Advanced search
Publication Cover
Connective Tissue Research Volume 3, 1975 - Issue 2-3
Submit an article Journal homepage
25
Views
65
CrossRef citations to date
0
Altmetric
Original Article

Stimulation of Chondroitin Sulfate Proteoglycan Production by Chondrocytes in Monolayer

Nancy B. Schwartz Department of Pediatrics, Joseph P. Kennedy, Jr., Mental Retardation Research Center, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, 60637; Department of Biochemistry, Joseph P. Kennedy, Jr., Mental Retardation Research Center, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, 60637; Established Investigator of the American Heart Association
&
Albert Dorfman Department of Pediatrics, Joseph P. Kennedy, Jr., Mental Retardation Research Center, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, 60637; Department of Biochemistry, Joseph P. Kennedy, Jr., Mental Retardation Research Center, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, 60637
Pages 115-122 | Received 20 Sep 1974, Accepted 29 Oct 1974, Published online: 07 Jul 2009

Citations (65)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Priyanka Dwivedi, Sumrita Bhat, Vijayashree Nayak & Ashok Kumar. (2014) Study of Different Delivery Modes of Chondroitin Sulfate Using Microspheres and Cryogel Scaffold for Application in Cartilage Tissue Engineering. International Journal of Polymeric Materials and Polymeric Biomaterials 63:16, pages 859-872.
Read now
Hyunji Lee, Hyeon-Son Choi, Yooheon Park, Chang Won Ahn, Sung Ug Jung, Soo Hyun Park & Hyung Joo Suh. (2014) Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats. Bioscience, Biotechnology, and Biochemistry 78:10, pages 1703-1709.
Read now
Talia Weinstein, Zoharia Evron, Meirav Trebicz-Geffen, Moran Aviv, Dror Robinson, Yehuda Kollander & Zvi Nevo. (2012) β-d-Xylosides Stimulate GAG Synthesis in Chondrocyte Cultures Due to Elevation of the Extracellular GAG Domains, Accompanied by the Depletion of the Intra–pericellular GAG Pools, with Alterations in the GAG Profiles. Connective Tissue Research 53:2, pages 169-179.
Read now
Peter C. Amadio, Michael G. Ehrlich & Henry J. Mankin. (1983) Matrix Synthesis in High Density Cultures of Bovine Epiphyseal Plate Chondrocytes. Connective Tissue Research 11:1, pages 11-19.
Read now
Kjell Madsen, Stefan Lohmander, Stanislaw Moskalewski & Aleksander Hinek. (1978) Proteoglycans Synthesized by Fetal Guinea Pig Chondrocytes in Culture. Connective Tissue Research 5:4, pages 205-210.
Read now
N. B. Schwartz. (1977) Regulation of Synthesis of Chondroitin Sulfate Proteoglycan. Upsala Journal of Medical Sciences 82:2, pages 76-77.
Read now

Articles from other publishers (59)

Bindia Sahu, Diya Deepak Sharma, Gladstone Christopher Jayakumar, Balaraman Madhan & Farhan Zameer. (2023) A review on an imperative by-product: Glycosaminoglycans- A holistic approach. Carbohydrate Polymer Technologies and Applications 5, pages 100275.
Crossref
Hyung Joo SuhHyunji LeeByung Jung MinSung Ug JungEun Young Jung. (2016) Effects of gangliosides from deer bone extract on the gene expressions of matrix metalloproteinases and collagen type II in interleukin-1β-induced osteoarthritic chondrocytes. Nutrition Research and Practice 10:6, pages 569.
Crossref
Priyanka Dwivedi, Vijayashree Nayak & Meenal Kowshik. (2015) Role of gold nanoparticles as drug delivery vehicles for chondroitin sulfate in the treatment of osteoarthritis. Biotechnology Progress 31:5, pages 1416-1422.
Crossref
. 2015. Bones and Cartilage. Bones and Cartilage 709 867 .
