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Current Eye Research Volume 36, 2011 - Issue 2
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Original Article

A Novel Thermodynamic Treatment for Meibomian Gland Dysfunction

Beth R. Friedland;TearScience, Inc., Morrisville, North Carolina, USA
,
Christopher P. Fleming;Park Ophthalmology, Durham, North Carolina, USA
,
Caroline A. Blackie;Western Wake Eye Center PA, Cary, North Carolina, USACorrespondence[email protected]
&
Donald R. Korb;Korb Associates, Boston, Massachusetts, USA
Pages 79-87 | Received 16 Mar 2010, Accepted 14 Jul 2010, Published online: 31 Jan 2011

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Brandon Bzovey & William Ngo. (2022) Eyelid Warming Devices: Safety, Efficacy, and Place in Therapy. Clinical Optometry 14, pages 133-147.
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Joseph Tauber, James Owen, Marc Bloomenstein, John Hovanesian & Mark A Bullimore. (2020) Comparison of the iLUX and the LipiFlow for the Treatment of Meibomian Gland Dysfunction and Symptoms: A Randomized Clinical Trial. Clinical Ophthalmology 14, pages 405-418.
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Giuseppe Giannaccare, Leonardo Taroni, Carlotta Senni & Vincenzo Scorcia. (2019) Intense Pulsed Light Therapy In The Treatment Of Meibomian Gland Dysfunction: Current Perspectives. Clinical Optometry 11, pages 113-126.
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David Badawi. (2018) A novel system, TearCare®, for the treatment of the signs and symptoms of dry eye disease. Clinical Ophthalmology 12, pages 683-694.
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Caroline A Blackie, Christy A Coleman, Kelly K Nichols, Lyndon Jones, Peter Q Chen, Ron Melton, David L Kading, Leslie E O’Dell & Sruthi Srinivasan. (2018) A single vectored thermal pulsation treatment for meibomian gland dysfunction increases mean comfortable contact lens wearing time by approximately 4 hours per day. Clinical Ophthalmology 12, pages 169-183.
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Alice T Epitropoulos, Krysta Goslin, Raman Bedi & Caroline A Blackie. (2017) Meibomian gland dysfunction patients with novel Sjögren’s syndrome biomarkers benefit significantly from a single vectored thermal pulsation procedure: a retrospective analysis. Clinical Ophthalmology 11, pages 701-706.
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Jing Qiao & Xiaoming Yan. (2013) Emerging treatment options for meibomian gland dysfunction. Clinical Ophthalmology 7, pages 1797-1803.
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Jack V. Greiner. (2012) A Single LipiFlow® Thermal Pulsation System Treatment Improves Meibomian Gland Function and Reduces Dry Eye Symptoms for 9 Months. Current Eye Research 37:4, pages 272-278.
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Articles from other publishers (51)

Purvasha Narang, Pragnya Rao Donthineni, Sharon D’Souza & Sayan Basu. (2023) Evaporative dry eye disease due to meibomian gland dysfunction: Preferred practice pattern guidelines for diagnosis and treatment. Indian Journal of Ophthalmology 71:4, pages 1348-1356.
Crossref
Erin A. Hisey, Anat Galor & Brian C. Leonard. (2023) A comparative review of evaporative dry eye disease and meibomian gland dysfunction in dogs and humans. Veterinary Ophthalmology 26:S1, pages 16-30.
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Andrew D Pucker, Erin Rueff, William Ngo, Anna A Tichenor & John E Conto. (2022) LipiFlow for the treatment of dry eye disease. Cochrane Database of Systematic Reviews 2022:12.
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Andrea Novo-Diez, Alberto López-Miguel, Itziar Fernández, Marta Blanco-Vázquez, Cristina Valencia-Sandonís, Amalia Enríquez-de-Salamanca, María J. González-García & Margarita Calonge. (2022) Effect of a single vectored thermal pulsation treatment of Meibomian gland dysfunction patients under controlled environmental conditions. Scientific Reports 12:1.
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Youngsub Eom, Boram Kang, Xiangzhe Li, Ho Sik Hwang, Hyung Keun Lee, Hyo Myung Kim & Jong Suk Song. (2022) Change in rat meibomian gland structure with external pressure on the eyelid. Contact Lens and Anterior Eye 45:5, pages 101523.
