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Research Article

Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET

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Pages 922-933 | Received 01 Jun 2010, Accepted 21 Jun 2010, Published online: 13 Sep 2010

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Morten Busk, Ole L. Munk, Steen S. Jakobsen & Michael R. Horsman. (2017) Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity. Acta Oncologica 56:11, pages 1583-1590.
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Ane B. Iversen, Steffen Ringgaard, Christoffer Laustsen, Hans Stødkilde-Jørgensen, Lise Bentzen, Morten Busk & Michael R. Horsman. (2015) Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia. Acta Oncologica 54:9, pages 1393-1398.
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Linda J. Wack, David Mönnich, Wouter van Elmpt, Catharina M. L. Zegers, Esther G. C. Troost, Daniel Zips & Daniela Thorwarth. (2015) Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia – a simulation study. Acta Oncologica 54:9, pages 1370-1377.
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Morten Busk, Steen Jakobsen, Michael R. Horsman, Lise S. Mortensen, Ane B. Iversen, Jens Overgaard, Marianne Nordsmark, Xiaosheng Ji, David Y. Lee & James R. Raleigh. (2013) PET imaging of tumor hypoxia using 18F-labeled pimonidazole. Acta Oncologica 52:7, pages 1300-1307.
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Cai Grau, Dag Rune Olsen, Jens Overgaard, Morten Høyer, Jacob Christian Lindegaard & Ludvig Paul Muren. (2010) Biology-guided adaptive radiation therapy – presence or future?. Acta Oncologica 49:7, pages 884-887.
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Articles from other publishers (25)