Hyunji LeeYooheon ParkChang Won AhnSoo Hyun ParkEun Young JungHyung Joo Suh. (2014) Deer Bone Extract Suppresses Articular Cartilage Damage Induced by Monosodium Iodoacetate in Osteoarthritic Rats: An In Vivo Micro–Computed Tomography Study . Journal of Medicinal Food 17:6, pages 701-706.
Crossref
S. Groeneboer, S. Lambrecht, A. Dhollander, P. Jacques, B. V. Cruyssen, R. J. Lories, K. Devreese, K. Chiers, D. Elewaut & G. Verbruggen. (2011) Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism. Rheumatology 50:7, pages 1226-1235.
Crossref
Yves Henrotin, Mariane Mathy, Christelle Sanchez & Cecile Lambert. (2010) Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations . Therapeutic Advances in Musculoskeletal Disease 2:6, pages 335-348.
Crossref
Sushmita Saha, Jennifer Kirkham, David Wood, Stephen Curran & Xuebin Yang. (2010) Comparative study of the chondrogenic potential of human bone marrow stromal cells, neonatal chondrocytes and adult chondrocytes. Biochemical and Biophysical Research Communications 401:3, pages 333-338.
Crossref
Mitsuhiko Kubo, Kosei Ando, Tomohiro Mimura, Yoshitaka Matsusue & Kanji Mori. (2009) Chondroitin sulfate for the treatment of hip and knee osteoarthritis: Current status and future trends. Life Sciences 85:13-14, pages 477-483.
Crossref
Liming Bian, Michael Kaplun, David Y. Williams, Duo Xu, Gerard A. Ateshian & Clark T. Hung. (2009) Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term culture. Journal of Biomechanics 42:3, pages 286-290.
Crossref
S. Groeneboer, P. Pastoureau, E. Vignon, B. Vander Cruyssen, D. Elewaut & G. Verbruggen. (2008) Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis. Osteoarthritis and Cartilage 16:9, pages 986-993.
Crossref
Nathaniel S. Hwang, Shyni Varghese, Christopher Puleo, Zijun Zhang & Jennifer Elisseeff. (2007) Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. Journal of Cellular Physiology 212:2, pages 281-284.
Crossref
G. Verbruggen. (2006) Chondroprotective drugs in degenerative joint diseases. Rheumatology 45:2, pages 129-138.
Crossref
Gust Verbruggen. 2006. Chondroitin Sulfate: Structure, Role and Pharmacological Activity. Chondroitin Sulfate: Structure, Role and Pharmacological Activity 491 505 .
Daniel Uebelhart, Ruud Knols, Eling D de Bruin & Gust Verbruggen. 2006. Chondroitin Sulfate: Structure, Role and Pharmacological Activity. Chondroitin Sulfate: Structure, Role and Pharmacological Activity 475 488 .
P. Verdonk, J. Wang, S. Groeneboer, C. Broddelez, D. Elewaut, E.M. Veys & G. Verbruggen. (2005) Cyclodextrin polysulphates repress IL-1 and promote the accumulation of chondrocyte extracellular matrix. Osteoarthritis and Cartilage 13:10, pages 887-895.
Crossref
. 2005. Bones and Cartilage. Bones and Cartilage 559 736 .
Wim J van Blitterswijk, Jos CM van de Nes & Paul IJM Wuisman. (2003) Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: Biochemical rationale and case report. BMC Complementary and Alternative Medicine 3:1.
Crossref
Jean-Pierre Bali, Henri Cousse & Eug?ne Neuzil. (2001) Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system. Seminars in Arthritis and Rheumatism 31:1, pages 58-68.
Crossref
E. Unger & U. J. Eriksson. (1992) Regionally disturbed production of cartilage proteoglycans in malformed fetuses from diabetic rats. Diabetologia 35:6, pages 517-521.
Crossref
Yngve Sommarin, Thomas Larsson & Dick Heinegård. (1989) Chondrocyte-matrix interactions. Experimental Cell Research 184:1, pages 181-192.
Crossref
S Collier & P Ghosh. (1989) Evaluation of the effect of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure.. Annals of the Rheumatic Diseases 48:5, pages 372-381.
