400
Views
76
CrossRef citations to date
0
Altmetric
Original Article

Pharmacological Modification of the Epithelial Permeability by Benzalkonium Chloride in UVA/Riboflavin Corneal Collagen Cross-Linking

, , , , &
Pages 715-721 | Received 05 Nov 2009, Accepted 23 Mar 2010, Published online: 30 Jul 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Roy S Rubinfeld, Glenwood G Gum, Jonathan H Talamo & Edward C Parsons. (2021) The Effect of Sodium Iodide on Stromal Loading, Distribution and Degradation of Riboflavin in a Rabbit Model of Transepithelial Corneal Crosslinking. Clinical Ophthalmology 15, pages 1985-1994.
Read now
Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed & Abdelmonem M Hamed. (2017) Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up. Clinical Ophthalmology 11, pages 767-771.
Read now
Majid Moshirfar, Mark D Mifflin, Michael V McCaughey & Adam J Gess. (2014) Prospective, randomized, contralateral eye comparison of tetracaine and proparacaine for pain control in laser in situ keratomileusis and photorefractive keratectomy. Clinical Ophthalmology 8, pages 1213-1219.
Read now
Majed Alkharashi, Ziyad Alharbi & Yassine J Daoud. (2014) Corneal cross-linking. Expert Review of Ophthalmology 9:4, pages 305-313.
Read now
Clara C Chan & Victoria Squissato. (2013) Keratoconus and crosslinking: pharmacokinetic considerations. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1613-1624.
Read now
Frederik Raiskup, Roberto Pinelli & Eberhard Spoerl. (2012) Riboflavin Osmolar Modification for Transepithelial Corneal Cross-Linking. Current Eye Research 37:3, pages 234-238.
Read now
Heyjin C Park, Ravi Champakalakshmi, Pradeep P Panengad, Michael Raghunath & Jodhbir S Mehta. (2011) Tissue adhesives in ocular surgery. Expert Review of Ophthalmology 6:6, pages 631-655.
Read now

Articles from other publishers (69)

Yutaka Yamagata & Takeshi Ide. (2023) A Novel Riboflavin Formulation for Corneal Delivery Without Damaging Epithelial Cells. Translational Vision Science & Technology 12:11, pages 10.
Crossref
K.C. Iselin, L.M. Bachmann, M.A. Thiel, F. Sanak, P.B. Baenninger & C. Kaufmann. (2023) A fluorophotometric comparison of anterior chamber riboflavin delivery via corneal application and fornix instillation. Archivos de la Sociedad Española de Oftalmología (English Edition) 98:11, pages 627-632.
Crossref
K.C. Iselin, L.M. Bachmann, M.A. Thiel, F. Sanak, P.B. Baenninger & C. Kaufmann. (2023) Comparación fluorofotométrica de la administración de riboflavina en la cámara anterior mediante aplicación corneal e instilación en el fórnix. Archivos de la Sociedad Española de Oftalmología 98:11, pages 627-632.
Crossref
Ayşe Tüfekçi Balıkçı & Hafize Gökben Ulutaş. (2023) Comparison of topographic outcomes between HPMC based and vitamin E TPGS based riboflavin solutions after corneal cross-linking. European Journal of Ophthalmology, pages 112067212311763.
Crossref
Mei Yang, Wenjin Xu, Zhongxing Chen, Ming Chen, Xiaoyu Zhang, Huanhuan He, Yushan Wu, Xueyang Chen, Tianjiao Zhang, Mengdi Yan, Jieyi Bai, Colm McAlinden, Keith M. Meek, Jinjin Yu, Shengnan Ding, Rongrong Gao, Jinhai Huang & Xingtao Zhou. (2022) Engineering Hibiscus‐Like Riboflavin/ZIF‐8 Microsphere Composites to Enhance Transepithelial Corneal Cross‐Linking. Advanced Materials 34:21, pages 2109865.
Crossref
Janine Lenk, Robert Herber, Frederik Raiskup, Lutz E. Pillunat & Eberhard Spörl. (2021) Grundlagen des kornealen CrosslinkingPrinciples of corneal cross-linking. Der Ophthalmologe 119:4, pages 332-341.
Crossref
Davide Borroni, Chiara Bonzano, Rozaliya Hristova, José María Sánchez González, Flavia Pennisi, Aurelio Rocha-Bogas & Carlos Rocha de Lossada. (2021) A New Surgical Technique to Deliver Riboflavin Beneath Corneal Epithelium: The Corneal Cross-Linking Epi-Pocket. Asia-Pacific Journal of Ophthalmology 10:5, pages 495-498.
