okuda, David S. Segal & Ronald Kuczenski. (1992) Deprenyl alters behavior and caudate dopamine through an amphetamine-like action. Pharmacology Biochemistry and Behavior 43:4, pages 1075-1080.
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Deborah W. Robin, Renata Bluhm, Italo Biaggioni & Philip E. Johnston. (1991) Selegiline in the Treatment of Parkinson’s Disease. The American Journal of the Medical Sciences 302:6, pages 392-395.
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Heinonen E H, Myllylä V, Sotaniemi K, Lammintausta R, Salonen J S, Anttila M, Savijärvi M, Kotila M & Rinne U K. (1989) Pharmacokinetics and metabolism of selegiline. Acta Neurologica Scandinavica 80, pages 93-99.
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