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Experimental Lung Research Volume 37, 2011 - Issue 5
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Research Article

Deletion of serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality

Dongmei WangDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
,
Weimin WangDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
,
Paul DawkinsUniversity of Birmingham, Edgbaston, Birmingham, UK
,
Trevor PatersonRoslin Institute, Edinburgh, Scotland, UK
,
Noor KalshekerUniversity of Nottingham, Nottingham, UK
,
Jean-Michel SallenaveInstitut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
&
A. McGarry HoughtonDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USACorrespondence[email protected]
 show all
Pages 291-300 | Received 05 Oct 2010, Accepted 14 Dec 2010, Published online: 16 May 2011

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Monica Yonashiro Marcelino, Natalia Langenfeld Fuoco, Carolina Arruda de Faria, Rodrigo de Las Heras Kozma, Lais Fernanda Marques & João Tadeu Ribeiro-Paes. (2014) Animal models in chronic obstructive pulmonary disease—an overview. Experimental Lung Research 40:6, pages 259-271.
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Shuling Guo, Sheri L Booten, Andrew Watt, Luis Alvarado, Susan M Freier, Jeffery H Teckman, Michael L McCaleb & Brett P Monia. (2014) Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease. Rare Diseases 2:1.
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Articles from other publishers (21)

Xueguang Zhang, Rui Zheng, Chen Liang, Haotian LiuXiaozhen Zhang, Yongyi MaMohan LiuWei ZhangYang Yang, Man LiuChuan Jiang, Qingjia RenYan Wang, Suren Chen, Yihong Yang & Ying Shen. (2022) Loss-of-function mutations in CEP78 cause male infertility in humans and mice . Science Advances 8:40.
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Steven P. Grover & Nigel Mackman. (2022) Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis. Frontiers in Cardiovascular Medicine 9.
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Aneela Nomura & Ichiro Taniuchi. (2021) Is α1-Antitrypsin Important for Murine Thymocyte Development?. Trends in Immunology 42:3, pages 178-180.
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Rashika Joshi, Mohit Ojha, Jana Lewis, Qiang Fan, Brett Monia, Shuling Guo & Brian M. Varisco. (2019) Sex-specific differences in emphysema using a murine antisense oligonucleotide model of α-1 antitrypsin deficiency. American Journal of Physiology-Lung Cellular and Molecular Physiology 316:6, pages L1165-L1173.
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Reto Eggenschwiler, Atanas Patronov, Jan Hegermann, Mariane Fráguas-Eggenschwiler, Guangming Wu, Leon Cortnumme, Matthias Ochs, Iris Antes & Tobias Cantz. (2019) A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants. Scientific Reports 9:1.
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Rashika Joshi, Andrea Heinz, Qiang Fan, Shuling Guo, Brett Monia, Christian E. H. Schmelzer, Anthony S. Weiss, Matthew Batie, Harikrishnan Parameshwaran & Brian M. Varisco. (2018) Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin–Deficient Emphysema . American Journal of Respiratory Cell and Molecular Biology 59:2, pages 167-178.
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Karen Jülicher, Annabell Wähner, Kerstin Haase, Karen W. Barbour, Franklin G. Berger, Lutz Wiehlmann, Colin Davenport, Karin Schuster-Gossler, Jörn Stitz, Tobias Cantz & Reto Eggenschwiler. (2018) Functional characterization of the mouse Serpina1 paralog DOM-7. Biological Chemistry 399:6, pages 577-582.
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Florie Borel, Huaming SunMarina ZiegerAndrew CoxBrynn CardozoWeiying LiGabriella OliveiraAiriel DavisAlisha GruntmanTerence R. FlotteMichael H. Brodsky, Andrew M. HoffmanMai K. ElmallahChristian Mueller. (2018) Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema . Proceedings of the National Academy of Sciences 115:11, pages 2788-2793.
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Scott M. Gordon & Alan T. Remaley. (2017) High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis. Atherosclerosis 259, pages 104-113.
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Dolan SondhiKatie M. StilesBishnu P. DeRonald G. Crystal. (2017) Genetic Modification of the Lung Directed Toward Treatment of Human Disease. Human Gene Therapy 28:1, pages 3-84.
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Samuel Alam & Ravi Mahadeva. 2017. Alpha-1-antitrypsin Deficiency. Alpha-1-antitrypsin Deficiency 179 195 .
Chi F. Hung & William A. Altemeier. 2017. Acute Lung Injury and Repair. Acute Lung Injury and Repair 25 38 .
Kevin Ni, Karina A. Serban, Chanan Batra & Irina Petrache. (2016) Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema. Annals of the American Thoracic Society 13:Supplement_4, pages S311-S316.
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Mayur V. Bakshi, Omid Azimzadeh, Juliane Merl-Pham, Tine Verreet, Stefanie M. Hauck, Mohammed A. Benotmane, Michael J. Atkinson & Soile Tapio. (2016) In-Utero Low-Dose Irradiation Leads to Persistent Alterations in the Mouse Heart Proteome. PLOS ONE 11:6, pages e0156952.
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Stefanie J. Willmann, Nikola S. Mueller, Silvia Engert, Michael Sterr, Ingo Burtscher, Aurelia Raducanu, Martin Irmler, Johannes Beckers, Steffen Sass, Fabian J. Theis & Heiko Lickert. (2016) The global gene expression profile of the secondary transition during pancreatic development. Mechanisms of Development 139, pages 51-64.
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Julia G Payne, Ayuko Takahashi, Michelle I Higgins, Emily L Porter, Bela Suki, Alejandro Balazs & Andrew A Wilson. (2016) Multilineage transduction of resident lung cells in vivo by AAV2/8 for α1-antitrypsin gene therapy. Molecular Therapy - Methods & Clinical Development 3, pages 16042.
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Charaf Benarafa. 2015. The Serpin Family. The Serpin Family 59 76 .
Tiziana P. Cremona, Stefan A. TschanzChristophe von Garnier & Charaf Benarafa. (2013) SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice. American Journal of Physiology-Lung Cellular and Molecular Physiology 305:12, pages L981-L989.
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Eli C Lewis. (2012) Expanding the Clinical Indications for α1-Antitrypsin Therapy. Molecular Medicine 18:6, pages 957-970.
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Gillian L. McNab, Timothy R. Dafforn, Alice Wood, Elizabeth Sapey & Robert A. Stockley. (2011) A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency. Mammalian Genome 23:3-4, pages 241-249.
Crossref
Rebecca M. Baron, Alexander J. S. Choi, Caroline A. Owen & Augustine M. K. Choi. (2012) Genetically manipulated mouse models of lung disease: potential and pitfalls. American Journal of Physiology-Lung Cellular and Molecular Physiology 302:6, pages L485-L497.
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