Advanced search
Publication Cover
Connective Tissue Research Volume 52, 2011 - Issue 2
Submit an article Journal homepage
323
Views
42
CrossRef citations to date
0
Altmetric
Research Article

Adipose-derived stem cells and BMP2: Part 1. BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects

Yu-Fen Chou Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, California, USA
,
Patricia A. Zuk Regenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USACorrespondence[email protected]
,
Ting-Ling Chang Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, University of California, Los Angeles, California, USA
,
Prosper Benhaim Regenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
&
Benjamin M. Wu Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, California, USA; Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, University of California, Los Angeles, California, USA
Pages 109-118 | Received 25 Nov 2009, Accepted 01 Mar 2010, Published online: 11 Aug 2010

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Marta Barba, Giuseppe Di Taranto & Wanda Lattanzi. (2017) Adipose-derived stem cell therapies for bone regeneration. Expert Opinion on Biological Therapy 17:6, pages 677-689.
Read now
Xinlin Yang, Ching-Ju Li, Yueping Wan, Pinar Smith, Guowei Shang & Quanjun Cui. (2014) Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells. International Journal of Nanomedicine 9, pages 4023-4031.
Read now

Articles from other publishers (40)

Ni Su, Cassandra Villicana & Fan Yang. (2022) Immunomodulatory strategies for bone regeneration: A review from the perspective of disease types. Biomaterials 286, pages 121604.
Crossref
Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe & Quanjun Cui. (2021) Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection. World Journal of Stem Cells 13:9, pages 1248-1277.
Crossref
Elena Calciolari, Aliye Akcalı & Nikolaos Donos. 2020. Bone Augmentation by Anatomical Region. Bone Augmentation by Anatomical Region 69 93 .
Muhammad Qasim, Dong Sik Chae & Nae Yoon Lee. (2019) Bioengineering strategies for bone and cartilage tissue regeneration using growth factors and stem cells. Journal of Biomedical Materials Research Part A 108:3, pages 394-411.
Crossref
Dan WangJames R. GilbertXu ZhangBingkun ZhaoDai Fei Elmer KerGregory M. Cooper. (2020) Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering. Tissue Engineering Part B: Reviews 26:1, pages 46-63.
Crossref
Mark Bartold, Stan Gronthos, David Haynes & Saso Ivanovski. (2019) Mesenchymal stem cells and biologic factors leading to bone formation. Journal of Clinical Periodontology 46, pages 12-32.
Crossref
Saeid Kargozar, Masoud Mozafari, Sepideh Hamzehlou, Peiman Brouki Milan, Hae-Won Kim & Francesco Baino. (2019) Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations. Applied Sciences 9:1, pages 174.
Crossref
Sébastien B.G. Blanquer, Arjen W.H. Gebraad, Susanna Miettinen, André A. Poot, Dirk W. Grijpma & Suvi P. Haimi. (2017) Differentiation of adipose stem cells seeded towards annulus fibrosus cells on a designed poly(trimethylene carbonate) scaffold prepared by stereolithography. Journal of Tissue Engineering and Regenerative Medicine 11:10, pages 2752-2762.
Crossref
Mathieu Maisani, Daniele Pezzoli, Olivier Chassande & Diego Mantovani. (2017) Cellularizing hydrogel-based scaffolds to repair bone tissue: How to create a physiologically relevant micro-environment?. Journal of Tissue Engineering 8, pages 204173141771207.
Crossref
Nasim Salehi-Nik, Maryam Rezai Rad, Lida Kheiri, Pantea Nazeman, Nasser Nadjmi & Arash Khojasteh. (2017) Buccal Fat Pad as a Potential Source of Stem Cells for Bone Regeneration: A Literature Review. Stem Cells International 2017, pages 1-13.
Crossref
Yahya Açil, Amir Alexander Ghoniem, Aydin Gülses, Tobias Kisch, Felix Stang, Jörg Wiltfang & Matthias Gierloff. (2017) Suppression of osteoblast-related genes during osteogenic differentiation of adipose tissue derived stromal cells. Journal of Cranio-Maxillofacial Surgery 45:1, pages 33-38.
