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Letter to the Editor

Cardiac toxicity and radiation dose to the heart in definitive treated non-small cell lung cancer

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Pages 1058-1060 | Received 27 May 2010, Accepted 24 Jun 2010, Published online: 13 Sep 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Nicolai Jørgensen, Eric Leif Meline, Stefan Starup Jeppesen, Olfred Hansen, Morten Nielsen & Tine Schytte. (2019) The effect of tumor laterality on survival for non-small cell lung cancer patients treated with radiotherapy. Acta Oncologica 58:10, pages 1393-1398.
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Joshua R. Niska, Cameron S. Thorpe, Sorcha M. Allen, Thomas B. Daniels, William G. Rule, Steven E. Schild, Carlos E. Vargas & Farouk Mookadam. (2018) Radiation and the heart: systematic review of dosimetry and cardiac endpoints. Expert Review of Cardiovascular Therapy 16:12, pages 931-950.
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Olfred Hansen, Tine Schytte, Morten Nielsen & Carsten Brink. (2015) Age dependent prognosis in concurrent chemo-radiation of locally advanced NSCLC. Acta Oncologica 54:3, pages 333-339.
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Tine B. Nielsen, Olfred Hansen, Tine Schytte & Carsten Brink. (2014) Inhomogeneous dose escalation increases expected local control for NSCLC patients with lymph node involvement without increased mean lung dose. Acta Oncologica 53:1, pages 119-125.
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Anders Bertelsen, Olfred Hansen & Carsten Brink. (2012) Does VMAT for treatment of NSCLC patients increase the risk of pneumonitis compared to IMRT ? – A planning study. Acta Oncologica 51:6, pages 752-758.
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Gulhan Guler Avci, Gonca Altınısık Inan & Halis Bozkurt. (2022) The impact of the radiotherapy technique in sparing the heart substructures in central tumor irradiation in lung cancer. Journal of Radiotherapy in Practice 22.
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Azadeh Abravan, Gareth Price, Kathryn Banfill, Tom Marchant, Matthew Craddock, Joe Wood, Marianne C. Aznar, Alan McWilliam, Marcel van Herk & Corinne Faivre-Finn. (2022) Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy. Frontiers in Oncology 12.
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Katelyn M. Atkins, Danielle S. Bitterman, Tafadzwa L. Chaunzwa, David E. Kozono, Elizabeth H. Baldini, Hugo J.W.L. Aerts, Balaji K. Tamarappoo, Udo Hoffmann, Anju Nohria & Raymond H. Mak. (2021) Mean Heart Dose Is an Inadequate Surrogate for Left Anterior Descending Coronary Artery Dose and the Risk of Major Adverse Cardiac Events in Lung Cancer Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics 110:5, pages 1473-1479.
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Xin Sun, Yu Men, Jianyang Wang, Yongxing Bao, Xu Yang, Maoyuan Zhao, Shuang Sun, Meng Yuan, Zeliang Ma & Zhouguang Hui. (2021) Risk of cardiac‐related mortality in stage IIIA‐N2 non‐small cell lung cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) database . Thoracic Cancer 12:9, pages 1358-1365.
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Rita Steponavičienė, Justinas Jonušas, Romualdas Griškevičius, Jonas Venius & Saulius Cicėnas. (2021) A Pilot Study of Safer Radiation Dosage to the Heart and Its Subregions. Medicina 57:4, pages 320.
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Katelyn M. Atkins, Tafadzwa L. Chaunzwa, Nayan Lamba, Danielle S. Bitterman, Bhupendra Rawal, Jeremy Bredfeldt, Christopher L. Williams, David E. Kozono, Elizabeth H. Baldini, Anju Nohria, Udo Hoffmann, Hugo J. W. L. Aerts & Raymond H. Mak. (2021) Association of Left Anterior Descending Coronary Artery Radiation Dose With Major Adverse Cardiac Events and Mortality in Patients With Non–Small Cell Lung Cancer. JAMA Oncology 7:2, pages 206.
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Alan McWilliam, Jonathan Khalifa, Eliana Vasquez Osorio, Kathryn Banfill, Azadeh Abravan, Corinne Faivre-Finn & Marcel van Herk. (2020) Novel Methodology to Investigate the Effect of Radiation Dose to Heart Substructures on Overall Survival. International Journal of Radiation Oncology*Biology*Physics 108:4, pages 1073-1081.
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Alan McWilliam, Chloe Dootson, Lewis Graham, Kathryn Banfill, Azadeh Abravan & Marcel van Herk. (2020) Dose surface maps of the heart can identify regions associated with worse survival for lung cancer patients treated with radiotherapy. Physics and Imaging in Radiation Oncology 15, pages 46-51.
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Radovan Vojtíšek. (2020) Cardiac toxicity of lung cancer radiotherapy. Reports of Practical Oncology & Radiotherapy 25:1, pages 13-19.
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Tina Wanting Zhang, Jonatan Snir, R. Gabriel Boldt, George B. Rodrigues, Alexander V. Louie, Stewart Gaede, Ronald C. McGarry, James J. Urbanic, Megan E. Daly & David A. Palma. (2019) Is the Importance of Heart Dose Overstated in the Treatment of Non-Small Cell Lung Cancer? A Systematic Review of the Literature. International Journal of Radiation Oncology*Biology*Physics 104:3, pages 582-589.
