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Original Articles

Both macrophages and hypoxia play critical role in regulating invasion of gastric cancer in vitro

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Pages 852-860 | Received 08 Oct 2012, Accepted 19 Jun 2012, Published online: 29 Nov 2012

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Debora Basile, Francesca Simionato, Lorenzo Calvetti, Alessandro Cappetta, Annalisa Pesavento, Marta Mongillo, Giandomenico Roviello, Gerardo Rosati, Gemma Rossi & Giuseppe Aprile. (2021) Comparing immunotherapies to other frequently used treatments of gastric cancer. Expert Review of Clinical Pharmacology 14:10, pages 1221-1232.
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Chao Wu, Meng-hua Zeng, Gang Liao, Kun Qian & Hui Li. (2020) Neuropilin-1 Interacts with Fibronectin-1 to Promote Epithelial–Mesenchymal Transition Progress in Gastric Cancer. OncoTargets and Therapy 13, pages 10677-10687.
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Mette Winther, Jan Alsner, Trine Tramm & Marianne Nordsmark. (2013) Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer. Acta Oncologica 52:7, pages 1327-1335.
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Articles from other publishers (25)

Yue Shen, Jia-Xi Chen, Ming Li, Ze Xiang, Jian Wu & Yi-Jin Wang. (2023) Role of tumor-associated macrophages in common digestive system malignant tumors. World Journal of Gastrointestinal Oncology 15:4, pages 596-616.
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Aviva Atri-Schuller, Hassan Abushukair, Ludimila Cavalcante, Stijn Hentzen, Azhar Saeed & Anwaar Saeed. (2022) Tumor Molecular and Microenvironment Characteristics in EBV-Associated Malignancies as Potential Therapeutic Targets: Focus on Gastric Cancer. Current Issues in Molecular Biology 44:11, pages 5756-5767.
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Alessandro Agnarelli, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos & Georgios Giamas. (2022) Incorporating Immunotherapy in the Management of Gastric Cancer: Molecular and Clinical Implications. Cancers 14:18, pages 4378.
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Cemre Ucaryilmaz Metin & Gulnihal Ozcan. (2022) The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer. Cancers 14:11, pages 2711.
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Matilda Juusola, Krista Kuuliala, Antti Kuuliala, Harri Mustonen, Markus Vähä-Koskela, Pauli Puolakkainen & Hanna Seppänen. (2021) Pancreatic cancer is associated with aberrant monocyte function and successive differentiation into macrophages with inferior anti-tumour characteristics. Pancreatology 21:2, pages 397-405.
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V. Gambardella, J. Castillo, N. Tarazona, F. Gimeno-Valiente, C. Martínez-Ciarpaglini, M. Cabeza-Segura, S. Roselló, D. Roda, M. Huerta, A. Cervantes & T. Fleitas. (2020) The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target. Cancer Treatment Reviews 86, pages 102015.
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Fei Ma, Bin Zhang, Sheqing Ji, Hongtao Hu, Ye Kong, Yawei Hua & Suxia Luo. (2019) Hypoxic Macrophage-Derived VEGF Promotes Proliferation and Invasion of Gastric Cancer Cells. Digestive Diseases and Sciences 64:11, pages 3154-3163.
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Yutong Gao, Xiangdi Yu, Fangxiang Zhang & Jing Dai. (2019) Propofol inhibits pancreatic cancer progress under hypoxia via ADAM 8 . Journal of Hepato-Biliary-Pancreatic Sciences 26:6, pages 219-226.
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Catharina Conrad, Julia Benzel, Kristina Dorzweiler, Lena Cook, Uwe Schlomann, Alexander Zarbock, Emily P. Slater, Christopher Nimsky & Jörg W. Bartsch. (2019) ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance. Clinical Science 133:1, pages 83-99.
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Ana Rita Nobre, David Entenberg, Yarong Wang, John Condeelis & Julio A. Aguirre-Ghiso. (2018) The Different Routes to Metastasis via Hypoxia-Regulated Programs. Trends in Cell Biology 28:11, pages 941-956.
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Meri R. Räihä & Pauli A. Puolakkainen. (2018) Tumor‐associated macrophages (TAMs) as biomarkers for gastric cancer: A review. Chronic Diseases and Translational Medicine 4:3, pages 156-163.
