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Radiotherapy

The QUANTEC criteria for parotid gland dose and their efficacy to prevent moderate to severe patient-rated xerostomia

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Pages 597-604 | Received 04 Jun 2013, Accepted 16 Jul 2013, Published online: 02 Sep 2013

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Megi Gjini, Sadia Ahmed, Shalom Kalnicki, Wolfgang A. Tomé, Madhur K. Garg, Rafi Kabarriti & N. Patrik Brodin. (2022) Volumetric changes of the parotid gland during IMRT based on mid-treatment imaging: implications for parotid stem cell sparing strategies in head and neck cancer. Acta Oncologica 61:9, pages 1069-1074.
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Hubert Szymon Gabryś, Florian Buettner, Florian Sterzing, Henrik Hauswald & Mark Bangert. (2017) Parotid gland mean dose as a xerostomia predictor in low-dose domains. Acta Oncologica 56:9, pages 1197-1203.
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Maria Najim, Lakmalie Perera, Louise Bendall, Jonathan R. Sykes, Val Gebski, Shamira Cross & Michael Veness. (2015) Volumetric and dosimetric changes to salivary glands during radiotherapy for head and neck cancer. Acta Oncologica 54:9, pages 1691-1693.
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Haley D. Clark, Vitali V. Moiseenko, Thomas P. Rackley, Steven D. Thomas, Jonn S. Wu & Stefan A. Reinsberg. (2015) Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation. Acta Oncologica 54:9, pages 1686-1690.
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Laura Tuomikoski, Mika Kapanen, Juhani Collan, Jani Keyriläinen, Kauko Saarilahti, Venla Loimu, Tiina Seppälä & Mikko Tenhunen. (2015) Toward a more patient-specific model of post-radiotherapy saliva secretion for head and neck cancer patients. Acta Oncologica 54:9, pages 1310-1316.
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Nigel J. Anderson, Morikatsu Wada, Michal Schneider-Kolsky, Maureen Rolfo, Daryl Lim Joon & Vincent Khoo. (2014) Dose-volume response in acute dysphagia toxicity: Validating QUANTEC recommendations into clinical practice for head and neck radiotherapy. Acta Oncologica 53:10, pages 1305-1311.
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Joseph O. Deasy & Ludvig P. Muren. (2014) Advancing our quantitative understanding of radiotherapy normal tissue morbidity. Acta Oncologica 53:5, pages 577-579.
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Susan Y. Wu & Sue S. Yom. 2020. Textbook of Oral Cancer. Textbook of Oral Cancer 303 309 .
Wilko F.A.R. Verbakel, Patricia A.H. Doornaert, Cornelis P.J. Raaijmakers, Luc J. Bos, Marion Essers, Jeroen B. van de Kamer, Max Dahele, Chris H.J. Terhaard & Johannes H.A.M. Kaanders. (2019) Targeted Intervention to Improve the Quality of Head and Neck Radiation Therapy Treatment Planning in the Netherlands: Short and Long-Term Impact. International Journal of Radiation Oncology*Biology*Physics 105:3, pages 514-524.
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Crossref
Siri Beier Jensen, Arjan Vissink, Kirsten H Limesand & Mary E Reyland. (2019) Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients. JNCI Monographs 2019:53.
Crossref
Frederik K L Spijkervet, Michael T Brennan, Douglas E Peterson, Max J H Witjes & Arjan Vissink. (2019) Research Frontiers in Oral Toxicities of Cancer Therapies: Osteoradionecrosis of the Jaws. JNCI Monographs 2019:53.
Crossref
Laura B. Moroney, Jennifer Helios, Elizabeth C. Ward, Jane Crombie, Clare L. Burns, Shu Qi Yeo, Anita Pelecanos, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Benjamin Chua & Brett G. M. Hughes. (2018) Radiotherapy for cutaneous head and neck cancer and parotid tumours: a prospective investigation of treatment-related acute swallowing and toxicity patterns. Supportive Care in Cancer 27:2, pages 573-581.
Crossref
N.Patrik Brodin & Wolfgang A. Tomé. (2018) Revisiting the dose constraints for head and neck OARs in the current era of IMRT. Oral Oncology 86, pages 8-18.
Crossref
Keyvan Moharamzadeh. 2018. Diseases and Conditions in Dentistry. Diseases and Conditions in Dentistry 307 312 .
