History of Drug Metabolism: Discoveries of the Major Pathways in the 19th Century

References

• Lieben F. Geschichte der physiologischen Chemie. Deuticke, Leipzig 1935
   Google Scholar
• Florkin M. “A History of Biochemistry,”. Comprehensive Biochemistry, M. Florkin, E. H. Stotz. Elsevier, Amsterdam 1972; Vol. 30
   Google Scholar
• 1975; Vol. 31, Ref. 2
   Google Scholar
• Buchheim R. Lehrbuch der Arzneimittellehre. Voss, Leipzig 1859; 19
   Google Scholar
• Fränkel S. Die Arzneimittelsynthese auf Grundlage der Beziehungen zwischen chemischem Aufbau und Wirkung. Springer, Berlin 1901; 105–129, More detailed in 3rd ed., 1912, pp. 49–58, 159–206, 817–823.
   Google Scholar
• Heffter A. Ergeb. Physiol 1903; 2: 95
   Google Scholar
• Heffter A. Ergeb. Physiol 1905; 4: 184
   Google Scholar
• Williams R. T. Detoxication Mechanisms, 2nd ed. Chapman & Hall, London 1959; 13–22
   Google Scholar
• Smitli R. L., Williams R. T. “History of the Discovery of the Conjugation Mechanisms,”. Metabolic Conjugation and Metabolic Hydrolysis, W. H. Fishman. Academic, New York 1970; Vol. 1: 1
   Google Scholar
• Butler T. C. Ann. N. Y. Acad. Sci. 1971; 179: 502
   PubMed Web of Science ®Google Scholar
• Bickel M. H. Marceli Nencki 1847–1901. Huber, Bern 1972; 33–53
   Google Scholar
• Thompson T. A System of Chemistry. Edinburgh 1802; Vol. 4: 447
   Google Scholar
• Hallwachs W. Ann. Chem. Pharm 1858; 105: 207
   Google Scholar
• Berzelius J. Lehrbuch der Chemie, 3rd ed. Dresden 1840; Vol. 9: 425
   Google Scholar
• de Fourcroy A. F., Vauquelin L. N. Ann. Chim. Phys 1799; 31: 63
   Google Scholar
• Proust L. Ann. Chim. Phys 1801; 36: 273
   Google Scholar
• Wöbler F. Tiedemann's Z. Physiol 1824; 1: 142
   Google Scholar
• Liebig J. Poggendorff's Ann. Phys. Chem 1829; 17: 389
   Google Scholar
• Erdmann O. L. J. Prakt. Chem 1838; 13: 422
   Google Scholar
• Dumas J. A. Ann. Chim. Phys 1837; 57: 331
   Google Scholar
• Dessaignes V. C. R. Acad. Sci. (Paris) 1845; 21: 1224
   Google Scholar
• Dessaignes V. J. Pharm. (Paris) 1857; 32: 44
   Google Scholar
• Ure A. Pharm. J. Transact 1841; 1: 24
   Google Scholar
• Lehmann C. G. J. Prakt. Chem 1835; 6: 113
   Google Scholar
• Wöhler F. Lehrbuch der Chemie, J. Berzelius, Dresden 1831; Vol. 4: 376
   Google Scholar
• Keller W. Ann. Chem. Pharm 1842; 43: 108
   Google Scholar
• Liebig J. Ann. Chem. Pharm 1844; 50: 161
   Google Scholar
• Kühne W., Hallwachs W. Virchow's Arch. Pathol. Anat 1857; 12: 386
   Google Scholar
• Wöhler F., Frerichs F. T. Ann. Chem. Pharm 1848; 65: 335
   Google Scholar
• Strecker A. Ann. Chem. Pharm., 65 1848; 1: 130, 67, 1 (1848)
   Google Scholar
• Schwann T. du Bois-Reymond's Arch. Anat. Physiol 1844; 127
   Google Scholar
• Blondlot N. Mém. Soc. Sci. (Nancy) 1851
   Google Scholar
• Strecker A. Ann. Chem. Pharm 1849; 70: 149
