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Review Articles

Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy

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Pages 399-408 | Received 01 Mar 2013, Accepted 18 May 2013, Published online: 11 Jul 2013

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Lasse Neukirch, Cyrielle Fougeroux, Anne-Marie Carola Andersson & Peter Johannes Holst. (2020) The potential of adenoviral vaccine vectors with altered antigen presentation capabilities. Expert Review of Vaccines 19:1, pages 25-41.
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Min Luo, Lei Shi, Fuhe Zhang, Feifan Zhou, Linglin Zhang, Bo Wang, Peiru Wang, Yunfeng Zhang, Haiyan Zhang, Degang Yang, Guolong Zhang, Wei R. Chen & Xiuli Wang. (2018) Laser immunotherapy for cutaneous squamous cell carcinoma with optimal thermal effects to enhance tumour immunogenicity. International Journal of Hyperthermia 34:8, pages 1337-1350.
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Irina V. Guzhova & Boris A. Margulis. (2016) HSP70-based anti-cancer immunotherapy. Human Vaccines & Immunotherapeutics 12:10, pages 2529-2535.
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Nathalie van den Tempel, Michael R. Horsman & Roland Kanaar. (2016) Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms. International Journal of Hyperthermia 32:4, pages 446-454.
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Nina Werthmöller, Benjamin Frey, Michael Rückert, Michael Lotter, Rainer Fietkau & Udo S. Gaipl. (2016) Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo. International Journal of Hyperthermia 32:1, pages 23-30.
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Mark W. Dewhirst, Chen-Ting Lee & Kathleen A. Ashcraft. (2016) The future of biology in driving the field of hyperthermia. International Journal of Hyperthermia 32:1, pages 4-13.
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Mayra L. Sottile, Antonella D. Losinno, Mariel A. Fanelli, F. Darío Cuello-Carrión, M. Magdalena Montt-Guevara, Laura M. Vargas-Roig & Silvina B. Nadin. (2015) Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines. International Journal of Hyperthermia 31:5, pages 464-475.
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Maxim A Shevtsov, Alexander V Kim, Konstantin A Samochernych, Irina V Romanova, Boris A Margulis, Irina V Guzhova, Igor V Yakovenko, Alexander M Ischenko & William A Khachatryan. (2014) Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children. OncoTargets and Therapy 7, pages 1071-1081.
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Jason W.-L. Eng, Chelsey B. Reed, Kathleen M. Kokolus & Elizabeth A. Repasky. (2014) Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia. International Journal of Hyperthermia 30:8, pages 540-546.
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Elizabeth A. Repasky. (2013) Progress in development of biomedical applications of heat shock proteins and thermal stress. International Journal of Hyperthermia 29:5, pages 359-361.
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Articles from other publishers (36)

Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Paola Perez, Youngmi Ji, Benjamin N. French, Thomas J.F. Pranzatelli, Drew G. Michael, Hongen Yin, Susan S. Chow, Maryam Khalaj, Sandra A. Afione, Changyu Zheng, Fabiola Reis Oliveira, Ana Carolina F. Motta, Alfredo Ribeiro-Silva, Eduardo M. Rocha, Cuong Q. Nguyen, Masayuki Noguchi, Tatsuya Atsumi, Blake M. Warner & John A. Chiorini. (2022) Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren’s syndrome. Journal of Clinical Investigation 132:6.
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Yuanyuan Cao, Quanzhong Ren, Rongzhang Hao & Zhiwei Sun. (2022) Innovative strategies to boost photothermal therapy at mild temperature mediated by functional nanomaterials. Materials & Design 214, pages 110391.
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Pietro Poggio, Matteo Sorge, Laura Seclì & Mara Brancaccio. (2021) Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression. Frontiers in Cell and Developmental Biology 9.
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Tatiana N. Sharapova, Elena A. Romanova, Olga K. Ivanova, Denis V. Yashin & Lidia P. Sashchenko. (2021) Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells. International Journal of Molecular Sciences 22:13, pages 6889.
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Henryk M. Kozłowski, Małgorzata Pawlikowska, Justyna Sobocińska, Tomasz Jędrzejewski, Artur Dzialuk & Sylwia Wrotek. (2021) Distinct Modulatory Effects of Fever-Range Hyperthermia on the Response of Breast Cancer Cells and Macrophages to Mistletoe (Viscum album L.) Extract. Pharmaceuticals 14:6, pages 551.
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Luman Wang, Ying Fu, Baichao Yu, Xuechao Jiang, Hongchun Liu, Jun Liu, Bingbing Zha & Yiwei Chu. (2021) HSP70, a Novel Regulatory Molecule in B Cell-Mediated Suppression of Autoimmune Diseases. Journal of Molecular Biology 433:1, pages 166634.
