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Research Article

The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells

Pages 318-327 | Received 21 Nov 2013, Accepted 14 Sep 2014, Published online: 15 Oct 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey & H. Troy Nagle. (2023) Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays. Journal of Toxicology and Environmental Health, Part B 26:6, pages 307-341.
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Marquitta C. Webb, Dana Chong & Sa’eed Bawa. (2021) Consumption patterns of nonnutritive sweeteners among university students at a Caribbean institution. Journal of American College Health 69:7, pages 719-724.
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Mahboubeh Mansourian, Karim Mahnam, Hamid Reza Rajabi, Mahmoud Roushani & Amir Hossein Doustimotlagh. (2020) Exploring the binding mechanism of saccharin and sodium saccharin to promoter of human p53 gene by theoretical and experimental methods. Journal of Biomolecular Structure and Dynamics 38:2, pages 548-564.
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Hanna Bessler & Meir Djaldetti. (2019) The impact of three commercial sweeteners on cytokine expression by mononuclears impelled by colon carcinoma cells. International Journal of Food Sciences and Nutrition 70:8, pages 970-976.
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Colin Berry, David Brusick, Samuel M. Cohen, Jerry F. Hardisty, V. Lee Grotz & Gary M. Williams. (2016) Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale. Nutrition and Cancer 68:8, pages 1247-1261.
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Nashwa Abdelaal, Mohamed A. El-Desouky & Ehab A.M. EL-Shoura. (2023) Genetic study via chromosomal aberration for induced obesity in male albino mice. Gene Reports 33, pages 101851.
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Sofia Pavanello, Angelo Moretto, Carlo La Vecchia & Gianfranco Alicandro. (2023) Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence. Regulatory Toxicology and Pharmacology 139, pages 105369.
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Susan J. Borghoff, Sarah S. Cohen, Xiaohui Jiang, Isabel A. Lea, William D. Klaren, Grace A. Chappell, Janice K. Britt, Brianna N. Rivera, Neepa Y. Choski & Daniele S. Wikoff. (2023) Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food and Chemical Toxicology 172, pages 113549.
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Irene L. Richardson & Steven A. Frese. (2022) Non-nutritive sweeteners and their impacts on the gut microbiome and host physiology. Frontiers in Nutrition 9.
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Marcos Mateo-Fernández, Miguel Josué González-Jiménez, Mercedes Del Río Celestino, Rafel Font, Ángeles Alonso-Moraga & Tania Merinas-Amo. (2022) Toxicological and Nutraceutical Screening Assays of Some Artificial Sweeteners. Processes 10:2, pages 410.
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Sevcan Mamur, Deniz Yüzbaşıoğlu, Sabire Nur Bülbül & Fatma Ünal. (2022) Investigation of cyto-genotoxic effects of a food sweetener Acesulfame potassium. Food and Health 8:4, pages 273-283.
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Alfred Jatho, Jansen Marcos Cambia & Seung-Kwon Myung. (2021) Consumption of artificially sweetened soft drinks and risk of gastrointestinal cancer: a meta-analysis of observational studies. Public Health Nutrition 24:18, pages 6122-6136.
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Yoshinori Hanawa, Masaaki Higashiyama, Chie Kurihara, Rina Tanemoto, Suguru Ito, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Kenichi Inaba, Nao Sugihara, Kazuki Horiuchi, Yoshikiyo Okada, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita & Ryota Hokari. (2021) Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa. Journal of Gastroenterology and Hepatology 36:11, pages 3140-3148.
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Pınar ALTUNKAYNAK & Ece AVULOĞLU YILMAZ. (2021) Food Additives and Genotoxicity. International Journal of Science Letters 3:2, pages 109-120.
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Isabel A. Lea, Grace A. Chappell & Daniele S. Wikoff. (2021) Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 868-869, pages 503389.
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Selda Gezginci-Oktayoglu, Merve Ercin, Serap Sancar, Ertan Celik, Meral Koyuturk, Sema Bolkent & Sehnaz Bolkent. (2021) Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells. Food and Chemical Toxicology 153, pages 112264.
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Un chul Shin, Jeong Su Choi, Yeon Jae Beak, Min woo Lee, Hyung Soo Kim, Dal Woong Choi, Dong Gil Kim & Suhng Wook Kim. (2020) Development of a 68 Ga‐labelled PET tracer for carbonic anhydrase IX‐overexpressed tumors using the artificial sweetener saccharin . Journal of Labelled Compounds and Radiopharmaceuticals 64:3, pages 129-139.
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Juan Carlos Bórquez, Miltha Hidalgo, Juan M. Rodríguez, Alejandra Montaña, Omar Porras, Rodrigo Troncoso & Roberto Bravo-Sagua. (2021) Sucralose Stimulates Mitochondrial Bioenergetics in Caco-2 Cells. Frontiers in Nutrition 7.
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Anca Laura Maghiari, Dorina Coricovac, Iulia Andreea Pinzaru, Ioana Gabriela Macașoi, Iasmina Marcovici, Sebastian Simu, Dan Navolan & Cristina Dehelean. (2020) High Concentrations of Aspartame Induce Pro-Angiogenic Effects in Ovo and Cytotoxic Effects in HT-29 Human Colorectal Carcinoma Cells. Nutrients 12:12, pages 3600.