Tae Jin Han. (2018) Radiotherapy in the Region of the Head and Neck and the Consequential Changes in Normal Tissues. Journal of the Korean Dysphagia Society 8:2, pages 57-66.
Crossref
Valerio Nardone, Paolo Tini, Christophe Nioche, Maria Antonietta Mazzei, Tommaso Carfagno, Giuseppe Battaglia, Pierpaolo Pastina, Roberta Grassi, Lucio Sebaste & Luigi Pirtoli. (2018) Texture analysis as a predictor of radiation-induced xerostomia in head and neck patients undergoing IMRT. La radiologia medica 123:6, pages 415-423.
Crossref
N. Patrik Brodin, Rafi Kabarriti, Madhur K. Garg, Chandan Guha & Wolfgang A. Tomé. (2018) Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports. International Journal of Radiation Oncology*Biology*Physics 100:2, pages 391-407.
Crossref
楠 王. (2018) Current Methods to Reduce or Salvage Radiation Damage to Salivary Glands. World Journal of Cancer Research 08:03, pages 121-125.
Crossref
Peter G. Hawkins, Jae Y. Lee, Yanping Mao, Pin Li, Michael Green, Francis P. Worden, Paul L. Swiecicki, Michelle L. Mierzwa, Matthew E. Spector, Matthew J. Schipper & Avraham Eisbruch. (2018) Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life. Radiotherapy and Oncology 126:1, pages 68-74.
Crossref
Christopher D. Frisch, Beth M. Beadle & Paul W. Gidley. 2018. Temporal Bone Cancer. Temporal Bone Cancer 379 402 .
Adepitan A. Owosho, Maria Thor, Jung Hun Oh, Nadeem Riaz, C. Jillian Tsai, Haley Rosenberg, Spyridon Varthis, Sae Hee K. Yom, Joseph M. Huryn, Nancy Y. Lee, Joseph O. Deasy & Cherry L. Estilo. (2017) The role of parotid gland irradiation in the development of severe hyposalivation (xerostomia) after intensity-modulated radiation therapy for head and neck cancer: Temporal patterns, risk factors, and testing the QUANTEC guidelines. Journal of Cranio-Maxillofacial Surgery 45:4, pages 595-600.
Crossref
Alan C. Hartford, Thomas H. Davis, Jay C. Buckey, Robert L. Foote, Mark S. Sinesi, Benjamin B. Williams, Anna K. Fariss, Philip E. Schaner, Paul L. Claus, Scott H. Okuno, James R. Hussey & Richard E. Clarke. (2017) Hyperbaric Oxygen as Radiation Sensitizer for Locally Advanced Squamous Cell Carcinoma of the Oropharynx: A Phase 1 Dose-Escalation Study. International Journal of Radiation Oncology*Biology*Physics 97:3, pages 481-486.
Crossref
Maria Thor, Adepitan A. Owosho, Haley D. Clark, Jung Hun Oh, Nadeem Riaz, Allan Hovan, Jillian Tsai, Steven D. Thomas, Sae Hee K. Yom, Jonn S. Wu, Joseph M. Huryn, Vitali Moiseenko, Nancy Y. Lee, Cherry L. Estilo & Joseph O. Deasy. (2017) Internal and external generalizability of temporal dose–response relationships for xerostomia following IMRT for head and neck cancer. Radiotherapy and Oncology 122:2, pages 200-206.
Crossref
Venla Loimu, Tiina Seppälä, Mika Kapanen, Laura Tuomikoski, Heidi Nurmi, Antti Mäkitie, Mikko Tenhunen & Kauko Saarilahti. (2017) Diffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy. Radiotherapy and Oncology 122:2, pages 178-184.
Crossref
Carly Barbon, Andrew Hope & Catriona Steele. (2017) Radiation 101: A Guide for Speech-Language Pathologists. Perspectives of the ASHA Special Interest Groups 2:13, pages 63-72.
Crossref
Anna Vives-Soler, Jos? L?pez-L?pez & Enric Jan?-Salas. (2017) Xerostom?a y radioterapia de cabeza y cuello: actualizaci?n. Revista Colombiana de Cancerolog?a 21:1, pages 26-32.
Crossref
Dewi Borkent & Keyvan Moharamzadeh. 2017. Biomaterials for Oral and Dental Tissue Engineering. Biomaterials for Oral and Dental Tissue Engineering 337 351 .