   Google Scholar
• Hoppe-Seyler F. J. Prakt. Chem 1863; 89: 283
   Google Scholar
• Bunge G., Schmiedeberg O. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1876; 6: 233
   Google Scholar
• Meissner G., Shepard C. U. Untersuchungen liber das Entstehen der Hippursaure im tierischen Organismus. Hannover. 1866
   Google Scholar
• Ludwig C., Schmidt A. Arb. Physiol. Anstalt Leipzig 1868; 1
   Google Scholar
• Spengel L. “Ueber den chemischen Vorgang bei der Bildung der Hippursaiire im Tierkörper,”. Thesis, Bern 1875
   Google Scholar
• Hofftnann A. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1877; 7: 233
   Google Scholar
• Koch W. Pflüger's Arch. Physiol 1879; 20: 64
   Google Scholar
• Binz C. Arch. Mikrosk. Anat 1867; 2: 383
   Google Scholar
• Binz C. Virchow's Arch. Pathol. Anat 1869; 46: 129
   Google Scholar
• Scharrenbroich. “Das Chinin als Antiphlogisticum,”. Thesis, Bonn 1867
   Google Scholar
• Ure A., Liebig J. Ann. Chem. Pharm 1842; 44: 345
   Google Scholar
• Erdmann O. L., Marchand R. F. Ann. Chem. Pharm 1842; 44: 344
   Google Scholar
• Erdmann O. L., Marchand R. F. J. Prakt. Chem 1842; 26: 491
   Google Scholar
• Erdmann O. L., Marchand R. F. J. Prakt. Chem 1845; 35: 307
   Google Scholar
• Staedeler G. Ann. Chem. Pharm 1851; 77: 17
   Google Scholar
• Schlieper A. Ann. Chem. Pharm 1846; 59: 1
   Google Scholar
• Schultzen O., Naunyn B. du Bois-Reymond's Arch. Anat. Physiol 1867; 349
   Google Scholar
• Carius L. Ann. Chem. Pharm 1868; 148: 50
   Google Scholar
• Nencki M. du Bois-Reymond's Arch. Anat. Physiol 1870; 399
   Google Scholar
• Hofinann A. W. Ann. Chem. Pharm 1850; 74: 342
   Google Scholar
• Kraut C. Thesis, Göttingen 1854
   Google Scholar
• Kraut C. Ann. Chem. Pharm 1856; 98: 360
   Google Scholar
• Fittig R., König J. Ann. Chem. Pharm 1867; 144: 277
   Google Scholar
• Nencki M., Ziegler E. Ber. Dtsch. Chem. Ges. 1872; 5: 749
   Google Scholar
• Buchheim R. Arch. Physiol. Heakunde, [N.F.I] 1857; 1: 122
   Google Scholar
• Jacobsen O. Ber. Dtsch. Chem. Ges. 1879; 12: 1512
   Google Scholar
• Nencki M. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1873; 1: 420
   Google Scholar
• Schultzen O., Graebe C. du Bois-Reymond's Arch. Anat. Physiol 1867; 166
   Google Scholar
• Bertagnini C. Ann. Chem. Pharm 1851; 78: 100
   Google Scholar
• Jaffé M. Ber. Dtsch. Chem. Ges. 1873; 7: 248
   Google Scholar
• Bertagnini C. Ann. Chem. Pharm 1856; 97: 248
   Google Scholar
• Beilstein F., Schlun F. Ann. Chem. Pharm 1865; 133: 239
   Google Scholar
• Berg C. “De nonnullarum materiarum in urinam transitu disquisitiones,”. Thesis, Dorpat 1858
   Google Scholar
• Munk I. Pflüger's Arch. Physiol 1876; 12: 142
   Google Scholar
• Landolt H. Ber. Dtsch. Chem. Ges. 1871; 4: 770
   Google Scholar
• Nencki M., Sieber N. J. Prakt. Chem 1882; 26: 1