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Chieh-Ting Fang, Hsiao-Hui Kuo, Shao-Chun Hsu & Ling-Huei Yih. (2020) HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors. Cell Death & Disease 11:8.
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Srihatach Ngarmukos, Shaun Scaramuzza, Nipaporn Theerawattanapong, Aree Tanavalee & Sittisak Honsawek. (2018) Circulating and Synovial Fluid Heat Shock Protein 70 Are Correlated with Severity in Knee Osteoarthritis. CARTILAGE 11:3, pages 323-328.
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Zarema Albakova, Grigoriy A. Armeev, Leonid M. Kanevskiy, Elena I. Kovalenko & Alexander M. Sapozhnikov. (2020) HSP70 Multi-Functionality in Cancer. Cells 9:3, pages 587.
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Elena A. Romanova, Tatiana N. Sharapova, Georgii B. Telegin, Alexei N. Minakov, Alexander S. Chernov, Olga K. Ivanova, Maxim L. Bychkov, Lidia P. Sashchenko & Denis V. Yashin. (2020) A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death. Cells 9:2, pages 488.
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Balázs Besztercei, Tamás Vancsik, Anett Benedek, Enikő Major, Mbuotidem J. Thomas, Csaba A. Schvarcz, Tibor Krenács, Zoltán Benyó & Andrea Balogh. (2019) Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects. International Journal of Molecular Sciences 20:16, pages 4019.
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Luis H Solis, Yoshira Ayala, Susana Portillo, Armando Varela-Ramirez, Renato Aguilera & Thomas Boland. (2019) Thermal inkjet bioprinting triggers the activation of the VEGF pathway in human microvascular endothelial cells in vitro . Biofabrication 11:4, pages 045005.
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Yao Lei, Furong Zhao, Junjun Shao, Yangfan Li, Shifang Li, Huiyun Chang & Yongguang Zhang. (2019) Application of built-in adjuvants for epitope-based vaccines. PeerJ 6, pages e6185.
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Maxim Shevtsov & Gabriele Multhoff. 2019. Chaperokine Activity of Heat Shock Proteins. Chaperokine Activity of Heat Shock Proteins 211 243 .
László Gráf, Lóránd Barabás, Balázs Madaras, Nóra Garam, Éva Maláti, Laura Horváth, Zoltán Prohászka, Zsolt Horváth & Judit Kocsis. (2018) High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort. Cancer Biomarkers 23:4, pages 539-547.
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Ye Tian, Huanli Xu, Ammad Ahmad Farooq, Baozeng Nie, Xiaoliang Chen, Shuonan Su, Ru Yuan, Gan Qiao, Cong Li, Xiao Li, Xiaohui Liu & Xiukun Lin. (2018) Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells. Phytotherapy Research 32:7, pages 1320-1331.
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Vladimir F. Lazarev, Dmitry V. Sverchinsky, Elena R. Mikhaylova, Pavel I. Semenyuk, Elena Y. Komarova, Sergey A. Niskanen, Alina D. Nikotina, Anton V. Burakov, Viktor G. Kartsev, Irina V. Guzhova & Boris A. Margulis. (2018) Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models. Cell Death & Disease 9:2.
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Marta Wozniak, Siddarth Agrawal, Zdzislaw Wozniak, Witold A. Trzeciakowski, Piotr Ziolkowski & Kamil Jurczyszyn. (2018) The effect of in vitro photodynamic therapy on increase of osteopontin and heat shock protein 70 expression in squamous cell and colon carcinoma. IEEE Journal of Selected Topics in Quantum Electronics, pages 1-1.
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Saini Setua, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan, Anna Danilushkina, Hojae Lee, Insung S. Choi, Rawil Fakhrullin, Lorenzo Degli Esposti, Anna Tampieri, Michele Iafisco, Maxim Shevtsov & Gabriele Multhoff. 2018. Nanotechnologies in Preventive and Regenerative Medicine. Nanotechnologies in Preventive and Regenerative Medicine 399 511 .
Y. Rajesh, Angana Biswas & Mahitosh Mandal. (2017) Glioma progression through the prism of heat shock protein mediated extracellular matrix remodeling and epithelial to mesenchymal transition. Experimental Cell Research 359:2, pages 299-311.
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Gloria Lopez-Romero, Thania Garzon, Raul Rascon, Alejandra Valdez, Jael Quintero, Aldo A. Arvizu-Flores, Adriana Garibay-Escobar, Lucila Rascon, Humberto Astiazarán-García & Carlos Velazquez. (2017) Characterization of BIP protein of G. lamblia as a potential immunogen in a mouse infection model. Immunobiology 222:8-9, pages 884-891.
