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Current Eye Research Volume 36, 2011 - Issue 3
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Original Article

Validation of the Flush Method as an Alternative to Basal or Reflex Tear Collection

Maria Markoulli;Brien Holden Vision Institute, Sydney, AustraliaCorrespondence[email protected]
,
Eric Papas;School of Optometry & Vision Science, University of New South Wales, Sydney, Australia
,
Andrea Petznick;Vision Cooperative Research Centre, Sydney, Australia
&
Brien Holden;Brien Holden Vision Institute, Sydney, Australia
Pages 198-207 | Received 02 Jul 2010, Accepted 21 Nov 2010, Published online: 28 Jan 2011

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Stefano Bonini, Antonio Di Zazzo, Pier Luigi Surico, Bijorn Omar Balzamino, Vitaliana Luccarelli, Matteo Niutta, Marco Coassin & Alessandra Micera. (2023) Inflammation and Dry Eye-like Symptoms as Concomitant Manifestations of Laryngo-Pharyngeal Reflux. Current Eye Research 48:8, pages 724-730.
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Sultan Alotaibi, Maria Markoulli, Jerome Ozkan & Eric Papas. (2022) Bio-chemical markers of chronic, non-infectious disease in the human tear film. Clinical and Experimental Optometry 105:2, pages 166-176.
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Somin Ahn, Youngsub Eom, Boram Kang, Jungboung Park, Hyung Keun Lee, Hyo Myung Kim & Jong Suk Song. (2018) Effects of Menthol-Containing Artificial Tears on Tear Stimulation and Ocular Surface Integrity in Normal and Dry Eye Rat Models. Current Eye Research 43:5, pages 580-587.
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Izabela K. Garaszczuk, Robert Montes Mico, D. Robert Iskander & Alejandro Cerviño Expósito. (2018) The tear turnover and tear clearance tests – a review. Expert Review of Medical Devices 15:3, pages 219-229.
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Sultan Alotaibi, Eric Papas, Jerome Ozkan, Stuti L. Misra & Maria Markoulli. (2023) Behaviour of hTERT in the tears of neophyte contact lens wearers during the sleep/wake cycle. Contact Lens and Anterior Eye 46:6, pages 102060.
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Mian Wu, Xingna Hu, Ting Lu, Chenxiao Liu & Honghong Lu. (2023) Uric acid is independently associated with interleukin‐1β levels in tear fluid of hyperuricemia and gout patients. Immunity, Inflammation and Disease 11:3.
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Yu-Ting Hsiao, Yu-Ting Huang, Hun-Ju Yu, Po-Chiung Fang & Ming-Tse Kuo. (2022) Tear Proteomics Approach to Distinguishing Primary from Secondary Sjögren’s Syndrome for Dry Eye Patients with Long-Term Instillation of Eyedrops. International Journal of Molecular Sciences 23:23, pages 15239.
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Maria Markoulli, Katherine Wong, Tianni Jia, Jaya Sowjanya Siddireddy, Nancy Briggs & Jacqueline Tan. (2022) The effect of hydroxypropyl-guar nanoemulsion on signs and symptoms of dry eye. Contact Lens and Anterior Eye 45:6, pages 101736.
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Mateusz Winiarczyk, Katarzyna Biela, Katarzyna Michalak, Dagmara Winiarczyk & Jerzy Mackiewicz. (2022) Changes in Tear Proteomic Profile in Ocular Diseases. International Journal of Environmental Research and Public Health 19:20, pages 13341.
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Janika Nättinen, Ulla Aapola, Praveena Nukareddy & Hannu Uusitalo. (2021) Looking deeper into ocular surface health: an introduction to clinical tear proteomics analysis. Acta Ophthalmologica 100:5, pages 486-498.
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Simin Masoudi. (2022) Biochemistry of human tear film: A review. Experimental Eye Research 220, pages 109101.
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Kristina Krajcikova, Gabriela Glinska & Vladimira Tomeckova. (2022) Effect of tear fluid sampling and processing on total protein quantity and electrophoretic pattern. Taiwan Journal of Ophthalmology 12:1, pages 88.
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Janusz Pieczyński, Urszula Szulc, Joanna Harazna, Aleksandra Szulc & Jolanta Kiewisz. (2021) Tear fluid collection methods: Review of current techniques. European Journal of Ophthalmology 31:5, pages 2245-2251.
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Xiangzhe Li, Boram Kang, Youngsub Eom, Hyung Keun Lee, Hyo Myung Kim & Jong Suk Song. (2020) The Protective Effect of an Eye Wash Solution on the Ocular Surface Damage Induced by Airborne Carbon Black Exposure. Cornea 39:8, pages 1040-1047.