Crossref
Emre Aydın & Mehmet Gökhan Aslan. (2021) The efficiency and safety of oxygen-supplemented accelerated transepithelial corneal cross-linking. International Ophthalmology 41:9, pages 2993-3005.
Crossref
Stefan J. Lang, Philip Maier & Thomas Reinhard. (2021) Crosslinking und Keratokonus. Klinische Monatsblätter für Augenheilkunde 238:06, pages 733-747.
Crossref
Eren Aytekin & Sibel Bozdağ Pehlivan. (2021) Corneal cross-linking approaches on keratoconus treatment. Journal of Drug Delivery Science and Technology 63, pages 102524.
Crossref
Evan K. Dackowski, Juan Batlle Logroño, Cristina Rivera, Najwa Taylor, Patrick D. Lopath & Roy S. Chuck. (2021) Transepithelial Corneal Crosslinking Using a Novel Ultraviolet Light-Emitting Contact Lens Device: A Pilot Study. Translational Vision Science & Technology 10:5, pages 5.
Crossref
Stefan J. Lang, Philip Maier & Thomas Reinhard. (2021) Crosslinking und Keratokonus. Augenheilkunde up2date 11:02, pages 111-125.
Crossref
S. Saad, R. Saad, L. Jouve, S. Kallel, L. Trinh, I. Goemaere, V. Borderie & N. Bouheraoua. (2020) Corneal crosslinking in keratoconus management. Journal Français d'Ophtalmologie 43:10, pages 1078-1095.
Crossref
Eren Aytekin, Naile Öztürk, İmran Vural, H. Kerem Polat, Hasan Basri Çakmak, Sema Çalış & Sibel Bozdağ Pehlivan. (2020) Design of ocular drug delivery platforms and in vitro - in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment. Journal of Controlled Release 324, pages 238-249.
Crossref
Emilio Pedrotti, Chiara Chierego, Erika Bonacci, Alessandra De Gregorio, Arianna De Rossi, Andrea Zuliani, Adriano Fasolo & Giorgio Marchini. (2020) New treatments for keratoconus. International Ophthalmology 40:7, pages 1619-1623.
Crossref
Sarah W. DeParis, Angela Y. Zhu, Shoumyo Majumdar, Jing Tian, Jennifer Elisseeff, Albert S. Jun & Nicholas R. Mahoney. (2019) Effects of collagen crosslinking on porcine and human tarsal plate. BMC Ophthalmology 19:1.
Crossref
Roy S. Rubinfeld, Ciro Caruso & Carmine Ostacolo. (2019) Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions. Cornea 38:6, pages 780-790.
Crossref
David P. S. O’Brart. 2019. Controversies in the Management of Keratoconus. Controversies in the Management of Keratoconus 53 74 .
Leopoldo Spadea, Lucia Di Genova & Emanuele Tonti. (2018) Corneal stromal demarcation line after 4 protocols of corneal crosslinking in keratoconus determined with anterior segment optical coherence tomography. Journal of Cataract and Refractive Surgery 44:5, pages 596-602.
Crossref
Peter S. Hersh, Michael J. Lai, John D. Gelles & Sebastian P. Lesniak. (2018) Transepithelial corneal crosslinking for keratoconus. Journal of Cataract and Refractive Surgery 44:3, pages 313-322.
Crossref
Konstantinos D. Andreanos, Kate Hashemi, Myrsini Petrelli, Konstantinos Droutsas, Ilias Georgalas & George D. Kymionis. (2017) Keratoconus Treatment Algorithm. Ophthalmology and Therapy 6:2, pages 245-262.
Crossref
David P.S. O’Brart. (2016) Corneal Collagen Crosslinking for Corneal Ectasias: A Review. European Journal of Ophthalmology 27:3, pages 253-269.
Crossref
Giuseppe Lombardo, Norberto Liborio Micali, Valentina Villari, Nancy Leone, Sebastiano Serrao, Dario Rusciano & Marco Lombardo. (2017) Assessment of stromal riboflavin concentration–depth profile in nanotechnology-based transepithelial corneal crosslinking. Journal of Cataract and Refractive Surgery 43:5, pages 680-686.