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Marie Wangen Beining, Morten Schjerven Magnø, Emily Moschowits, Jonatan Olafsson, Jelle Vehof, Darlene A. Dartt & Tor Paaske Utheim. (2022) In-office thermal systems for the treatment of dry eye disease. Survey of Ophthalmology 67:5, pages 1405-1418.
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I. B. Medvedev, V. N. Trubilin, E. G. Poluninа, N. N. Dergacheva, D. V. Andzhelova & Yu. V. Evstigneeva. (2022) Modern Possibilities of Physiotherapeutic Treatment in Meibomian Gland Dysfunction. Ophthalmology in Russia 19:2, pages 235-241.
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Christoph Laufenböck. (2021) Thermo-Pulsations-System (LipiFLow®) zur Behandlung der Meibom-Drüsen-Dysfunktion (MDD) aus der Sicht eines niedergelassenen AugenfacharztesThermal pulsation system (LipiFlow®) for treatment of meibomian gland dysfunction (MGD) from the perspective of an ophthalmologist in private practice. Die Ophthalmologie 119:6, pages 605-610.
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David Schanzlin, James P. Owen, Steve Klein, Thao N. Yeh, Mohinder M. Merchea & Mark A. Bullimore. (2022) Efficacy of the Systane iLux Thermal Pulsation System for the Treatment of Meibomian Gland Dysfunction After 1 Week and 1 Month: A Prospective Study. Eye & Contact Lens: Science & Clinical Practice 48:4, pages 155-161.
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Siyuan Li, Ke Yang, Jingyi Wang, Shang Li, Lei Zhu, Jun Feng, Lei Tian & Ying Jie. (2021) Effect of a Novel Thermostatic Device on Meibomian Gland Dysfunction: A Randomized Controlled Trial in Chinese Patients. Ophthalmology and Therapy 11:1, pages 261-270.
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J.V. García-Marqués, C. Talens-Estarelles, N. Martínez-Albert, S. García-Lázaro & A. Cerviño. (2022) Evaluation of the MGDRx eyebag treatment in young and older subjects with dry eye symptoms. Journal Français d'Ophtalmologie 45:1, pages 20-27.
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Jindong Hu, Sixing Zhu & Xinquan Liu. (2021) Efficacy and safety of a vectored thermal pulsation system (Lipiflow®) in the treatment of meibomian gland dysfunction: a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 260:1, pages 25-39.
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Shamis Fallah & Christopher J. Loer. (2021) Effects of Vectored Thermal Pulsation on Objective Tear Film Measures. Cornea 40:12, pages 1594-1599.
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Nurhan Sutcliffe, Alberto Recchioni, Shireen Hilmi, Saaeha Rauz & Anwar R Tappuni. (2021) What’s new in ocular and oral aspects of Sjögren’s syndrome and do new treatments work?. Rheumatology 60:3, pages 1034-1041.
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Laura Valencia-Nieto, Andrea Novo-Diez, Marta Blanco-Vázquez & Alberto López-Miguel. (2020) Therapeutic Instruments Targeting Meibomian Gland Dysfunction. Ophthalmology and Therapy 9:4, pages 797-807.
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Hye Jee KimJin Hyoung Park. (2020) Clinical Efficacy of Immediate Manual Meibomian Gland Expression After Thermal Pulsation (LipiFlow) for Obstructive Meibomian Gland Dysfunction: Comparison With Thermal Pulsation. Cornea 39:8, pages 975-979.
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Inge Kremers, Bettina Hohberger & Antonio Bergua. (2020) Infrared thermography: different options of thermal eyelid warming. Graefe's Archive for Clinical and Experimental Ophthalmology 258:7, pages 1515-1522.
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Michael T.M. Wang, Lucy J. Liu, Robert D. McPherson, J. Robert Fuller & Jennifer P. Craig. (2020) Therapeutic profile of a latent heat eyelid warming device with temperature setting variation. Contact Lens and Anterior Eye 43:2, pages 173-177.
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Stephanie Wong, Sruthi Srinivasan, Paul J. Murphy & Lyndon Jones. (2019) Comparison of meibomian gland dropout using two infrared imaging devices. Contact Lens and Anterior Eye 42:3, pages 311-317.