Isabelle M. A. Lombaert. 2017. Salivary Gland Development and Regeneration. Salivary Gland Development and Regeneration 3 22 .
J. Castelli, A. Simon, B. Rigaud, C. Lafond, E. Chajon, J. D. Ospina, P. Haigron, B. Laguerre, A. Ruffier Loubière, K. Benezery & R. de Crevoisier. (2016) A Nomogram to predict parotid gland overdose in head and neck IMRT. Radiation Oncology 11:1.
Crossref
Adepitan A. Owosho, SaeHee K. Yom, Zhiqiang Han, Kevin Sine, Nancy Y. Lee, Joseph M. Huryn & Cherry L. Estilo. (2016) Comparison of mean radiation dose and dosimetric distribution to tooth-bearing regions of the mandible associated with proton beam radiation therapy and intensity-modulated radiation therapy for ipsilateral head and neck tumor. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 122:5, pages 566-571.
Crossref
Martin T. King, Leslie Modlin, Lynn Million, Sarah S. Donaldson, Iris C. Gibbs, Clara Y. H. Choi & Scott G. Soltys. (2015) The Parotid Gland is an Underrecognized Organ at Risk for Craniospinal Irradiation. Technology in Cancer Research & Treatment 15:3, pages 472-479.
Crossref
Yitzhak Marmary, Revital Adar, Svetlana Gaska, Annette Wygoda, Alexander Maly, Jonathan Cohen, Ron Eliashar, Lina Mizrachi, Carmit Orfaig-Geva, Bruce J. Baum, Stefan Rose-John, Eithan Galun & Jonathan H. Axelrod. (2016) Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation. Cancer Research 76:5, pages 1170-1180.
Crossref
Timothy Dale, Katherine Hutcheson, Abdallah S.R. Mohamed, Jan S. Lewin, G. Brandon Gunn, Arvind U.K. Rao, Jayashree Kalpathy-Cramer, Steven J. Frank, Adam S. Garden, Jay A. Messer, Benjamin Warren, Stephen Y. Lai, Beth M. Beadle, William H. Morrison, Jack Phan, Heath Skinner, Neil Gross, Renata Ferrarotto, Randal S. Weber, David I. Rosenthal & Clifton D. Fuller. (2016) Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: Dose?volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy. Radiotherapy and Oncology 118:2, pages 304-314.
Crossref
Miranda E.M.C. Christianen, Irma M. Verdonck-de Leeuw, Patricia Doornaert, Olga Chouvalova, Roel J.H.M. Steenbakkers, Phil W. Koken, C. René Leemans, Sjoukje F. Oosting, Jan L.N. Roodenburg, Bernard F.A.M. van der Laan, Ben J. Slotman, Hendrik P. Bijl & Johannes A. Langendijk. (2015) Patterns of long-term swallowing dysfunction after definitive radiotherapy or chemoradiation. Radiotherapy and Oncology 117:1, pages 139-144.
Crossref
Tsair-Fwu Lee, Ming-Hsiang Liou, Hui-Min Ting, Liyun Chang, Hsiao-Yi Lee, Stephen Wan Leung, Chih-Jen Huang & Pei-Ju Chao. (2015) Patient- and therapy-related factors associated with the incidence of xerostomia in nasopharyngeal carcinoma patients receiving parotid-sparing helical tomotherapy. Scientific Reports 5:1.
Crossref
Maria Luisa Belli, Sara Broggi, Elisa Scalco, Giovanni Mauro Cattaneo, Italo Dell'Oca, Gerlinde Logghe, Stefano Moriconi, Giuseppe Sanguineti, Vincenzo Valentini, Nadia Di Muzio, Claudio Fiorino & Riccardo Calandrino. (2015) Analysis of serial CT images for studying the RT effects in head-neck cancer patients. Analysis of serial CT images for studying the RT effects in head-neck cancer patients.
Toru Shibata. 2015. Intensity-Modulated Radiation Therapy. Intensity-Modulated Radiation Therapy 59 84 .
Tsair-Fwu Lee, Ming-Hsiang Liou, Yu-Jie Huang, Pei-Ju Chao, Hui-Min Ting, Hsiao-Yi Lee & Fu-Min Fang. (2014) LASSO NTCP predictors for the incidence of xerostomia in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma. Scientific Reports 4:1.
Crossref

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