Crossref
Friederike Schaub, Philip Enders, Björn O. Bachmann, Ludwig M. Heindl & Claus Cursiefen. (2017) Effect of corneal collagen crosslinking on subsequent deep anterior lamellar keratoplasty (DALK) in keratoconus. Graefe's Archive for Clinical and Experimental Ophthalmology 255:4, pages 811-816.
Crossref
Andrea Cruzat, Anita N. Shukla, Samer N. Arafat, Saleh Alageel, Clara Colon, James Chodosh & Joseph B. Ciolino. (2017) Ex Vivo Study of Transepithelial Corneal Cross-linking. Journal of Refractive Surgery 33:3, pages 171-177.
Crossref
GitanshaShreyas Sachdev & Mahipal Sachdev. (2017) Recent advances in corneal collagen cross-linking. Indian Journal of Ophthalmology 65:9, pages 787.
Crossref
Cosimo Mazzotta, Frederik Raiskup, Stefano Baiocchi, Giuliano Scarcelli, Marc D. Friedman & Claudio TraversiCosimo Mazzotta, Frederik Raiskup, Stefano Baiocchi, Giuliano Scarcelli, Marc D. Friedman & Claudio Traversi. 2017. Management of Early Progressive Corneal Ectasia. Management of Early Progressive Corneal Ectasia 33 62 .
David O’Brart. 2017. Keratoconus. Keratoconus 219 238 .
Rebecca McQuaid, Michael Mrochen, Brian Vohnsen, Eberhard Spoerl, Sabine Kling & Cynthia J. Roberts. 2017. Corneal Collagen Cross Linking. Corneal Collagen Cross Linking 63 86 .
Marina Hovakimyan, Oliver Stachs, Olmiere Céline & Rudolf F. Guthoff. (2016) Matrix-Based Regenerating Agent for Corneal Wound Healing After Collagen Cross-Linking. Cornea 35:12, pages 1638-1643.
Crossref
Nada H. Aldahlawi, Sally Hayes, David P.S. O'Brart, Naomi D. O'Brart & Keith M. Meek. (2016) An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols. Experimental Eye Research 153, pages 141-151.
Crossref
Xiaoyu Zhang, Ling Sun, Yingjun Chen, Meiyan Li, Mi Tian & Xingtao Zhou. (2016) One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45 mW/cm2) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients. Scientific Reports 6:1.
Crossref
Nicolin S. Gallhoefer, Bernhard M. Spiess, Franco Guscetti, Monika Hilbe, Sonja Hartnack, Farhad Hafezi & Simon A. Pot. (2015) Penetration depth of corneal cross‐linking with riboflavin and UV ‐A ( CXL ) in horses and rabbits . Veterinary Ophthalmology 19:4, pages 275-284.
Crossref
Rebecca McQuaid, Michael Mrochen & Brian Vohnsen. (2016) Rate of riboflavin diffusion from intrastromal channels before corneal crosslinking. Journal of Cataract and Refractive Surgery 42:3, pages 462-468.
Crossref
Ciro Caruso, Carmine Ostacolo, Robert L. Epstein, Gaetano Barbaro, Salvatore Troisi & Decio Capobianco. (2016) Transepithelial Corneal Cross-Linking With Vitamin E-Enhanced Riboflavin Solution and Abbreviated, Low-Dose UV-A. Cornea 35:2, pages 145-150.
Crossref
Kimberly M. Hsu & Joel Sugar. 2017. Pharmacologic Therapy of Ocular Disease. Pharmacologic Therapy of Ocular Disease 137 161 .
J. Bradley Randleman, Sumitra S. Khandelwal & Farhad Hafezi. (2015) Corneal cross-linking. Survey of Ophthalmology 60:6, pages 509-523.
Crossref
Marco Lombardo, Norberto Micali, Valentina Villari, Sebastiano Serrao, Giuseppe Pucci, Riccardo Barberi & Giuseppe Lombardo. (2015) Ultraviolet A: Visible spectral absorbance of the human cornea after transepithelial soaking with dextran-enriched and dextran-free riboflavin 0.1% ophthalmic solutions. Journal of Cataract and Refractive Surgery 41:10, pages 2283-2290.
Crossref
Nada H. Aldahlawi, Sally Hayes, David P.S. O’Brart & Keith M. Meek. (2015) Standard versus accelerated riboflavin–ultraviolet corneal collagen crosslinking: Resistance against enzymatic digestion. Journal of Cataract and Refractive Surgery 41:9, pages 1989-1996.