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William Ngo, Sruthi Srinivasan & Lyndon Jones. (2019) An Eyelid Warming Device for the Management of Meibomian Gland Dysfunction. Journal of Optometry 12:2, pages 120-130.
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Douglas Borchman. (2019) The optimum temperature for the heat therapy for meibomian gland dysfunction. The Ocular Surface 17:2, pages 360-364.
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Cordula DahlmannCordula Dahlmann. 2019. Sicca-Syndrom. Sicca-Syndrom 97 146 .
Shiro Amano. (2018) Meibomian Gland Dysfunction: Recent Progress Worldwide and in Japan. Investigative Opthalmology & Visual Science 59:14, pages DES87.
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Natalia Hernández-Martínez, Oscar Fernández-Vizcaya, Cristina Pacheco-Del Valle, Regina Velasco-Ramos, Alejandro Babayán-Sosa, Elisa Alegría-Gómez, Diana Raya-Hernández & Oscar Baca-Lozada. (2018) Comparación entre la aplicación de calor local mediante un dispositivo termoeléctrico, aseos palpebrales con champú del aceite del árbol de té y tratamiento convencional en pacientes con disfunción de glándulas de meibomio de la tercera edad. Revista Mexicana de Oftalmología 92:6S, pages 278-285.
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William Ngo, Sruthi Srinivasan & Lyndon Jones. (2018) A Comparison of Dry Eye Diagnostic Tests Between Symptomatic and Asymptomatic Age-Matched Females. Eye & Contact Lens: Science & Clinical Practice 44:1, pages S110-S114.
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Jacqueline Tan, Lily Ho, Katherine Wong, Alma La, Sylbi Lee, Sarah Park, Larissa Tran & Fiona Stapleton. (2018) The effects of a hydrating mask compared to traditional warm compresses on tear film properties in meibomian gland dysfunction. Contact Lens and Anterior Eye 41:1, pages 83-87.
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Kannan Sridharan & Gowri Sivaramakrishnan. (2017) Therapies for Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The Open Ophthalmology Journal 11:1, pages 346-354.
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Allister Gibbons, Daniel Waren, Nilufer Yesilirmak, Kendra Davis, Felipe Valenzuela, Juan C. Murillo & Victor L. Perez. (2017) Ocular Surface Parameters Predicting Patient Satisfaction After a Single Vectored Thermal Pulsation Procedure for Management of Symptomatic Meibomian Gland Dysfunction. Cornea 36:6, pages 679-683.
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Yang Zhao, Anuradha Veerappan, Sharon Yeo, David M. Rooney, Rajendra U. Acharya, Jen Hong Tan & Louis Tong. (2016) Clinical Trial of Thermal Pulsation (LipiFlow) in Meibomian Gland Dysfunction With Preteatment Meibography. Eye & Contact Lens: Science & Clinical Practice 42:6, pages 339-346.
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Gernot Petzold, Raman Bedi & Caroline A. Blackie. (2016) Management of dry-eye syndrome after laser in situ keratomileusis with a vectored thermal pulsation system. JCRS Online Case Reports 4:2, pages 34-37.
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Jack V. Greiner. (2016) Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms. Eye & Contact Lens: Science & Clinical Practice 42:2, pages 99-107.
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Michael B. Hynes, Matthew C. Bujak, Emmanuel Chérin, Shachar Sade & F. Stuart Foster. (2016) Design of a Subtarsal Ultrasonic Transducer for Mild Hyperthermia Treatment of Dry Eye Disease. Ultrasound in Medicine & Biology 42:1, pages 232-242.
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Michael T.M. Wang, Akilesh Gokul & Jennifer P. Craig. (2015) Temperature profiles of patient-applied eyelid warming therapies. Contact Lens and Anterior Eye 38:6, pages 430-434.
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Reiko Arita, Naoyuki Morishige, Rika Shirakawa, Yoichi Sato & Shiro Amano. (2015) Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction. The Ocular Surface 13:4, pages 321-330.
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William Ngo, Barbara Caffery, Sruthi Srinivasan & Lyndon W. Jones. (2015) Effect of Lid Debridement-Scaling in Sjögren Syndrome Dry Eye. Optometry and Vision Science 92:9, pages e316-e320.