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Mateja Kralj Juric, Maxim Shevtsov, Petra Mozes, Justyna Ogonek, Rachel E. Crossland, Anne M. Dickinson, Hildegard T. Greinix, Ernst Holler, Eva M. Weissinger & Gabriele Multhoff. (2017) B-Cell-Based and Soluble Biomarkers in Body Liquids for Predicting Acute/Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Frontiers in Immunology 7.
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Shouju Wang, Ying Tian, Wei Tian, Jing Sun, Shuang Zhao, Ying Liu, Chunyan Wang, Yuxia Tang, Xingqun Ma, Zhaogang Teng & Guangming Lu. (2016) Selectively Sensitizing Malignant Cells to Photothermal Therapy Using a CD44-Targeting Heat Shock Protein 72 Depletion Nanosystem. ACS Nano 10:9, pages 8578-8590.
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Maxim Shevtsov & Gabriele Multhoff. (2016) Heat Shock Protein–Peptide and HSP-Based Immunotherapies for the Treatment of Cancer. Frontiers in Immunology 7.
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Darya A. Meshalkina, Maxim A. Shevtsov, Anatoliy V. Dobrodumov, Elena Y. Komarova, Irina V. Voronkina, Vladimir F. Lazarev, Boris A. Margulis & Irina V. Guzhova. (2016) Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells. Oncotarget 7:16, pages 22050-22063.
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Vladimir F. Lazarev, Alina D. Nikotina, Elena R. Mikhaylova, Evgeny Nudler, Sergey G. Polonik, Irina V. Guzhova & Boris A. Margulis. (2016) Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH. Biochemical and Biophysical Research Communications 470:3, pages 766-771.
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Maxim A. Shevtsov, Boris P. Nikolaev, Liudmila Y. Yakovleva, Marina A. Parr, Yaroslav Y. Marchenko, Igor Eliseev, Anna Yudenko, Anatolii V. Dobrodumov, Olga Zlobina, Alexander Zhakhov, Alexander M. Ischenko, Emil Pitkin & Gabriele Multhoff. (2015) 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma. Journal of Controlled Release 220, pages 329-340.
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Gabriele Multhoff, Alan G. Pockley, Thomas E. Schmid & Daniela Schilling. (2015) The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation. Cancer Letters 368:2, pages 179-184.
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Elena Y. Komarova, Darya A. Meshalkina, Nikolay D. Aksenov, Ivan M. Pchelin, Elena Martynova, Boris A. Margulis & Irina V. Guzhova. (2014) The discovery of Hsp70 domain with cell-penetrating activity. Cell Stress and Chaperones 20:2, pages 343-354.
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Apichat Asavamongkokul, Pojchong Chotiyarnwonga, Pojchong Chotiyarnwonga, Nednapis Tirawanchai & Saranatra Waikakul. (2015) Heat Shock Protein 70 Expression in Giant Cell Tumor of Bone and Its Clinical Application. Surgical Science 06:02, pages 26-34.
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Maxim A. Shevtsov, Boris P. Nikolaev, Vyacheslav A. Ryzhov, Ludmila Y. Yakovleva, Yaroslav Y. Marchenko, Marina A. Parr, Valerij I. Rolich, Anastasiya L. Mikhrina, Anatolii V. Dobrodumov, Emil Pitkin & Gabriele Multhoff. (2015) Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION–cmHsp70.1). Nanoscale 7:48, pages 20652-20664.
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Mark W. Dewhirst, John Abraham & Benjamin Viglianti. 2015. 397 421 .
Maxim A. Shevtsov, Elena Y. Komarova, Darya A. Meshalkina, Natalia V. Bychkova, Nikolai D. Aksenov, Sergey V. Abkin, Boris A. Margulis & Irina V. Guzhova. (2014) Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity. Oncotarget 5:10, pages 3101-3114.
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Lin Gong, Chen Hui Wang, Yi Jiao Huang, Feng Liu, Teng Li, Jiang Dai, Ai ling Li, Tao Zhou, Qing Xia & Liang Chen. (2014) CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity. Biochemical and Biophysical Research Communications 447:1, pages 64-69.
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Tomohiro ITO, Kazunori GOTO, Jun TAKANARI, Takehito MIURA, Koji WAKAME, Hiroshi NISHIOKA, Aiko TANAKA & Jun NISHIHIRA. (2014) Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men. Journal of Nutritional Science and Vitaminology 60:4, pages 283-290.
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Xiaowen Wang, Qixiao Jiang, Wencheng Wang, Li Su, Yantao Han & Chunbo Wang. (2014) Molecular mechanism of polypeptides from Chlamys farreri (PCF)’s anti-apoptotic effect in UVA-exposed HaCaT cells involves HSF1/HSP70, JNK, XO, iNOS and NO/ROS. Journal of Photochemistry and Photobiology B: Biology 130, pages 47-56.
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