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Hemoglobin
international journal for hemoglobin research
Volume 39, 2015 - Issue 1
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Review Article

Cardiomyopathy Associated with Iron Overload: How Does Iron Enter Myocytes and What are the Implications for Pharmacological Therapy?

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Pages 9-17 | Received 30 Apr 2014, Accepted 14 Jul 2014, Published online: 09 Jan 2015

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Read on this site (3)

Arwa Khaled, Hoda A Salem, Dina A Ezzat, Hadeel M Seif & Hoda Rabee. (2019) A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major. Drug Design, Development and Therapy 13, pages 2427-2436.
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Amal Paul, Viji S Thomson, Marwan Refaat, Bader Al-Rawahi, Ali Taher & Sunil K Nadar. (2019) Cardiac involvement in beta-thalassaemia: current treatment strategies. Postgraduate Medicine 131:4, pages 261-267.
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Natthaphat Siri-Angkul, Siriporn C Chattipakorn & Nipon Chattipakorn. (2018) Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients. Expert Review of Hematology 11:6, pages 471-479.
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Kyoko Komai, Nicholas K. Kawasaki, Jason K. Higa & Takashi Matsui. (2022) The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction. Cells 11:9, pages 1399.
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Sanaz Asadian, Leila Hosseini & Nahid Rezaeian. (2022) The Importance of Functional and Feature-Tracking Cardiac MRI Parameters in Prediction of Adverse Cardiac Events and Cardiac Mortality in Thalassemia Patients. Academic Radiology 29, pages S91-S99.
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Nahid Rezaeian, Sanaz Asadian, Mozhgan Parsaee, Yaser Toloueitabar, Mohammad Mehdi Hemmati Komasi, Leila Shayan & Leila Hosseini. (2021) The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension. Echocardiography 38:10, pages 1769-1777.
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Hossein Karami, Hadiseh Khalilzadeh Arjmandi, Ebrahim Salehifar, Hadi Darvishi‐Khezri, Mojdeh Dabirian, Mehrnoush Kosaryan, Aily Aliasgharian, Rosetta Akbarzadeh, Raheleh Naeimayi Aali & Amirreza Nasirzadeh. (2021) A double‐blind, controlled, crossover trial of amlodipine on iron overload status in transfusion dependent β‐thalassemia patients. International Journal of Clinical Practice 75:8.
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Yuanyuan Zhang, Yucong Xue, Bin Zheng, Xue Han, Donglai Ma, Zhihong Ma, Shengjiang Guan, Yonggang Gao, Ziliang Li & Li Chu. (2021) Salvia miltiorrhiza (SM) Injection Ameliorates Iron Overload-Associated Cardiac Dysfunction by Regulating the Expression of DMT1, TfR1, and FP1 in Rats. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-9.
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Yan Chen, Jing Wan, Haidan Xia, Ya Li, Yufeng Xu, Haiyan Lin & Hassah Iftikhar. (2020) Total iron binding capacity (TIBC) is a potential biomarker of left ventricular remodelling for patients with iron deficiency anaemia. BMC Cardiovascular Disorders 20:1.
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Dimitrios Patsourakos, Konstantinos A. Gatzoulis, Constantina Aggeli, Sophia Delicou, Yannis Dimitroglou, Katerina Xydaki, Konstantinos Toutouzas, Aristeidis Androulakis & Dimitrios Tousoulis. (2020) Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients. Journal of Arrhythmia 36:5, pages 920-928.
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Driton Vela. (2019) Keeping heart homeostasis in check through the balance of iron metabolism. Acta Physiologica 228:1.
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Na Liu, Liangqiang Zou, Mei Hu & Man Zhang. (2019) Heme as a target for protection against doxorubicin-induced apoptosis in H9c2 cardiomyocytes. Cell Stress and Chaperones 24:6, pages 1211-1217.
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Majid Ghanavat, Habib Haybar, Seyed Mohammad Sadegh Pezeshki, Mohammad Shahjahani, Hosein Jodat, Milad Elyasi & Najmaldin Saki. (2019) Cardiomyopathy in Thalassemia: Quick Review from Cellular Aspects to Diagnosis and Current Treatments. Laboratory Medicine.
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F. Koohi, T. Kazemi & E. Miri-Moghaddam. (2019) Cardiac complications and iron overload in beta thalassemia major patients—a systematic review and meta-analysis. Annals of Hematology 98:6, pages 1323-1331.
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Natthaphat Siri‐Angkul, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2018) Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy. Journal of Cellular Physiology 233:7, pages 5104-5111.
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Carles Díez-López, Josep Comín-Colet & José González-Costello. (2018) Iron overload cardiomyopathy. Current Opinion in Cardiology 33:3, pages 334-340.
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Mei-Jou Chen, Steven Shinn-Forng Peng, Meng-Yao Lu, Yung-Li Yang, Shiann-Tarng Jou, Hsiu-Hao Chang, Shee-Uan Chen, Dong-Tsamn Lin & Kai-Hsin Lin. (2017) Effect of iron overload on impaired fertility in male patients with transfusion-dependent beta-thalassemia. Pediatric Research 83:3, pages 655-661.
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Paraskevi Rea Oikonomidou & Stefano Rivella. (2018) What can we learn from ineffective erythropoiesis in thalassemia?. Blood Reviews 32:2, pages 130-143.
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John C. Wood. (2017) The use of MRI to monitor iron overload in SCD. Blood Cells, Molecules, and Diseases 67, pages 120-125.
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Zeynep Ozturk, Gizem Esra Genc & Saadet Gumuslu. (2017) Minerals in thalassaemia major patients: An overview. Journal of Trace Elements in Medicine and Biology 41, pages 1-9.
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Rawan Eid, Nagla T.T. Arab & Michael T. Greenwood. (2017) Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:2, pages 399-430.
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G. E. Genc, Z. Ozturk & S. Gumuslu. (2017) Selenoproteins are involved in antioxidant defense systems in thalassemia. Metallomics 9:9, pages 1241-1250.
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Yumiko Kanzaki, Masako Yuki, Ken-ichiro Yamamura, Yoshifumi Narumi & Nobukazu Ishizaka. (2016) Is cardiac and hepatic iron status assessed by MRI T2* associated with left ventricular function in patients with idiopathic cardiomyopathy?. Heart and Vessels 31:12, pages 1950-1959.
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Paraskevi Rea Oikonomidou, Carla Casu & Stefano Rivella. (2016) New strategies to target iron metabolism for the treatment of beta thalassemia. Annals of the New York Academy of Sciences 1368:1, pages 162-168.
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Suwakon Wongjaikam, Sirinart Kumfu, Siriporn C. Chattipakorn, Suthat Fucharoen & Nipon Chattipakorn. (2015) Current and future treatment strategies for iron overload cardiomyopathy. European Journal of Pharmacology 765, pages 86-93.
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