Crossref
J.A. Cremata, A.J. N?n?ez, E. D?az, R. Le?n & L.M. Alfonso. (1988) Electron impact mass spectra of per-O-acetyl derivatives of 4?-substituted glycopyranosylphenylamines. Carbohydrate Research 180:1, pages 156-161.
Crossref
J. Terrig Thomas & Michael E. Grant. (1988) Cartilage proteoglycan aggregate and fibronectin can modulate the expression of type X collagen by embryonic chick chondrocytes cultured in collagen gels. Bioscience Reports 8:2, pages 163-171.
Crossref
Dean Kravis & William B. Upholt. (1985) Quantitation of type II procollagen mRNA levels during chick limb cartilage differentiation. Developmental Biology 108:1, pages 164-172.
Crossref
S. Vethamany‐Globus, M. Globus, A. Darch, G. Milton & B. L. Tomlinson. (2005) In vitro effects of insulin on macromolecular events in newt limb regeneration blastemata. Journal of Experimental Zoology 231:1, pages 63-74.
Crossref
M Geetha-Habib, S C Campbell & N B Schwartz. (1984) Subcellular localization of the synthesis and glycosylation of chondroitin sulfate proteoglycan core protein.. Journal of Biological Chemistry 259:11, pages 7300-7310.
Crossref
Beatrice Y.J.T. Yue, Charles C.L. Lin, P.F. Fei & Mark O.M. Tso. (1984) Effects of chondroitin sulfate on metabolism of trabecular meshwork. Experimental Eye Research 38:1, pages 35-44.
Crossref
Robert A. Kosher. 1983. Cartilage. Cartilage 59 85 .
H. Greiling, A. Gressner & K. Kleesiek. 1983. Rheumatologie A. Rheumatologie A 29 171 .
Paul J. La Rocca & Keen A. RaffertyJr.Jr.. (2005) Kinetics of chick embryo cell types in culture. Journal of Cellular Physiology 113:2, pages 203-210.
Crossref
Joanne M. Marsh, David W. Roback & Garry T. Ross. (1982) In vitro conditions affecting the synthesis of sulfated proteoglycans by normal and rheumatoid synovial cells in culture. Arthritis & Rheumatism 25:2, pages 196-203.
Crossref
Charles J. Malemud & Roland W. Moskowitz. (1981) Physiology of Articular Cartilage. Clinics in Rheumatic Diseases 7:1, pages 29-55.
Crossref
T.O. Kleine. 1981. 27 98 .
Albert Dorfman. 1988. Cell Biology of Extracellular Matrix. Cell Biology of Extracellular Matrix 115 138 .
Elisabeth Deudon, Monique Breton, Eliane Berrou & Jacques Picard. (1980) Metabolism of glycosaminoglycans in cultured smooth muscle cells from pig aorta. Biochimie 62:11-12, pages 811-821.
Crossref
Mark A. Nathanson & Elizabeth D. Hay. (1980) Analysis of cartilage differentiation from skeletal muscle grown on bone matrix. Developmental Biology 78:2, pages 332-351.
Crossref
Z. Nevo & Z. Laron. (1980) Hormonal and local agents as extracellular regulators of cartilage growth measured by the rate of proteoglycan synthesis. A hypothesis. Medical Hypotheses 6:4, pages 431-436.
Crossref
J.J. Kim & H.E. Conrad. (1980) Secretion of chondroitin SO4 by monolayer cultures of chick embryo chondrocytes.. Journal of Biological Chemistry 255:4, pages 1586-1597.
Crossref
Yukio Kato, Norimitsu Nasu, Toshiyuki Takase, Yasushi Daikuhara & Fujio Suzuki. (1980) A serum-free medium supplemented with multiplication-stimulating activity (MSA) supports both proliferation and differentiation of chondrocytes in primary culture. Experimental Cell Research 125:1, pages 167-174.
Crossref
G. Verbruggen, E. M. Veys, F. P. Luyten & S. Suykens. 1981. Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment 183 191 .