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Ningning Xie, Xi Huang, Chuyi Yang, Minchen Dai, Lei Cai, Shaoping Deng, Paul J Hardiman & Jue Zhou. (2020) Artificial sweeteners affect the glucose transport rate in the Caco‐2/ NCI‐H716 co‐culture model . Journal of the Science of Food and Agriculture 100:13, pages 4887-4892.
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Azrina Azlan, Hock Eng Khoo, Azliana Abu Bakar Sajak, Noor Atiqah Aizan Abdul Kadir, Barakatun Nisak Mohd Yusof, Zhafarina Mahmood & Sharmin Sultana. (2020) Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars. Food Science & Nutrition 8:9, pages 5048-5062.
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Eleonora Moriconi, Alessandra Feraco, Vincenzo Marzolla, Marco Infante, Mauro Lombardo, Andrea Fabbri & Massimiliano Caprio. (2020) Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners. Frontiers in Endocrinology 11.
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Thaís Pasqualli, Pamella Eduardha Chaves, Lavínia Pereira, Élvio Serpa, Luís Flávio Souza Oliveira & Michel Mansur Machado. (2020) Sucralose causes non‐selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study. Clinical and Experimental Pharmacology and Physiology.
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G.A. Chappell, D.S. Wikoff, C.L. Doepker & S.J. Borghoff. (2020) Lack of potential carcinogenicity for acesulfame potassium – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food and Chemical Toxicology 141, pages 111375.
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G.A. Chappell, S.J. Borghoff, L.L. Pham, C.L. Doepker & D.S. Wikoff. (2020) Lack of potential carcinogenicity for sucralose – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food and Chemical Toxicology 135, pages 110898.
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Susan S. Schiffman & H. Troy Nagle. (2019) Revisited: Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota. Food and Chemical Toxicology 132, pages 110692.
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Alena Gabelova, Katarina Kozics, Lucyna Kapka-Skrzypczak, Marcin Kruszewski & Monika Sramkova. (2019) Nephrotoxicity: Topical issue. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 845, pages 402988.
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Bibin Gnanadhason Anand, Kailash Prasad Prajapati, Kriti Dubey, Naseem Ahamad, Dolat Singh Shekhawat, Pramod Chandra Rath, George Kodimattam Joseph & Karunakar Kar. (2019) Self-Assembly of Artificial Sweetener Aspartame Yields Amyloid-like Cytotoxic Nanostructures. ACS Nano 13:5, pages 6033-6049.
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Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu & Dilek Taskiran. (2018) Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study. Journal of Biochemical and Molecular Toxicology 32:6, pages e22053.
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Shubha N Prakash, Jayakumari Shanthakumari & Anitha Devanath. (2017) Effect of Sucralose on Glucose Uptake in Rat L6 Myotubes. Indian journal of Medical Biochemistry 21:2, pages 162-165.
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Ana Paula  Peron. (2017) Cytogenotoxicity of Shakes Added with Synthetic Micro Ingredients. MOJ Biology and Medicine 1:6.
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Bernadene A. Magnuson, Ashley Roberts & Earle R. Nestmann. (2017) Critical review of the current literature on the safety of sucralose. Food and Chemical Toxicology 106, pages 324-355.
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Fernando Aguilar, Riccardo Crebelli, Alessandro Di Domenico, Birgit Dusemund, Maria Jose Frutos, Pierre Galtier, David Gott, Ursula Gundert‐Remy, Claude Lambré, Jean‐Charles Leblanc, Oliver Lindtner, Peter Moldeus, Pasquale Mosesso, Dominique Parent‐Massin, Agneta Oskarsson, Ivan Stankovic, Ine Waalkens‐Berendsen, Rudolf Antonius Woutersen, Matthew Wright, Maged Younes, Laura Ciccolallo, Paolo Colombo, Federica Lodi & Alicja Mortensen. (2017) Statement on the validity of the conclusions of a mouse carcinogenicity study on sucralose (E 955) performed by the Ramazzini Institute. EFSA Journal 15:5.
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Alves de Oliveira Victor, Maria alves de Oliveira Virleny, Wilma Nogueira de Oliveira Thayse, Nathanna Castro Damasceno Andressa, Emanuel de Oliveira Silva Charles, Regina Arcanjo Medeiros Stella, Moreira Soares Bruno, Cavalcanti Carneiro da Silva Felipe, Pablo Sousa de Aguiar Raí, Torequl Islam Muhammad, Amélia de Carvalho Melo-Cavalcante Ana, Paula Peron Ana & Marcelo de Castro e Sousa Joao. (2017) Evaluation of cytotoxic and mutagenic effects of two artificial sweeteners by using eukaryotic test systems. African Journal of Biotechnology 16:11, pages 547-551.
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Marielly de Sousa BEZERRA, Geiz de Sousa MALAQUIAS, João Marcelo de CASTRO E SOUSA & Ana Paula PERON. (2016) Cytotoxic and genotoxic potential of powdered juices. Food Science and Technology 36:1, pages 49-55.
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