Crossref
Frederik Raiskup & Mark Hillen. (2015) Corneal Cross-linking can halt the Progression of Keratoconus, but what is the Best Approach to Treatment?. International Journal of Keratoconus and Ectatic Corneal Diseases 4:2, pages 47-51.
Crossref
Songeun Beack, Jun-Sub Choi, Jun Ho Lee, Hyemin Kim, Ki Hean Kim, Choun-Ki Joo & Sei Kwang Hahn. (2015) Two-photon microscopy of a Flt1 peptide–hyaluronate conjugate. Nanomedicine 10:15, pages 2315-2324.
Crossref
Pablo Peña-García, Pablo Sanz-Díez & María Luisa Durán-García. (2015) Keratoconus Management Guidelines. International Journal of Keratoconus and Ectatic Corneal Diseases 4:1, pages 1-39.
Crossref
Marco Lombardo, Sebastiano Serrao, Giovanni Carbone & Giuseppe Lombardo. (2015) Corneal light backscattering after transepithelial corneal crosslinking using iontophoresis in donor human corneal tissue. Journal of Cataract and Refractive Surgery 41:3, pages 635-643.
Crossref
Marco Lombardo, Giuseppe Pucci, Riccardo Barberi & Giuseppe Lombardo. (2015) Interaction of ultraviolet light with the cornea: Clinical implications for corneal crosslinking. Journal of Cataract and Refractive Surgery 41:2, pages 446-459.
Crossref
Xiao Zhang, Xiang-chen Tao, Jian Zhang, Zhi-wei Li, Yan-yun Xu, Yu-meng Wang, Chun-xiao Zhang & Guo-ying Mu. (2015) A Review of Collagen Cross-Linking in Cornea and Sclera. Journal of Ophthalmology 2015, pages 1-12.
Crossref
Z Shalchi, X Wang & M A Nanavaty. (2014) Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus. Eye 29:1, pages 15-29.
Crossref
Sebastian P. Lesniak & Peter S. Hersh. (2014) Transepithelial corneal collagen crosslinking for keratoconus: Six-month results. Journal of Cataract and Refractive Surgery 40:12, pages 1971-1979.
Crossref
Raksha Urs, Harriet O. Lloyd & Ronald H. Silverman. (2014) Acoustic Radiation Force for Noninvasive Evaluation of Corneal Biomechanical Changes Induced by Cross‐linking Therapy. Journal of Ultrasound in Medicine 33:8, pages 1417-1426.
Crossref
Andre A.M. Torricelli, Matthew R. Ford, Vivek Singh, Marcony R. Santhiago, William J. DuppsJr.Jr. & Steven E. Wilson. (2014) BAC-EDTA transepithelial riboflavin-UVA crosslinking has greater biomechanical stiffening effect than standard epithelium-off in rabbit corneas. Experimental Eye Research 125, pages 114-117.
Crossref
Praveena Gupta, Best Anyama, Kert Edward, Kevin Wells, Massoud Motamedi, Bernard F. Godley & Gracie Vargas. (2014) Depth Resolved Differences After Corneal Crosslinking With and Without Epithelial Debridement Using Multimodal Imaging. Translational Vision Science & Technology 3:4, pages 5.
Crossref
Banu Torun Acar, Canan Asli Utine, Vildan Ozturk, Suphi Acar & Ferda Ciftci. (2014) Can the Effect of Transepithelial Corneal Collagen Cross-linking Be Improved by Increasing the Duration of Topical Riboflavin Application? An In Vivo Confocal Microscopy Study. Eye & Contact Lens: Science & Clinical Practice 40:4, pages 207-212.
Crossref
David P.S. O’Brart. (2014) Corneal collagen cross-linking: A review. Journal of Optometry 7:3, pages 113-124.
Crossref
Nir Sorkin & David Varssano. (2014) Corneal Collagen Crosslinking: A Systematic Review. Ophthalmologica 232:1, pages 10-27.
Crossref
Aleksandar Stojanovic, Wen Zhou & Tor Paaske Utheim. (2014) Corneal Collagen Cross-Linking with and without Epithelial Removal: A Contralateral Study with 0.5% Hypotonic Riboflavin Solution. BioMed Research International 2014, pages 1-9.
Crossref
Suphi Taneri, Saskia Oehler, Grace Lytle & H. Burkhard Dick. (2014) Evaluation of Epithelial Integrity with Various Transepithelial Corneal Cross-Linking Protocols for Treatment of Keratoconus. Journal of Ophthalmology 2014, pages 1-5.