Diane A. Blake & H. Edward Conrad. (2002) Hybrid glycosaminoglycans synthesized by monolayers of chick embryo arterial fibroblasts. Biochemistry 18:24, pages 5475-5482.
Crossref
K. Stearns & P. F. Goetinck. (2005) Stimulation of chondroitin sulfate synthesis by β‐D‐xyloside in chondrocytes of the proteoglycan deficient mutant nanomelia. Journal of Cellular Physiology 100:1, pages 33-38.
Crossref
J.H. Glaser & H.E. Conrad. (1979) Chondroitin SO4 catabolism in chick embryo chondrocytes. Journal of Biological Chemistry 254:7, pages 2316-2325.
Crossref
N.B. Schwartz. (1979) Synthesis and secretion of an altered chondroitin sulfate proteoglycan. Journal of Biological Chemistry 254:7, pages 2271-2277.
Crossref
Robert A. Greenwald, Wai W. Moy & James Seibold. (1978) Functional properties of cartilage proteoglycans. Seminars in Arthritis and Rheumatism 8:1, pages 53-67.
Crossref
Zvi Nevo, Avivah Kowadlo Silbergeld & Mamet Rivka. (1978) The effect of normal human serum on proteoglycan synthesis. Biochimica et Biophysica Acta (BBA) - General Subjects 541:1, pages 76-83.
Crossref
. 1978. Developmental and Cellular Skeletal Biology. Developmental and Cellular Skeletal Biology 229 266 .
Barbara M. Vertel & Albert Dorfman. (1978) An immunohistochemical study of extracellular matrix formation during chondrogenesis. Developmental Biology 62:1, pages 1-12.
Crossref
A. M. Gressner, H. Pazen & H. Greiling. 1978. Aktuelle Probleme der Pathobiochemie. Aktuelle Probleme der Pathobiochemie 31 53 .
J.J. Kim & H.E. Conrad. (1977) Properties of cultured chondrocytes obtained from histologically distinct zones of the chick embryo tibiotarsus.. Journal of Biological Chemistry 252:22, pages 8292-8299.
Crossref
S. Handley & D.A. Lowther. (1977) Extracellular matrix metabolism by chondrocytes III. Modulation of proteoglycan synthesis by extracellular levels of proteoglycan in cartilage cells in culture. Biochimica et Biophysica Acta (BBA) - General Subjects 500:1, pages 132-139.
Crossref
K V John, N B Schwartz & H Ankel. (1977) UDP-glucuronate carboxy-lyase in cultured chondrocytes.. Journal of Biological Chemistry 252:19, pages 6707-6710.
Crossref
N B Schwartz. (1977) Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein.. Journal of Biological Chemistry 252:18, pages 6316-6321.
Crossref
Axel M. GRESSNER & Helmut GREILING. (1977) The Influence of Glycosaminoglycans on the Synthesis of Polyphenylalanine by Rat Liver Ribosomes. Hoppe-Seyler´s Zeitschrift für physiologische Chemie 358:1, pages 69-78.
Crossref
Nancy B. Schwartz, Pei-Lee Ho & Albert Dorfman. (1976) Effect of β-xylosides on synthesis of cartilage-specific proteoglycan in chondrocyte cultures. Biochemical and Biophysical Research Communications 71:3, pages 851-856.
Crossref
V C Hascall, T R Oegema & M Brown. (1976) Isolation and characterization of proteoglycans from chick limb bud chondrocytes grown in vitro.. Journal of Biological Chemistry 251:11, pages 3511-3519.
Crossref
N B Schwartz. (1976) Chondroitin sulfate glycosyltransferases in cultured chondrocytes. Turnover, oscillatory change during growth, and suppression by 5-bromodeoxyuridine.. Journal of Biological Chemistry 251:11, pages 3346-3351.
Crossref
Leon Sokoloff. (2006) Articular chondrocytes in culture. Matrix production and hormonal effects. Arthritis & Rheumatism 19:S3, pages 426-429.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.