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Research Article

Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes

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Pages 403-411 | Received 14 May 2012, Accepted 05 Oct 2012, Published online: 21 Dec 2012

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Reza Heidari, Fatemeh Ahmadi, Hamid Reza Rahimi, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi & Hossein Niknahad. (2019) Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug and Chemical Toxicology 42:6, pages 615-623.
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Reza Heidari & M. Mehdi OmmatiReza Heidari & M. Mehdi Ommati. 2023. Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases. Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases 108 136 .
丽芹 张. (2022) Advances in the Study of Related Factors of Methimazole-Induced Liver Injury. Advances in Clinical Medicine 12:10, pages 9020-9023.
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Payal Rana, Michael D. Aleo, Xuerong Wen & Stephen Kogut. (2021) Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms. Acta Pharmaceutica Sinica B 11:12, pages 3857-3868.
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Khadijah Mousavi, Ram Kumar Manthari, Asma Najibi, Zhipeng Jia, Mohammad Mehdi Ommati & Reza Heidari. (2021) Mitochondrial dysfunction and oxidative stress are involved in the mechanism of tramadol-induced renal injury. Current Research in Pharmacology and Drug Discovery 2, pages 100049.
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Xuesong Li, Jialin Yang, Shasha Jin, Yu Dai, Yujuan Fan, Xiaofang Fan, Zhigang Li, Jianhua Yang, Wai-Ping Yau, Haishu Lin, Weimin Cai & Xiaoqiang Xiang. (2019) Mechanistic examination of methimazole-induced hepatotoxicity in patients with Grave’s disease: a metabolomic approach. Archives of Toxicology 94:1, pages 231-244.
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Shasha Jin, Xuesong Li, Yujuan Fan, Xiaofang Fan, Yu Dai, Haishu Lin, Weimin Cai, Jialin Yang & Xiaoqiang Xiang. (2019) Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole‐induced liver injury . Basic & Clinical Pharmacology & Toxicology 125:6, pages 508-517.
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Reza Heidari, Mohammad Reza ArabnezhadMohammad Mehdi OmmatiNegar AzarpiraElham GhodsimaneshHossein Niknahad. (2019) Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity. Pharmaceutical Sciences 25:1, pages 1-10.
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Reza Heidari, Leila Mandegani, Vahid Ghanbarinejad, Asma Siavashpour, Mohammad Mehdi Ommati, Negar Azarpira, Asma Najibi & Hossein Niknahad. (2019) Mitochondrial dysfunction as a mechanism involved in the pathogenesis of cirrhosis-associated cholemic nephropathy. Biomedicine & Pharmacotherapy 109, pages 271-280.
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Reza Heidari, Shima Behnamrad, Zahra Khodami, Mohammad Mehdi Ommati, Negar Azarpira & Afsaneh Vazin. (2019) The nephroprotective properties of taurine in colistin-treated mice is mediated through the regulation of mitochondrial function and mitigation of oxidative stress. Biomedicine & Pharmacotherapy 109, pages 103-111.
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Reza Heidari, Asrin Ahmadi, Hamidreza Mohammadi, Mohammad Mehdi Ommati, Negar Azarpira & Hossein Niknahad. (2018) Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance. Biomedicine & Pharmacotherapy 107, pages 834-840.
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Reza Heidari, Faezeh Jafari, Forouzan Khodaei, Babak Shirazi Yeganeh & Hossein Niknahad. (2018) Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. Nephrology 23:4, pages 351-361.
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Qi Wei, Bo Hu, Yuan Xue, David Kibe Mburu, Xian Tao & Jianya Su. (2017) Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 196, pages 54-60.
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Hossein Niknahad, Akram Jamshidzadeh, Reza Heidari, Narges Abdoli, Mohammad Mehdi Ommati, Faezeh Jafari, Mahdi Zarei & Behnam Asadi. (2016) The Postulated Hepatotoxic Metabolite of Methimazole Causes Mitochondrial Dysfunction and Energy Metabolism Disturbances in Liver. Pharmaceutical Sciences 22:4, pages 217-226.
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Hossein Niknahad, Akram Jamshidzadeh, Reza Heidari, Zeynab Hosseini, Keivan Mobini, Forouzan Khodaei, Mohammad Mehdi Ommati, Narges Abdoli, Nahid Keshavarz, Mandana Bazyari & Asma Najibi. (2016) Paradoxical effect of methimazole on liver mitochondria: In vitro and in vivo. Toxicology Letters 259, pages 108-115.
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Ayokunle T. Abegunde, Milli Jain & Ambika Amblee. (2016) Methimazole-Induced Concomitant Agranulocytosis and Cholestasis in a Young Female. AACE Clinical Case Reports 2:3, pages e210-e213.
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Reza Heidari, Nazanin Sadeghi, Negar Azarpira & Hossein Niknahad. (2015) Sulfasalazine-Induced Hepatic Injury in an Ex Vivo Model of Isolated Perfused Rat Liver and the Protective Role of Taurine. Pharmaceutical Sciences 21:4, pages 211-219.
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R.G. Ahmed, M. Abdel-Latif & F. Ahmed. (2015) Protective effects of GM-CSF in experimental neonatal hypothyroidism. International Immunopharmacology 29:2, pages 538-543.
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Reza Heidari, Hossein Niknahad, Akram Jamshidzadeh, Negar Azarpira, Mandana Bazyari & Asma Najibi. (2015) Carbonyl Traps as Potential Protective Agents against Methimazole-Induced Liver Injury. Journal of Biochemical and Molecular Toxicology 29:4, pages 173-181.
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Takeshi Tanaka, Liyun Wang, Masayuki Kimura, Hajime Abe, Sayaka Mizukami, Toshinori Yoshida & Makoto Shibutani. (2015) Developmental Hypothyroidism Abolishes Bilateral Differences in Sonic Hedgehog Gene Control in the Rat Hippocampal Dentate Gyrus. Toxicological Sciences 144:1, pages 128-137.
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Li Wang, Ming-Dan Li, Pei-Pei Cao, Chao-Feng Zhang, Fang Huang, Xiang-Hong Xu, Bao-Lin Liu & Mian Zhang. (2014) Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chemico-Biological Interactions 223, pages 1-9.
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Reza HeidariHossein NiknahadAkram JamshidzadehNarges Abdoli. (2014) Factors affecting drug-induced liver injury: antithyroid drugs as instances. Clinical and Molecular Hepatology 20:3, pages 237.
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Lauren A. Trepanier. (2013) Idiosyncratic Drug Toxicity Affecting the Liver, Skin, and Bone Marrow in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1055-1066.
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Narges Abdoli, Reza Heidari, Yadollah Azarmi & Mohammad Ali Eghbal. (2013) Mechanisms of the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes. Journal of Biochemical and Molecular Toxicology 27:6, pages 287-294.
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