   Google Scholar
• Nencki M., Sieber N. J. Prakt. Chem 1881; 24: 498
   Google Scholar
• Nencki M., Sieber N. Pflüger's Arch. Physiol 1883; 31: 319
   Google Scholar
• Schultzen O., Riess L. Ann. Charité-Krankenh., (Berlin) 1869; 15: 57
   Google Scholar
• Quincke H. Virchow's Arch. Pathol. Anat 1872; 54: 537
   Google Scholar
• Schmidt A. Ueber Ozon im Blute. Dorpat 1862, Hämatologische Studien, Dorpat, 1865
   Google Scholar
• Schönbein C. F. Sitzungsber. K. Akad. Wiss. (Munich) 1863; 1: 274
   Google Scholar
• Clausius R. Poggendorff's Ann. Phys. Chem 1864; 121: 250
   Google Scholar
• Traube M. Theorie der Fermentwirkungen. Berlin 1858
   Google Scholar
• Binz C. Berl. Klin. Wochenschr 1872; 9: 638
   Google Scholar
• Pflüger E. Pflüger's Arch. Physiol 1872; 6: 43, 10, 251 (1875)
   Google Scholar
• Hoppe-Seyler F. Z. Physiol. Chem 1877; 1: 396
   Google Scholar
• Kaufmann C. J. Prakt. Chem 1878; 17: 79
   Google Scholar
• Nencki M., Giacosa P. Z. Physiol. Chem 1880; 4: 339
   Google Scholar
• Radziszewski B. Ann. Chem. Pharm 1880; 203: 305
   Google Scholar
• Buliginsky A. Hoppe-Seyler's Med.-Chem. Untersuchungen 1867; 2: 234
   Google Scholar
• Hoppe-Seyler F. Pflüger's Arch. Physiol 1872; 5: 470
   Google Scholar
• Staedeler G. Ann. Chem. Pharm 1867; 144: 295
   Google Scholar
• Baumann E. Pflüger's Arch. Physiol 1876; 12: 63
   Google Scholar
• Baumann E. Pflüger's Arch. Physiol 1876; 12: 69
   Google Scholar
• Baumann E. Ber. Dtsch. Chem. Ges. 1876; 9: 54
   Google Scholar
• Baumann E. Pflüger's Arch. Physiol 1876; 13: 285
   Google Scholar
• Baumann E. Ber. Dtsch. Chem. Ges. 1876; 9: 1389
   Google Scholar
• Baumann E., Herter E. Z. Physiol. Chem 1877; 1: 244
   Google Scholar
• Schuchardt B. Arch. Pharm 1861; 156: 144
   Google Scholar
• Sonnenkalb. Anilin und Anilinfarben. Leipzig 1864
   Google Scholar
• Schmiedeberg O. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1878; 8: 1
   Google Scholar
• Schmiedeberg O. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1881; 14: 288
   Google Scholar
• Schaffer F. J. Prakt. Chem 1878; 18: 282
   Google Scholar
• Tauber E. Z. Physiol. Chem 1878; 2: 366
   Google Scholar
• Auerbach A. Virchow's Arch. Pathol. Anat 1879; 77: 226
   Google Scholar
• Salkowski E. Virchow's Arch. Pathol. Anat 1878; 73: 409
   Google Scholar
• Salkowski E. Pflüger's Arch. Physiol 1872; 5: 335
   Google Scholar
• Baumann E., Preusse C. Z. Physiol. Chem 1879; 3: 156
   Google Scholar
• Nencki M., Giacosa P. Z. Physiol. Chem 1880; 4: 325
   Google Scholar
• Lautemann E. Ann. Chem. Pharm 1863; 125: 9
   Google Scholar
• Mattschersky P. Virchow's Arch. Pathol. Anat 1863; 28: 538
   Google Scholar
• Stadelmann E. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1879; 10: 317
   Google Scholar
• Förster W. Thesis, Breslau 1900
   Google Scholar