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Katherine Lee Chuy, Omar Nahhas, Paari Dominic, Carlos Lopez, Emily Tonorezos, Robert Sidlow, David Straus & Dipti Gupta. (2019) Cardiovascular Complications Associated with Mediastinal Radiation. Current Treatment Options in Cardiovascular Medicine 21:7.
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Katelyn M. Atkins, Bhupendra Rawal, Tafadzwa L. Chaunzwa, Nayan Lamba, Danielle S. Bitterman, Christopher L. Williams, David E. Kozono, Elizabeth H. Baldini, Aileen B. Chen, Paul L. Nguyen, Anthony V. D’Amico, Anju Nohria, Udo Hoffmann, Hugo J.W.L. Aerts & Raymond H. Mak. (2019) Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer. Journal of the American College of Cardiology 73:23, pages 2976-2987.
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Nikhil Yegya-Raman, Kyle Wang, Sinae Kim, Meral Reyhan, Matthew P. Deek, Mutlay Sayan, Diana Li, Malini Patel, Jyoti Malhotra, Joseph Aisner, Lawrence B. Marks & Salma K. Jabbour. (2018) Dosimetric Predictors of Symptomatic Cardiac Events After Conventional-Dose Chemoradiation Therapy for Inoperable NSCLC. Journal of Thoracic Oncology 13:10, pages 1508-1518.
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Sung Joon Kim, Jeong Won Lee, Min Kyu Kang, Jae-Chul Kim, Jeong Eun Lee, Shin-Hyung Park, Mi Young Kim, Seoung-Jun Lee, Soo-Ho Moon & Byoung-Soo Ko. (2018) Evaluation of the hybrid-dynamic conformal arc therapy technique for radiotherapy of lung cancer. Radiation Oncology Journal 36:3, pages 241-247.
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Waqar Haque, Vivek Verma, Mohamad Fakhreddine, E. Brian Butler, Bin S. Teh & Charles B. SimoneIIII. (2018) Trends in Cardiac Mortality in Patients With Locally Advanced Non-Small Cell Lung Cancer. International Journal of Radiation Oncology*Biology*Physics 100:2, pages 470-477.
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José Belderbos, Laurie Gaspar, Ayse Nur Demiral & Lawrence B. Marks. 2018. IASLC Thoracic Oncology. IASLC Thoracic Oncology 393 408.e4 .
Charles B. SimoneIIII. (2017) New Era in Radiation Oncology for Lung Cancer: Recognizing the Importance of Cardiac Irradiation. Journal of Clinical Oncology 35:13, pages 1381-1383.
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Kyle Wang, Michael J. Eblan, Allison M. Deal, Matthew Lipner, Timothy M. Zagar, Yue Wang, Panayiotis Mavroidis, Carrie B. Lee, Brian C. Jensen, Julian G. Rosenman, Mark A. Socinski, Thomas E. Stinchcombe & Lawrence B. Marks. (2017) Cardiac Toxicity After Radiotherapy for Stage III Non–Small-Cell Lung Cancer: Pooled Analysis of Dose-Escalation Trials Delivering 70 to 90 Gy. Journal of Clinical Oncology 35:13, pages 1387-1394.
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Laura K. McNew, Stephen R. Bowen, Olga Gopan, Matthew J. Nyflot, Shilpen A. Patel, Jing Zeng & Ramesh Rengan. (2017) The relationship between cardiac radiation dose and mediastinal lymph node involvement in stage III non-small cell lung cancer patients. Advances in Radiation Oncology 2:2, pages 192-196.
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Hann-Hsiang Chao, Abigail T. Berman, Charles B. SimoneIIII, Christine Ciunci, Peter Gabriel, Haibo Lin, Stefan Both, Corey Langer, Kristi Lelionis, Ramesh Rengan, Stephen M. Hahn, Kiran Prabhu, Marcio Fagundes, William Hartsell, Rosemarie Mick & John P. Plastaras. (2017) Multi-Institutional Prospective Study of Reirradiation with Proton Beam Radiotherapy for Locoregionally Recurrent Non–Small Cell Lung Cancer. Journal of Thoracic Oncology 12:2, pages 281-292.
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Xin Ming, Yuanming Feng, Chengwen Yang, Wei Wang, Ping Wang & Jun Deng. (2016) Radiation-induced heart disease in lung cancer radiotherapy. Medicine 95:41, pages e5051.
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Michael T. Milano, Lawrence B. Marks & Louis S. Constine. 2016. Clinical Radiation Oncology. Clinical Radiation Oncology 253 274.e6 .
Xin Ming, Yuanming Feng, Huan Liu, Ying Zhang, Li Zhou & Jun Deng. (2015) Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer. PLOS ONE 10:12, pages e0144211.
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Vieri Scotti, Calogero Saieva, Vanessa Di Cataldo, Alessio Bruni, Isacco Desideri, Silvia Bertocci, Icro Meattini, Lorenzo Livi, Gabriele Simontacchi, Carla De Luca Cardillo, Benedetta Bendinelli, Paolo Bastiani, Monica Mangoni, Benedetta Agresti & Giampaolo Biti. (2018) Vinorelbine-Based Chemo-Radiotherapy in Non-Small Cell Lung Cancer. Tumori Journal 98:4, pages 464-470.
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Tine B. Nielsen, Elinore Wieslander, Antonella Fogliata, Morten Nielsen, Olfred Hansen & Carsten Brink. (2011) Influence of dose calculation algorithms on the predicted dose distributions and NTCP values for NSCLC patients. Medical Physics 38:5, pages 2412-2418.
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