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Research Article

History of Drug Metabolism: Discoveries of the Major Pathways in the 19th Century

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Pages 1-50 | Published online: 22 Sep 2008

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Read on this site (12)

Robert L. Smith & Stephen C. Mitchell. (2020) Pharmacogenetics and drug metabolism: historical perspective and appraisal. Xenobiotica 50:1, pages 3-8.
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Alan Wayne Jones. (2015) Profiles in drug metabolism and toxicology: Richard Tecwyn Williams (1909–1979). Drug Metabolism Reviews 47:4, pages 401-405.
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Christoffel Petrus Stephanus Badenhorst, Elardus Erasmus, Rencia van der Sluis, Carla Nortje & Alberdina Aike van Dijk. (2014) A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids. Drug Metabolism Reviews 46:3, pages 343-361.
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F. Peter Guengerich. (2004) Cytochrome P450: What Have We Learned and What Are the Future Issues?. Drug Metabolism Reviews 36:2, pages 159-197.
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Frederick J. Di Carlo, James D. Adams & Nadine Adams. (1992) Carl Paxson Sherwin, American Pioneer in Drug Metabolism. Drug Metabolism Reviews 24:4, pages 493-530.
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C. Bachmann & M. H. Bickel. (1985) History of Drug Metabolism: The First Half of the 20th Century. Drug Metabolism Reviews 16:3, pages 185-253.
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Peter G. Dayton & James E. Sanders. (1983) Dose-Dependent Pharmacokinetics: Emphasis on Phase I Metabolism. Drug Metabolism Reviews 14:3, pages 347-405.
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W. Robert Jondorf. (1981) Drug-metabolizing Enzymes as Evolutionary Probes. Drug Metabolism Reviews 12:2, pages 379-430.
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Marcel H. Bickel & Stefan Muehlebach. (1980) Pharmacokinetics and Ecodisposition of Polyhalogenated Hydrocarbons: Aspects and Concepts. Drug Metabolism Reviews 11:2, pages 149-190.
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Kenneth C. Leibman. (1979) Drug Metabolism: Prospects for the Future. Drug Metabolism Reviews 10:2, pages 299-309.
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R. Ploeger, A. Shugar, G.D. Smith & V.J. Chen. (2019) Late 19th century accounts of Indian yellow: The analysis of samples from the Royal Botanic Gardens, Kew. Dyes and Pigments 160, pages 418-431.
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Cindy Irwin, Lodewyk J. Mienie, Ron A. Wevers, Shayne Mason, Johan A. Westerhuis, Mari van Reenen & Carolus J. Reinecke. (2018) GC–MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption. Scientific Reports 8:1.
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Cindy Irwin, Mari van Reenen, Shayne Mason, Lodewyk J. Mienie, Johan A. Westerhuis & Carolus J. Reinecke. (2016) Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study. PLOS ONE 11:12, pages e0167309.
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Carla Nortje, Rencia van der Sluis, Alberdina Aike van Dijk & Elardus Erasmus. (2016) The Use of p -Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation . Journal of Biochemical and Molecular Toxicology 30:3, pages 136-147.
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James M. Schmidt. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 131 151 .
Carla Nortje, Peet Jansen van Rensburg, Cecile Cooke & Elardus Erasmus. (2015) The simultaneous detection and quantification of p-aminobenzoic acid and its phase 2 biotransformation metabolites in human urine using LC–MS/MS. Bioanalysis 7:10, pages 1211-1224.
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Hana Raoof, Przemyslaw Mielczarek, Katarzyna A. Michalow, Mieczyslaw Rekas & Jerzy Silberring. (2013) Synthesis of metabolites of paracetamol and cocaine via photooxidation on TiO2 catalyzed by UV light. Journal of Photochemistry and Photobiology B: Biology 118, pages 49-57.
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Alexander V. LyubimovRonald E. Savage. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 38 .
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Fredrik C. Kugelberg & Alan Wayne Jones. (2007) Interpreting results of ethanol analysis in postmortem specimens: A review of the literature. Forensic Science International 165:1, pages 10-29.
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Alan W Jones. (2006) Urine as a Biological Specimen for Forensic Analysis of Alcohol and Variability in the Urine-to-Blood Relationship. Toxicological Reviews 25:1, pages 15-35.
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John Caldwell. (2009) Drug metabolism and pharmacogenetics: the British contribution to fields of international significance. British Journal of Pharmacology 147:S1.
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J Bergstr?m, A Helander & A.W Jones. (2003) Ethyl glucuronide concentrations in two successive urinary voids from drinking drivers: relationship to creatinine content and blood and urine ethanol concentrations. Forensic Science International 133:1-2, pages 86-94.
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