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Research Article

Long-term consumption of aspartame and brain antioxidant defense status

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Pages 135-140 | Received 12 Sep 2011, Accepted 09 Jan 2012, Published online: 02 Mar 2012

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Read on this site (3)

Shaimaa Nasr Amin, Sherif Sabry Hassan & Laila Ahmed Rashed. (2018) Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice. Archives of Physiology and Biochemistry 124:4, pages 292-299.
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Arbind Kumar Choudhary & Yeong Yeh Lee. (2018) Neurophysiological symptoms and aspartame: What is the connection?. Nutritional Neuroscience 21:5, pages 306-316.
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Arbind Kumar Choudhary, Lognatahan Sundareswaran & Rathinasamy Sheela Devi. (2016) Effects of aspartame on the evaluation of electrophysiological responses in Wistar albino rats. Journal of Taibah University for Science 10:4, pages 505-512.
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Articles from other publishers (32)

Jakub Trawiński & Robert Skibiński. (2023) Stability of aspartame in the soft drinks: Identification of the novel phototransformation products and their toxicity evaluation. Food Research International 173, pages 113365.
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Haiying Hu, Pianhong Zhang, Junhua Yin, Leilei Wang, Yanyu Lu & Huilan Guo. (2023) The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway. Journal of Physiology and Biochemistry.
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Sharon Parten Fowler, David Gimeno Ruiz de Porras, Michael D. Swartz, Paula Stigler Granados, Lynne Parsons Heilbrun & Raymond F. Palmer. (2023) Daily Early-Life Exposures to Diet Soda and Aspartame Are Associated with Autism in Males: A Case-Control Study. Nutrients 15:17, pages 3772.
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Shurooq Asaad Abdulameer Shaher, Dan Florin Mihailescu & Bogdan Amuzescu. (2023) Aspartame Safety as a Food Sweetener and Related Health Hazards. Nutrients 15:16, pages 3627.
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Susan J. Borghoff, Sarah S. Cohen, Xiaohui Jiang, Isabel A. Lea, William D. Klaren, Grace A. Chappell, Janice K. Britt, Brianna N. Rivera, Neepa Y. Choski & Daniele S. Wikoff. (2023) Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food and Chemical Toxicology 172, pages 113549.
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Mohamed A. Farag, Mona.M. Rezk, Mohamed Hamdi Elashal, Moustafa El-Araby, Shaden A.M. Khalifa & Hesham R. El-Seedi. (2022) An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety. Food Research International 162, pages 111853.
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Bianca-Eugenia Ősz, George Jîtcă, Ruxandra-Emilia Ștefănescu, Amalia Pușcaș, Amelia Tero-Vescan & Camil-Eugen Vari. (2022) Caffeine and Its Antioxidant Properties—It Is All about Dose and Source. International Journal of Molecular Sciences 23:21, pages 13074.
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Kamila Czarnecka, Aleksandra Pilarz, Aleksandra Rogut, Patryk Maj, Joanna Szymańska, Łukasz Olejnik & Paweł Szymański. (2021) Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products. Nutrients 13:6, pages 1957.
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G.J.M. Afonso, J.B. Silva, R.M. Santos, L.M. Rosário, R.M. Quinta-Ferreira & M.E. Quinta-Ferreira. (2020) ROS changes evoked by the natural sweetener Rebaudioside A in a neuronal system. Energy Reports 6, pages 909-914.
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Kai-Jing Yin, Ding-Yuan Xie, Lei Zhao, Gang Fan, Jing-Nan Ren, Lu-Lu Zhang & Si-Yi Pan. (2019) Effects of different sweeteners on behavior and neurotransmitters release in mice. Journal of Food Science and Technology 57:1, pages 113-121.
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Arbind K. Choudhary & Yeong Y. Lee. (2019) Mechanistic Insights into Aspartame-induced Immune Dysregulation. Current Nutrition & Food Science 15:7, pages 653-661.
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Aristidis Tsatsakis, Anca Oana Docea, Carolina Constantin, Daniela Calina, Ovidiu Zlatian, Taxiarchis Konstantinos Nikolouzakis, Polychronis D. Stivaktakis, Alexandra Kalogeraki, Jyrki Liesivuori, George Tzanakakis & Monica Neagu. (2019) Genotoxic, cytotoxic, and cytopathological effects in rats exposed for 18 months to a mixture of 13 chemicals in doses below NOAEL levels. Toxicology Letters 316, pages 154-170.