Crossref
Gabriela Fernandes & Shuying Yang. (2016) Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering. Bone Research 4:1.
Crossref
T Genova, L Munaron, S Carossa & F Mussano. (2015) Overcoming physical constraints in bone engineering: ‘the importance of being vascularized’. Journal of Biomaterials Applications 30:7, pages 940-951.
Crossref
Sari Vanhatupa, Miina Ojansivu, Reija Autio, Miia Juntunen & Susanna Miettinen. (2015) Bone Morphogenetic Protein-2 Induces Donor-Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells. Stem Cells Translational Medicine 4:12, pages 1391-1402.
Crossref
Xiao Zhang, Jing Guo, Gang Wu & Yongsheng Zhou. (2015) Effects of heterodimeric bone morphogenetic protein-2/7 on osteogenesis of human adipose-derived stem cells. Cell Proliferation 48:6, pages 650-660.
Crossref
Vedavathi Madhu, Allison Kilanski, Nikitha Reghu, Abhijit S. Dighe & Quanjun Cui. (2015) Expression of CD105 and CD34 receptors controls BMP-induced in vitro mineralization of mouse adipose-derived stem cells but does not predict their in vivo bone-forming potential. Journal of Orthopaedic Research 33:5, pages 625-632.
Crossref
Satoshi TajimaMorikuni TobitaHakan OrbayHiko HyakusokuHiroshi Mizuno. (2015) Direct and Indirect Effects of a Combination of Adipose-Derived Stem Cells and Platelet-Rich Plasma on Bone Regeneration. Tissue Engineering Part A 21:5-6, pages 895-905.
Crossref
Jinling Ma, Fang Yang, Sanne K. Both, Henk-Jan Prins, Marco N. Helder, Juli Pan, Fu-Zhai Cui, John A. Jansen & Jeroen J.J.P. van den Beucken. (2015) Bone forming capacity of cell- and growth factor-based constructs at different ectopic implantation sites. Journal of Biomedical Materials Research Part A 103:2, pages 439-450.
Crossref
Anisa Yalom, Akishige Hokugo, Sarah Sorice, Andrew Li, Luis A. Segovia Aguilar, Patricia Zuk & Reza Jarrahy. (2014) In Vitro Osteoinductive Effects of Hydroxycholesterol on Human Adipose-Derived Stem Cells Are Mediated through the Hedgehog Signaling Pathway. Plastic and Reconstructive Surgery 134:5, pages 960-968.
Crossref
Alessia Ongaro, Agnese Pellati, Leila Bagheri, Cinzia Fortini, Stefania Setti & Monica De Mattei. (2014) Pulsed electromagnetic fields stimulate osteogenic differentiation in human bone marrow and adipose tissue derived mesenchymal stem cells. Bioelectromagnetics 35:6, pages 426-436.
Crossref
Rajendra Aryal, Xiao-peng Chen, Cheng Fang & Yong-cheng Hu. (2014) Bone Morphogenetic Protein-2 and Vascular Endothelial Growth Factor in Bone Tissue Regeneration: New Insight and Perspectives. Orthopaedic Surgery 6:3, pages 171-178.
Crossref
Jiabing FanHyejin ParkMatthew K. LeeOlga BezouglaiaArmita FartashJinku KimTara AghalooMin Lee. (2014) Adipose-Derived Stem Cells and BMP-2 Delivery in Chitosan-Based 3D Constructs to Enhance Bone Regeneration in a Rat Mandibular Defect Model. Tissue Engineering Part A 20:15-16, pages 2169-2179.
Crossref
Vedavathi Madhu, Ching-Ju Li, Abhijit S. Dighe, Gary Balian & Quanjun Cui. (2014) BMP-Non-Responsive Sca1+CD73+CD44+ Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation. PLoS ONE 9:7, pages e103060.
Crossref
Kshemendra Senarath-Yapa, Adrian McArdle, Andrea Renda, Michael Longaker & Natalina Quarto. (2014) Adipose-Derived Stem Cells: A Review of Signaling Networks Governing Cell Fate and Regenerative Potential in the Context of Craniofacial and Long Bone Skeletal Repair. International Journal of Molecular Sciences 15:6, pages 9314-9330.
Crossref
Chin-Yu LinYu-Han ChangLi-Yu SungChiu-Ling ChenShih-Yeh LinKuei-Chang LiTzu-Chen YenKun-Ju LinYu-Chen Hu. (2014) Long-Term Tracking of Segmental Bone Healing Mediated by Genetically Engineered Adipose-Derived Stem Cells: Focuses on Bone Remodeling and Potential Side Effects. Tissue Engineering Part A 20:9-10, pages 1392-1402.
Crossref