Sofia Nascimento dos Santos, Melinda Wuest, Hans-Sonke Jans, Jenilee Woodfield, Arian Pérez Nario, Daniel Krys, Jennifer Dufour, Darryl Glubrecht, Cody Bergman, Emerson Soares Bernardes & Frank Wuest. (2023) Comparison of three 18F-labeled 2-nitroimidazoles for imaging hypoxia in breast cancer xenografts: [18F]FBNA, [18F]FAZA and [18F]FMISO. Nuclear Medicine and Biology 124-125, pages 108383.
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Brian W. Pogue, Xu Cao, Harold M. Swartz & Sergei A. Vinogradov. (2021) Review of Tissue Oxygenation Sensing During Radiotherapy Based Upon Cherenkov-Excited Luminescence Imaging. Applied Magnetic Resonance 52:10, pages 1521-1536.
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Pernille B. Elming, Thomas R. Wittenborn, Morten Busk, Brita S. Sørensen, Mathilde Borg Houlberg Thomsen, Trine Strandgaard, Lars Dyrskjøt, Steffen Nielsen & Michael R. Horsman. (2021) Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts. Cancers 13:11, pages 2602.
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Morten Busk, Jens Overgaard & Michael R. Horsman. (2020) Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions. Seminars in Nuclear Medicine 50:6, pages 562-583.
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Heidi Espedal, Tina Fonnes, Kristine E. Fasmer, Camilla Krakstad & Ingfrid S. Haldorsen. (2019) Imaging of Preclinical Endometrial Cancer Models for Monitoring Tumor Progression and Response to Targeted Therapy. Cancers 11:12, pages 1885.
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Florian Maier, Anna Schweifer, Vijaya Damaraju, Carol Cass, Gregory Bowden, Walter Ehrlichmann, Manfred Kneilling, Bernd Pichler, Friedrich Hammerschmidt & Gerald Reischl. (2019) 2-Nitroimidazole-Furanoside Derivatives for Hypoxia Imaging—Investigation of Nucleoside Transporter Interaction, 18F-Labeling and Preclinical PET Imaging. Pharmaceuticals 12:1, pages 31.
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Jan Schuemann, Niels Bassler & Taku Inaniwa. (2018) Computational models and tools. Medical Physics 45:11.
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Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley & David A. Jaffray. (2017) Impact of tissue transport on PET hypoxia quantification in pancreatic tumours. EJNMMI Research 7:1.
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L. J. Wack, D. Mönnich, A. Yaromina, D. Zips, M. Baumann & D. Thorwarth. (2016) Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O 2 consumption? . Medical Physics 43:7, pages 4113-4121.
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Milan Grkovski, Jazmin Schwartz, Mithat Gönen, Heiko Schöder, Nancy Y. Lee, Sean D. Carlin, Pat B. Zanzonico, John L. Humm & Sadek A. Nehmeh. (2016) Feasibility of 18 F-Fluoromisonidazole Kinetic Modeling in Head and Neck Cancer Using Shortened Acquisition Times . Journal of Nuclear Medicine 57:3, pages 334-341.
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Jinzi Zheng, Stephan G. Klinz, Raquel De Souza, Jonathan Fitzgerald & David A. Jaffray. (2015) Longitudinal tumor hypoxia imaging with [18F]FAZA-PET provides early prediction of nanoliposomal irinotecan (nal-IRI) treatment activity. EJNMMI Research 5:1.
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Fan Li, Jesper Jørgensen, Jacob Madsen & Andreas Kjaer. (2015) Pharmacokinetic Analysis of 64Cu-ATSM Dynamic PET in Human Xenograft Tumors in Mice. Diagnostics 5:2, pages 96-112.
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Claudia Kuntner. (2014) Kinetic modeling in pre-clinical positron emission tomography. Zeitschrift für Medizinische Physik 24:4, pages 274-285.
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E.M. Hammond, M.-C. Asselin, D. Forster, J.P.B. O'Connor, J.M. Senra & K.J. Williams. (2014) The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic. Clinical Oncology 26:5, pages 277-288.
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Huiting Qiao, Jun Li, Yingmao Chen, Daifa Wang, Jintao Han, Mengqi Mei & Deyu Li. (2014) A study of the metabolism of transplanted tumor in the lung by micro PET/CT in mice. Medical Engineering & Physics 36:3, pages 294-299.
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Eline E Verwer. (2014) Positron emission tomography to assess hypoxia and perfusion in lung cancer. World Journal of Clinical Oncology 5:5, pages 824.
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Gyorgy B. Halmos, Leonie Bruine de Bruin, Johannes A. Langendijk, Bernard F. A. M. van der Laan, Jan Pruim & Roel J. H. M. Steenbakkers. (2014) Head and Neck Tumor Hypoxia Imaging by 18F-Fluoroazomycin-arabinoside (18F-FAZA)-PET. Clinical Nuclear Medicine 39:1, pages 44-48.
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Eline E. Verwer, Floris H. P. van Velden, Idris Bahce, Maqsood Yaqub, Robert C. Schuit, Albert D. Windhorst, Pieter Raijmakers, Adriaan A. Lammertsma, Egbert F. Smit & Ronald Boellaard. (2013) Pharmacokinetic analysis of [18F]FAZA in non-small cell lung cancer patients. European Journal of Nuclear Medicine and Molecular Imaging 40:10, pages 1523-1531.
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M. Busk, L. S. Mortensen, M. Nordsmark, J. Overgaard, S. Jakobsen, K. V. Hansen, J. Theil, J. F. Kallehauge, F. P. D’Andrea, T. Steiniche & M. R. Horsman. (2012) PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice. European Journal of Nuclear Medicine and Molecular Imaging 40:2, pages 186-197.
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Ali Gholamrezanezhad, Alin Chirindel & Rathan Subramaniam. 2012. PET-CT and PET-MRI in Oncology. PET-CT and PET-MRI in Oncology 279 322 .
Florian C Maier, Manfred Kneilling, Gerald Reischl, Funda Cay, Daniel Bukala, Andreas Schmid, Martin S Judenhofer, Martin Röcken, Hans-Jürgen Machulla & Bernd J Pichler. (2011) Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [18F]-fluoro-azomycinarabino-furanoside ([18F]FAZA). Radiation Oncology 6:1.
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Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen & Jens Overgaard. (2011) In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors. BMC Cancer 11:1.
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Constantin-Alin Maftei, Christine Bayer, Kuangyu Shi, Sabrina T. Astner & Peter Vaupel. (2011) Changes in the fraction of total hypoxia and hypoxia subtypes in human squamous cell carcinomas upon fractionated irradiation: Evaluation using pattern recognition in microcirculatory supply units. Radiotherapy and Oncology 101:1, pages 209-216.
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P. Vera, S. Thureau & P. Bohn. (2011) Traceurs de l’hypoxie en tomographie par émission de positons. Médecine Nucléaire 35:8, pages 433-444.
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Morten Busk, Stefan Walenta, Wolfgang Mueller-Klieser, Torben Steiniche, Steen Jakobsen, Michael Robert Horsman & Jens Overgaard. (2011) Inhibition of tumor lactate oxidation: Consequences for the tumor microenvironment. Radiotherapy and Oncology 99:3, pages 404-411.
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