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Aino Salmiheimo, Harri Mustonen, Sanna Vainionpää, Zhanlong Shen, Esko Kemppainen, Pauli Puolakkainen & Hanna Seppänen. (2017) Tumour-associated macrophages activate migration and STAT3 in pancreatic ductal adenocarcinoma cells in co-cultures. Pancreatology 17:4, pages 635-641.
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Pu Xia & Xiao-Yan Xu. (2017) Epithelial–mesenchymal transition and gastric cancer stem cell. Tumor Biology 39:5, pages 101042831769837.
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Arunima ShilpiYingtao BiSegun JungSamir K. PatraRamana V. Davuluri. (2017) Identification of Genetic and Epigenetic Variants Associated with Breast Cancer Prognosis by Integrative Bioinformatics Analysis. Cancer Informatics 16, pages CIN.S39783.
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Alexei Gratchev. (2017) TGF-β signalling in tumour associated macrophages. Immunobiology 222:1, pages 75-81.
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Ying Wang, Tao Liu, Ning Yang, Shuo Xu, Xingang Li & Donghai Wang. (2016) Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis. Oncology Reports.
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Xuming Zhou, Xuehong Meng, Zhijin Liu, Jiang Chang, Boshi Wang, Mingzhou Li, Pablo Orozco-ter Wengel, Shilin Tian, Changlong Wen, Ziming Wang, Paul A Garber, Huijuan Pan, Xinping Ye, Zuofu Xiang, Michael W. Bruford, Scott V. Edwards, Yinchuan Cao, Shuancang Yu, Lianju Gao, Zhisheng Cao, Guangjian Liu, Baoping Ren, Fanglei Shi, Zalan Peterfi, Dayong Li, Baoguo Li, Zhi Jiang, Junsheng Li, Vadim N. Gladyshev, Ruiqiang Li & Ming Li. (2016) Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. Molecular Biology and Evolution 33:10, pages 2670-2681.
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Qian Zhang, Wenyu Gou, Xiaotong Wang, Yawen Zhang, Jun Ma, Hongliang Zhang, Ying Zhang & Hao Zhang. (2016) Genome Resequencing Identifies Unique Adaptations of Tibetan Chickens to Hypoxia and High-Dose Ultraviolet Radiation in High-Altitude Environments. Genome Biology and Evolution 8:3, pages 765-776.
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Jinbao Guo, Bin Wang, Zhongxue Fu, Jinlai Wei & Weidong Lu. (2015) Hypoxic Microenvironment Induces EMT and Upgrades Stem-Like Properties of Gastric Cancer Cells. Technology in Cancer Research & Treatment 15:1, pages 60-68.
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Hui-Ying Ma, Xin-Zhou Liu & Chun-Min Liang. (2016) Inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer. World Journal of Gastroenterology 22:29, pages 6619.
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Ana P. Cardoso, Marta L. Pinto, Ana T. Pinto, Marta T. Pinto, Cátia Monteiro, Marta I. Oliveira, Susana G. Santos, João B. Relvas, Raquel Seruca, Alberto Mantovani, Marc Mareel, Mário A. Barbosa & Maria J. Oliveira. (2015) Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour. BMC Cancer 15:1.
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Aiqin Sun, Guanzhen Yu, Xiaoyan Dou, Xiaowei Yan, Wannian Yang & Qiong Lin. (2014) Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis. Molecular Cancer 13:1.
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Robin Roychaudhuri, Anja H. Hergrueter, Francesca Polverino, Maria E. Laucho-Contreras, Kushagra Gupta, Niels Borregaard & Caroline A. Owen. (2014) ADAM9 Is a Novel Product of Polymorphonuclear Neutrophils: Regulation of Expression and Contributions to Extracellular Matrix Protein Degradation during Acute Lung Injury. The Journal of Immunology 193:5, pages 2469-2482.
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Hua Zhao, Yongjun Li, Shaobin Wang, Yadong Yang, Junyun Wang, Xiuyan Ruan, Yaran Yang, Kan Cai, Bing Zhang, Peng Cui, Jiangwei Yan, Yongliang Zhao, Edward K. Wakeland, Quanzhen Li, Songnian Hu & Xiangdong Fang. (2014) Whole transcriptome RNA-seq analysis: tumorigenesis and metastasis of melanoma. Gene 548:2, pages 234-243.
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Pauli Puolakkainen, Aino Koski, Sanna Vainionpää, Zhanlong Shen, Heikki Repo, Esko Kemppainen, Harri Mustonen & Hanna Seppänen. (2014) Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression. Medical Oncology 31:3.
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