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Michael T. M. Wang, Zenia Jaitley, Sarah M. Lord & Jennifer P. Craig. (2015) Comparison of Self-applied Heat Therapy for Meibomian Gland Dysfunction. Optometry and Vision Science 92:9, pages e321-e326.
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Caroline A. Blackie, Alan N. Carlson & Donald R. Korb. (2015) Treatment for meibomian gland dysfunction and dry eye symptoms with a single-dose vectored thermal pulsation. Current Opinion in Ophthalmology 26:4, pages 306-313.
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Edoardo Villani, Elena Garoli, Veronica Canton, Francesco Pichi, Paolo Nucci & Roberto Ratiglia. (2014) Evaluation of a novel eyelid-warming device in meibomian gland dysfunction unresponsive to traditional warm compress treatment: an in vivo confocal study. International Ophthalmology 35:3, pages 319-323.
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Paramdeep Singh Bilkhu, Shehzad Anjam Naroo & James Stuart Wolffsohn. (2014) Randomised masked clinical trial of the MGDRx eyebag for the treatment of meibomian gland dysfunction-related evaporative dry eye. British Journal of Ophthalmology 98:12, pages 1707-1711.
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David Finis, Claudia König, Jasmin Hayajneh, Maria Borrelli, Stefan Schrader & Gerd Geerling. (2014) Six-Month Effects of a Thermodynamic Treatment for MGD and Implications of Meibomian Gland Atrophy. Cornea 33:12, pages 1265-1270.
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U. Rajendra Acharya, Jen Hong Tan, S. Vidya, Sharon Yeo, Cheah Loon Too, Wei Jie Eugene Lim, Kuang Chua Chua & Louis Tong. (2014) Diagnosis of response and non-response to dry eye treatment using infrared thermography images. Infrared Physics & Technology 67, pages 497-503.
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Yureeda Qazi, Shruti Aggarwal & Pedram Hamrah. (2014) Image-guided evaluation and monitoring of treatment response in patients with dry eye disease. Graefe's Archive for Clinical and Experimental Ophthalmology 252:6, pages 857-872.
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David Finis, Jasmin Hayajneh, Claudia K?nig, Maria Borrelli, Stefan Schrader & Gerd Geerling. (2014) Evaluation of an Automated Thermodynamic Treatment (LipiFlow?) System for Meibomian Gland Dysfunction: A Prospective, Randomized, Observer-Masked Trial. The Ocular Surface 12:2, pages 146-154.
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A. Baumann & B. Cochener. (2014) Évaluation des moyens modernes de prise en charge du dysfonctionnement meibomien. Journal Français d'Ophtalmologie 37:4, pages 303-312.
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Jack V Greiner. (2013) Long-term (12-month) improvement in meibomian gland function and reduced dry eye symptoms with a single thermal pulsation treatment. Clinical & Experimental Ophthalmology 41:6, pages 524-530.
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Norihiko YokoiSruthi SrinivasanLyndon Jones. 2013. Dry Eye Syndrome: Basic and Clinical Perspectives. Dry Eye Syndrome: Basic and Clinical Perspectives 30 49 .
Donald R. Korb & Caroline A. Blackie. (2013) Case Report. Eye & Contact Lens: Science & Clinical Practice 39:3, pages e1-e3.
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Juan Murube. (2013) Ocular Cosmetics in Modern Times. The Ocular Surface 11:2, pages 60-64.
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Kristina Lindsley, Sueko Matsumura, Elham Hatef & Esen K Akpek. (2012) Interventions for chronic blepharitis. Cochrane Database of Systematic Reviews.
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Stephen S. Lane, Harvey B. DuBiner, Randy J. Epstein, Paul H. Ernest, Jack V. Greiner, David R. Hardten, Edward J. Holland, Michael A. Lemp, James E. McDonald, David I. Silbert, Caroline A. Blackie, Christy A. Stevens & Raman Bedi. (2012) A New System, the LipiFlow, for the Treatment of Meibomian Gland Dysfunction. Cornea 31:4, pages 396-404.
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Donald R Korb & Caroline A Blackie. (2011) Meibomian Gland Therapeutic Expression: Quantifying the Applied Pressure and the Limitation of Resulting Pain. Eye & Contact Lens: Science & Clinical Practice 37:5, pages 298-301.
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