References
- Anoush M, Eghbal MA, Fathiazad F, et al. (2009). The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion. Pak J Biol Sci 12:765–71
- Bergman U, Brittebo, EB. (1999). Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb. Toxicol Appl Pharmacol 155:190–200
- Bergström U, Giovanetti A, Piras E, Brittebo EB. (2003). Methimazole-induced damage in the olfactory mucosa: effects on ultrastructure and glutathione levels. Toxicol Pathol 31:379–87
- Blokhina O, Virolainen E, Fagerstedt KV. (2003). Antioxidants, oxidative damage, and oxygen deprivation stress: a review. Ann Bot 91:179–94
- Brittebo EB. (1995). Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosa. Pharmacol Toxicol 76:76–9
- Damani LA, Nnane IP. (1996). The assessment of flavin-containing monooxygenase activity in intact animals. Drug Metabol Drug Interact 13:1–28
- Decker CJ, Doerge DR, Cashman JR. (1992). Metabolism of benzimidazoline-2-thiones by rat hepatic microsomes and dog liver flavin-containing monooxygenase. Chem Res Toxicol 5:726–33
- Eghbal MA, Pennefather PS, O’Brien PJ. (2004). H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. Toxicology 203:69–76
- Franklyn JA. (2009). Thyroid gland: antithyroid therapy-best choice of drug and dose. Nat Rev Endocrinol 5:592–4
- Galati G, Tafazoli S, Sabzevari O, et al. (2002). Idiosyncratic NSAID drug induced oxidative stress. Chem Biol Interact 142:25–41
- Gallelli L, Staltari O, Palleria C, et al. (2009). Hepatotoxicity induced by methimazole in a previously health patient. Curr Drug Saf 4:204–6
- Genter MB, Deamer NJ, Blake BL, et al. (1995). Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicol Pathol 23:477–86
- Grzywa M, Orlowska-Florek R, Grzywa-Celinska A. (2009). Two cases of serious hepatic injury caused by antithyroid drugs. [Article in Polish]. Endokrynol Pol 60:396–400
- Hengstmann JH, Hohn H. (1985). Pharmacokinetics of methimazole in humans. Klin Wochenschr 63:1212–17
- Jamshidzadeh A, Niknahad H, Kashafi H. (2007). Cytotoxicity of chloroquine in isolated rat hepatocytes. J Appl Toxicol 27:322–6
- Kedderis GL, Rickert DE. (1985). Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism. Role of flavin-containing monooxygenase. Drug Metab Dispos 13:58–61
- Khan S, O’Brien PJ. (1991). 1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes. Biochem Biophys Res Commun 179:436–41
- Kleinman WA, Richie JP, Jr. (2000). Status of glutathione and other thiols and disulfides in human plasma. Biochem Pharmacol 60:19–29
- Kroemer G, Galluzzi L, Brenner C. (2007). Mitochondrial membrane permeabilization in cell death. Physiol Rev 87:99–163
- Lebel CP, Ischiropoulos H, Bondy SC. (1992). Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227–31
- Lee PW, Neal RA. (1978). Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases. Drug Metab Dispos 6:591–600
- Livadas S, Xyrafis X, Economou F, et al. (2010). Liver failure due to antithyroid drugs: report of a case and literature review. Endocrine 38:24–8
- Mansuy D, Dansette PM. (2011). Sulfenic acids as reactive intermediates in xenobiotic metabolism. Arch Biochem Biophys 507:174–85
- Masubuchi Y, Nakayama S, Horie T. (2002). Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology 35:544–51
- Masubuchi Y, Yamada S, Horie T. (2000). Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 292:982–7
- McGirr LG, Jatoe SD, O’Brien PJ. (1990). Myeloperoxidase catalysed cooxidative metabolism of methimazole: oxidation of glutathione and NADH by free radical intermediates. Chem Biol Interact 73:279–95
- Mehta R, Wong L, O’Brien PJ. (2009). Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes. Chem Biol Interact 178:317–23
- Mikhail NE. (2004). Methimazole-induced cholestatic jaundice. South Med J 97:178–82
- Mizutani T, Murakami M, Shirai M, et al. (1999). Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. J Appl Toxicol 19:193–8
- Mizutani T, Yoshida K, Murakami M, et al. (2000). Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies. Chem Res Toxicol 13:170–6
- Muriel P. (2009). Role of free radicals in liver diseases. Hepatol Int 3:526–36
- Poulsen LL, Hyslop RM, Ziegler DM. (1974). S-oxidation of thioureylenes catalyzed by a microsomal flavoprotein mixed-function oxidase. Biochem Pharmacol 23:3431–40
- Qu B, Li QT, Wong KP, et al. (2001). Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes. Free Radic Biol Med 31:659–69
- Riener CK, Kada G, Gruber HJ. (2002). Quick measurement of protein sulfhydryls with Ellman’s reagent and with 4,4′-dithiodipyridine. Anal Bioanal Chem 373:266–76
- Saito C, Zwingmann C, Jaeschke H. (2010). Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology 51:246–54
- Schmidt G, Borsch G, Muller KM, Wegener M. (1986). Methimazole-associated cholestatic liver injury: case report and brief literature review. Hepatogastroenterology 33:244–6
- Shangari N, O’Brien PJ. (2004). The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem Pharmacol 68:1433–42
- Skellern GG, Steer S. (1981). The metabolism of [2-14C]methimazole in the rat. Xenobiotica 11:627–34
- Smith MT, Thor H, Hartizell P, Orrenius S. (1982). The measurement of lipid peroxidation in isolated hepatocytes. Biochem Pharmacol 31:19–26
- Tafazoli S, Spehar DD, O’Brien PJ. (2005). Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab Rev 37:311–25
- Tephly TR, Hibbeln P. (1971). The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450. Biochem Biophys Res Commun 42:589–95
- Tesfa D, Keisu M, Palmblad J. (2009). Idiosyncratic drug-induced agranulocytosis: possible mechanisms and management. Am J Hematol 84:428–34
- Valko M, Leibfritz D, Moncol J, et al. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44–84
- Woeber KA. (2002). Methimazole-induced hepatotoxicity. Endocr Pract 8:222–4
- Wondrak GT, Cervantes-Laurean D, Roberts MJ, et al. (2002). Identification of α-dicarbonyl scavengers for cellular protection against carbonyl stress. Biochem Pharmacol 63:361–73
- Xie F, Zhou X, Genter MB, et al. (2011). The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. Drug Metab Dispos 39:947–51