• Hupfer F. Z. Physiol. Chem 1903; 37: 302
   Google Scholar
• Schmidt J. Biochem. Zentralbl 1905; 3: 568
   Google Scholar
• Schulz O. “Untersuohungen über die Wirking des Chinons und einiger Chinonderivate,”. Thesis, Rostock 1892
   Google Scholar
• Conn S. “Ueber das Verhalten des Chinons im tierischen Organismus,”. Thesis, Königsberg 1893
   Google Scholar
• Hoppe-Seyler F. Z. Physiol. Chem 1882; 7: 178
   Google Scholar
• Rymsza A. “Ein Beitrag zur Toxikologie der Pikrinsaure,”. Thesis, Dorpat 1889
   Google Scholar
• Karplus J. P. Z. Klin. Med. 1893; 22: 210
   Google Scholar
• Sieber N., Smirnow A. Monatsh. Chem 1887; 8: 88
   Google Scholar
• Cohn R. Z. Physiol. Chem 1893; 17: 274
   Google Scholar
• Cohn R. Z. Physiol. Chem 1894; 18: 133
   Google Scholar
• Kobert R. Lehrbuch der Pharmakotherapie. Stuttgart 1897; 462
   Google Scholar
• Liebreich O. Das Chloralhydrat, ein neues Hypnoticum und Anastheticum. Berlin 1869
   Google Scholar
• Loebisch W. F. Die neueren Arzneimittel, 3rded. Vienna 1888
   Google Scholar
• Personne J. C. R. Acad. Sci. (Paris) 1869; 69: 979
   Google Scholar
• Hammarsten O. Upsala Läkarefören. Forehandl, 5: 424
   Google Scholar
• Rajewsky A. Centralbl. Med. Wissensch 1870; 8: 211
   Google Scholar
• Külz E. Sitzungsber. Ges. Beförd. Naturwiss. (Marburg) 1872; 2
   Google Scholar
• Bouchut M. C. R. Acad. Sci. (Paris) 1869; 69: 966
   Google Scholar
• Tomaszewicz A. Pflüger's Arch. Physiol 1874; 9: 35
   Google Scholar
• von Mering J., Musculus F. Ber. Dtsch. Chem. Ges. 1875; 8: 662
   Google Scholar
• Falck C. P. Dtsch. Z. Prakt. Med. 1877; 23: 64
   Google Scholar
• Külz E. Centralbl. Med. Wissensch 1881; 19: 337
   Google Scholar
• Schmiedeberg O., Meyer H. Z. Physiol. Chem 1879; 3: 422
   Google Scholar
• Külz E. Pflüger's Arch. Physiol 1882; 28: 506
   Google Scholar
• Garzarolli-Thurnlackh K. Ann. Chem. Pharm 1881; 210: 63
   Google Scholar
• von Mering J. Ber. Dtsch. Chem. Ges. 1882; 15: 1019
   Google Scholar
• von Mering J. Z. Physiol. Chem 1882; 6: 480
   Google Scholar
• Külz E. Z. Biol 1884; 20: 157
   Google Scholar
• Erdmann O. L. J. Prakt. Chem 1844; 33: 190, 37, 385 (1846)
   Google Scholar
• Schmid W. Ann. Chem. Pharm 1855; 93: 83
   Google Scholar
• Baeyer A. Ann. Chem. Pharm 1870; 155: 257
   Google Scholar
• Ewald C. A. Centralbl. Med. Wissensch 1873; U: 819, Jahresber. Thierchem., 3, 313 (1873)
   Google Scholar
• von Mering J. Centralbl. Med. Wissensch 1875; 13: 945, Jahresber. Thierchem., 5, 61 (1875)
   Google Scholar
• Jaffé M. Z. Physiol. Chem 1878; 2: 47
   Google Scholar
• Wiedemann C. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol 1877; 6: 216
   Google Scholar
• Jaffé M., Cohn R. Ber. Dtsch. Chem. Ges. 1887; 20: 2311
   Google Scholar
• Baeyer A. Ber. Dtsch. Chem. Ges. 1877; 10: 355
   Google Scholar