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Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi & Aydogan Ozcan. (2020) Contact lens-based lysozyme detection in tear using a mobile sensor. Lab on a Chip 20:8, pages 1493-1502.
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Waleed Alghamdi, Maria Markoulli & Eric Papas. (2020) The relationship between tear film MMP-9 and meibomian gland changes during soft contact lens wear. Contact Lens and Anterior Eye 43:2, pages 154-158.
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Runzhong Fu, Wannita Klinngam, Martin Heur, Maria C. Edman & Sarah F. Hamm-Alvarez. (2020) Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease. Eye & Contact Lens: Science & Clinical Practice 46:2, pages S70-S83.
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Debarun Dutta, Juno Kim, Merna Sarkes, Suneeta Nath & Maria Markoulli. (2019) The repeatability of subjective and objective tear ferning assessment and its association with lipid layer thickness, non-invasive tear break-up time and comfort. Contact Lens and Anterior Eye 42:4, pages 420-427.
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Martin W. Hümmert, Ulrich Wurster, Lena Bönig, Philipp Schwenkenbecher, Kurt-Wolfram Sühs, Sascha Alvermann, Stefan Gingele, Thomas Skripuletz & Martin Stangel. (2019) Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients. Frontiers in Immunology 10.
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Xiangzhe Li, Boram Kang, In Ho Woo, Youngsub Eom, Hyung Keun Lee, Hyo Myung Kim & Jong Suk Song. (2018) Effects of Topical Mucolytic Agents on the Tears and Ocular Surface: A Plausible Animal Model of Mucin-Deficient Dry Eye. Investigative Opthalmology & Visual Science 59:7, pages 3104.
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Roshni Patel, Meifang Zhu & Danielle M. Robertson. (2018) Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye. Growth Hormone & IGF Research 40, pages 69-73.
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Aniko Rentka, Krisztina Koroskenyi, Jolan Harsfalvi, Zoltan Szekanecz, Gabriella Szucs, Peter Szodoray & Adam Kemeny-Beke. (2017) Evaluation of commonly used tear sampling methods and their relevance in subsequent biochemical analysis. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 54:5, pages 521-529.
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Maria Markoulli, Moneisha Gokhale & Jingjing You. (2017) Substance P in Flush Tears and Schirmer Strips of Healthy Participants. Optometry and Vision Science 94:4, pages 527-533.
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Mikel Azkargorta, Javier Soria, Arantxa Acera, Ibon Iloro & Felix Elortza. (2017) Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice. Journal of Proteomics 150, pages 359-367.
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Vitaly Avilov, Qi Zeng & Scott A. Shippy. (2016) Threads for tear film collection and support in quantitative amino acid analysis. Analytical and Bioanalytical Chemistry 408:19, pages 5309-5317.
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Sin Man Lam, Louis Tong, Xinrui Duan, Andrea Petznick, Markus R. Wenk & Guanghou Shui. (2014) Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles. Journal of Lipid Research 55:2, pages 289-298.
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Suzanne Hagan & Alan Tomlinson. (2013) Tear Fluid Biomarker Profiling: A Review of Multiplex Bead Analysis. The Ocular Surface 11:4, pages 219-235.
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Lei Zhou, Ruihua Wei, Ping Zhao, Siew Kwan Koh, Roger W. Beuerman & Chuanqing Ding. (2013) Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sjögren's syndrome-associated dry eye. PROTEOMICS 13:16, pages 2469-2481.
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Maria Markoulli, Eric Papas, Nerida Cole & Brien Holden. (2013) Effect of Contact Lens Wear on the Diurnal Profile of Matrix Metalloproteinase 9 in Tears. Optometry and Vision Science 90:5, pages 419-429.
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Eliana Farias, Katia L. Yasunaga, Romulo V.R. Peixoto, Micaella P. Fonseca, Wagner Fontes & Paula D. Galera. (2013) Comparison of two methods of tear sampling for protein quantification by Bradford method. Pesquisa Veterinária Brasileira 33:2, pages 261-264.
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Seung Yong LeeMee Jung KimMee Kum KimWon Ryang Wee. (2013) Comparative Analysis of Polymerase Chain Reaction Assay for Herpes Simplex Virus 1 Detection in Tear. Korean Journal of Ophthalmology 27:5, pages 316.
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Lei Zhou & Roger W. Beuerman. (2012) Tear analysis in ocular surface diseases. Progress in Retinal and Eye Research 31:6, pages 527-550.
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