Crossref
Brian K. Armstrong, Michelle P. Lin, Matthew R. Ford, Marcony R. Santhiago, Vivek Singh, Gregory H. Grossman, Vandana Agrawal, Abhijit Sinha Roy, Robert S. Butler, William J. Dupps & Steven E. Wilson. (2013) Biological and Biomechanical Responses to Traditional Epithelium-Off and Transepithelial Riboflavin-UVA CXL Techniques in Rabbits. Journal of Refractive Surgery 29:5, pages 332-341.
Crossref
Frederik Raiskup & Eberhard Spoerl. (2013) Corneal Crosslinking with Riboflavin and Ultraviolet A. Part II. Clinical Indications and Results. The Ocular Surface 11:2, pages 93-108.
Crossref
Frederik Raiskup & Eberhard Spoerl. (2013) Corneal Crosslinking with Riboflavin and Ultraviolet A. I. Principles. The Ocular Surface 11:2, pages 65-74.
Crossref
Keith M Meek & Sally Hayes. (2013) Corneal cross‐linking – a review. Ophthalmic and Physiological Optics 33:2, pages 78-93.
Crossref
Quan Wen, Stephen L. Trokel, MiJung Kim & David C. Paik. (2013) Aliphatic β-Nitroalcohols for Therapeutic Corneoscleral Cross-Linking. Cornea 32:2, pages 179-184.
Crossref
Xiangchen Tao, Haiqun Yu, Yong Zhang, Zhiwei Li, Vishal Jhanji, Shouxiang Ni, Ya Wang & Guoying Mu. (2013) Role of Corneal Epithelium in Riboflavin/Ultraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International 2013, pages 1-6.
Crossref
Carmine Ostacolo, Ciro Caruso, Diana Tronino, Salvatore Troisi, Sonia Laneri, Luigi Pacente, Antonio Del Prete & Antonia Sacchi. (2013) Enhancement of corneal permeation of riboflavin-5′-phosphate through vitamin E TPGS: A promising approach in corneal trans-epithelial cross linking treatment. International Journal of Pharmaceutics 440:2, pages 148-153.
Crossref
Lamis Abdelaziz, Hanna Garzozi & Ankur Barua. (2012) Collagen Corneal Cross-linking and the Epithelium. International Journal of Keratoconus and Ectatic Corneal Diseases 1:3, pages 179-184.
Crossref
Chintan Malhotra, Rohit Shetty, Rajesh S. Kumar, Himabindu Veluri, Harsha Nagaraj & K. Bhujang Shetty. (2012) In Vivo Imaging of Riboflavin Penetration During Collagen Cross-linking With Hand-held Spectral Domain Optical Coherence Tomography. Journal of Refractive Surgery 28:11, pages 776-780.
Crossref
Carina Koppen, Kristien Wouters, Danny Mathysen, Jos Rozema & Marie-José Tassignon. (2012) Refractive and topographic results of benzalkonium chloride–assisted transepithelial crosslinking. Journal of Cataract and Refractive Surgery 38:6, pages 1000-1005.
Crossref
Andreas Thorsrud, Bjørn Nicolaissen & Liv Drolsum. (2012) Corneal collagen crosslinking in vitro: Inhibited regeneration of human limbal epithelial cells after riboflavin–ultraviolet-A exposure. Journal of Cataract and Refractive Surgery 38:6, pages 1072-1076.
Crossref
Tariq A. Alhamad, David P.S. O'Brart, Naomi A.L. O'Brart & Keith M. Meek. (2012) Evaluation of transepithelial stromal riboflavin absorption with enhanced riboflavin solution using spectrophotometry. Journal of Cataract and Refractive Surgery 38:5, pages 884-889.
Crossref
Aleksandar Stojanovic, Xiangjun Chen, Nan Jin, Ting Zhang, Filip Stojanovic, Sten Raeder & Tor Paaske Utheim. (2012) Safety and Efficacy of Epithelium-On Corneal Collagen Cross-Linking Using a Multifactorial Approach to Achieve Proper Stromal Riboflavin Saturation. Journal of Ophthalmology 2012, pages 1-8.
Crossref
Marine Hovakimyan, Rudolf F. Guthoff & Oliver Stachs. (2012) Collagen Cross-Linking: Current Status and Future Directions. Journal of Ophthalmology 2012, pages 1-12.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.