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G.J.M. Afonso, J.B. Silva, R.M. Santos, L.M. Rosário, R.M. Quinta-Ferreira & M.E. Quinta-Ferreira. (2019) ROS changes evoked by the natural sweetener Rebaudioside A in a neuronal system. Energy Reports 5, pages 1426-1431.
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Sara I. Othman & May Bin- Jumah. (2019) Histopathological Effect of Aspartame on Liver and Kidney of Mice. International Journal of Pharmacology 15:3, pages 336-342.
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Arbind Kumar Choudhary & Yeong Yeh Lee. (2018) The debate over neurotransmitter interaction in aspartame usage. Journal of Clinical Neuroscience 56, pages 7-15.
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Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu & Dilek Taskiran. (2018) Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study. Journal of Biochemical and Molecular Toxicology 32:6, pages e22053.
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Morando Soffritti, Angela Guaragna & Marco Manservigi. 2018. Sweeteners. Sweeteners 311 347 .
Mohamed A. Lebda, Kadry M. Sadek & Yasser S. El-Sayed. (2017) Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels. Metabolic Brain Disease 32:5, pages 1639-1647.
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Arbind Kumar Choudhary & Yeong Lee. (2017) Dysregulated microbiota-gut-brain axis. Nutrition & Food Science 47:5, pages 648-658.
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Arbind Kumar Choudhary & Etheresia Pretorius. (2017) Revisiting the safety of aspartame. Nutrition Reviews 75:9, pages 718-730.
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Isabela Finamor, Salvador Pérez, Caroline A. Bressan, Carlos E. Brenner, Sergio Rius-Pérez, Patricia C. Brittes, Gabriele Cheiran, Maria I. Rocha, Marcelo da Veiga, Juan Sastre & Maria A. Pavanato. (2017) Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice. Redox Biology 11, pages 701-707.
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Morando Soffritti, Angela Guaragna & Marco Manservigi. 2017. Sweeteners. Sweeteners 1 37 .
Adejoke Y. Onaolapo, Olakunle J. Onaolapo & Polycarp U. Nwoha. (2016) Alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers following aspartame ingestion. Journal of Chemical Neuroanatomy 78, pages 42-56.
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Oluwatosin A. Adaramoye & Olubukola O. Akanni. (2016) Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats. Journal of Basic and Clinical Physiology and Pharmacology 27:1, pages 29-37.
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Jonathan M. Borkum. (2016) Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. Headache: The Journal of Head and Face Pain 56:1, pages 12-35.
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Afaf Abbass Sayed Saleh. (2015) Anti-neuroinflammatory and antioxidant effects of N-acetyl cysteine in long-term consumption of artificial sweetener aspartame in the rat cerebral cortex. The Journal of Basic & Applied Zoology 72, pages 73-80.
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M. Abhilash, Mathews V. Varghese, M. V. Sauganth Paul, Manju Alex & R. Harikumaran Nair. (2014) Effect of long-term intake of aspartame on serum biochemical parameters and erythrocyte oxidative stress biomarkers in rats. Comparative Clinical Pathology 24:4, pages 927-933.
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Marko D Prokić, Milica G Paunović, Miloš M Matić, Nataša Z Djordjević, Branka I Ognjanović, Andraš Š Štajn & Zorica S Saičić. (2014) Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats. Journal of Biosciences 39:5, pages 859-866.
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Serkan Yılmaz & Aslı Uçar. (2014) A review of the genotoxic and carcinogenic effects of aspartame: does it safe or not?. Cytotechnology 66:6, pages 875-881.
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Isabela A. Finamor, Giovana M. Ourique, Tanise S. Pês, Etiane M. H. Saccol, Caroline A. Bressan, Taína Scheid, Bernardo Baldisserotto, Susana F. Llesuy, Wânia A. Partata & Maria A. Pavanato. (2014) The Protective Effect of N-Acetylcysteine on Oxidative Stress in the Brain Caused by the Long-Term Intake of Aspartame by Rats. Neurochemical Research 39:9, pages 1681-1690.
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M. Abhilash, Manju Alex, Varghese V. Mathews & R. Harikumaran Nair. (2014) Chronic Effect of Aspartame on Ionic Homeostasis and Monoamine Neurotransmitters in the Rat Brain. International Journal of Toxicology 33:4, pages 332-341.
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. (2013) Output of the public consultation on the draft EFSA scientific opinion on the re‐evaluation of aspartame (E951) as a food additive. EFSA Supporting Publications 10:12.
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