Jinling Ma, Sanne K. Both, Wei Ji, Fang Yang, Henk‐Jan Prins, Marco N. Helder, Juli Pan, Fu‐Zhai Cui, John A. Jansen & Jeroen J. P. van den Beucken. (2013) Adipose tissue‐derived mesenchymal stem cells as monocultures or cocultures with human umbilical vein endothelial cells: Performance in vitro and in rat cranial defects . Journal of Biomedical Materials Research Part A 102:4, pages 1026-1036.
Crossref
M. Ruetze & W. Richter. (2014) Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity. Expert Reviews in Molecular Medicine 16.
Crossref
Guang-Wen Fang, Xin-Shuang Liu, Ting-Zhuo Lv, Heng-Sheng Shu & Heng Shao. (2013) A new choice for the treatment of segmental tibial bone defects: Intramedullary nail internal fixation combined adipose-derived stem cells technique. Medical Hypotheses 80:4, pages 422-424.
Crossref
Patricia Zuk. (2013) Adipose-Derived Stem Cells in Tissue Regeneration: A Review. ISRN Stem Cells 2013, pages 1-35.
Crossref
Marta Barba, Claudia Cicione, Camilla Bernardini, Fabrizio Michetti & Wanda Lattanzi. (2013) Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art. BioMed Research International 2013, pages 1-11.
Crossref
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon & Cláudia Maria Oliveira Simões. (2012) Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells. Journal of Applied Oral Science 20:6, pages 628-635.
Crossref
Martin Waselau, Mimmi Patrikoski, Miia Juntunen, Kasperi Kujala, Minna Kääriäinen, Hannu Kuokkanen, George K Sándor, Outi Vapaavuori, Riitta Suuronen, Bettina Mannerström, Brigitte von Rechenberg & Susanna Miettinen. (2012) Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells. Journal of Tissue Engineering 3:1, pages 204173141246778.
Crossref
Darren M. Smith, James J. Cray, Lee E. Weiss, Elmer K. Dai Fei, Sameer Shakir, S. Alex Rottgers, Joseph E. Losee, Philip G. Campbell & Gregory M. Cooper. (2012) Precise Control of Osteogenesis for Craniofacial Defect Repair. Annals of Plastic Surgery 69:4, pages 485-488.
Crossref
T. Shiraishi, Y. Sumita, Y. Wakamastu, K. Nagai & I. Asahina. (2012) Formation of Engineered Bone with Adipose Stromal Cells from Buccal Fat Pad. Journal of Dental Research 91:6, pages 592-597.
Crossref
Chin-Yu Lin, Yu-Han Chang, Chun-Yu Kao, Chia-Hsin Lu, Li-Yu Sung, Tzu-Chen Yen, Kun-Ju Lin & Yu-Chen Hu. (2012) Augmented healing of critical-size calvarial defects by baculovirus-engineered MSCs that persistently express growth factors. Biomaterials 33:14, pages 3682-3692.
Crossref
Gabriela Ciapetti, Donatella Granchi, Valentina Devescovi, Serena R. Baglio, Elisa Leonardi, Desirèe Martini, Maria Jesus Jurado, Beatriz Olalde, Ilaria Armentano, Josè M. Kenny, Frank X. Walboomers, Josè Inaki Alava & Nicola Baldini. (2012) Enhancing Osteoconduction of PLLA-Based Nanocomposite Scaffolds for Bone Regeneration Using Different Biomimetic Signals to MSCs. International Journal of Molecular Sciences 13:2, pages 2439-2458.
Crossref
Eva Prosecká, Matej Buzgo, Michala Rampichová, Tomáš Kocourek, Petra Kochová, Lucie Vysloužilová, Daniel Tvrdík, Miroslav Jelínek, David Lukáš & Evžen Amler. (2012) Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts. Journal of Biomedicine and Biotechnology 2012, pages 1-10.
Crossref
Saleh Heneidi & Gregorio Chazenbalk. 2012. Stem Cells and Human Diseases. Stem Cells and Human Diseases 323 351 .
Chin-Yu Lin, Kun-Ju Lin, Chun-Yu Kao, Mu-Cheng Chen, Wen-Hsin Lo, Tzu-Chen Yen, Yu-Han Chang & Yu-Chen Hu. (2011) The role of adipose-derived stem cells engineered with the persistently expressing hybrid baculovirus in the healing of massive bone defects. Biomaterials 32:27, pages 6505-6514.
Crossref
Anusuya Ramasubramanian, Stacey Shiigi, Gordon K. Lee & Fan Yang. (2011) Non-viral Delivery of Inductive and Suppressive Genes to Adipose-Derived Stem Cells for Osteogenic Differentiation. Pharmaceutical Research 28:6, pages 1328-1337.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.