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Original Article

Low powder mass filling of dry powder inhalation formulations

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Pages 24-32 | Received 04 Jan 2010, Accepted 26 Apr 2010, Published online: 12 Aug 2010

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S. Stranzinger, E. Faulhammer, S. Biserni, A. Ferrari, G. D'Elpidio, S. Cicognani & J. G. Khinast. (2023) Micro-dosing of powders into capsules using a new automated micro-dosing system: effect of powder characteristics and operating conditions on the filling of 0.5 mg–100 mg weights. Drug Development and Industrial Pharmacy 49:7, pages 448-455.
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Anne Haaije de Boer, Paul Hagedoorn & Floris Grasmeijer. (2022) Dry powder inhalation, part 2: the present and future. Expert Opinion on Drug Delivery 19:9, pages 1045-1059.
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Gizem Rüya Topal, Burcu Devrim, Müjde Eryilmaz & Asuman Bozkir. (2018) Design of ciprofloxacin-loaded nano-and microcomposite particles for dry powder inhaler formulations: preparation, in vitro characterisation, and antimicrobial efficacy. Journal of Microencapsulation 35:6, pages 533-547.
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E. Faulhammer, M. Llusa, P. R. Wahl, A. Paudel, S. Lawrence, S. Biserni, V. Calzolari & J. G. Khinast. (2016) Development of a design space and predictive statistical model for capsule filling of low-fill-weight inhalation products. Drug Development and Industrial Pharmacy 42:2, pages 221-230.
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Articles from other publishers (11)

Hao Lou, Li Ding, Tian Wu, Weikun Li, Ryan Khalaf, Hugh D. C. Smyth & Darren L. Reid. (2023) Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations. Molecular Pharmaceutics 20:11, pages 5332-5344.
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Varsha V. Nair & Hugh D. C. Smyth. (2023) Inhalable Excipient-Free Dry Powder of Tigecycline for the Treatment of Pulmonary Infections. Molecular Pharmaceutics 20:9, pages 4640-4653.
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Gerald A. Hebbink, Maarten Jaspers, Harry J.W. Peters & Bastiaan H.J. Dickhoff. (2022) Recent developments in lactose blend formulations for carrier-based dry powder inhalation. Advanced Drug Delivery Reviews 189, pages 114527.
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Lucilla C. Almeida, Rahul Bharadwaj, Avi Eliahu, Carl R. Wassgren, Karthik Nagapudi & Ariel R. Muliadi. (2022) Capsule-Based dry powder inhaler evaluation using CFD-DEM simulations and next generation impactor data. European Journal of Pharmaceutical Sciences 175, pages 106226.
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Anne Haaije de Boer & Kyrre Thalberg. 2021. Inhaled Medicines. Inhaled Medicines 99 146 .
Fridrun Podczeck. 2017. Pharmaceutical Dosage Forms. Pharmaceutical Dosage Forms 237 282 .
Stephan Sacher & Johannes G. Khinast. 2016. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture 311 383 .
M.O. Besenhard, E. Faulhammer, S. Fathollahi, G. Reif, V. Calzolari, S. Biserni, A. Ferrari, S.M. Lawrence, M. Llusa & J.G. Khinast. (2015) Accuracy of micro powder dosing via a vibratory sieve–chute system. European Journal of Pharmaceutics and Biopharmaceutics 94, pages 264-272.
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Eva Faulhammer, Marlies Fink, Marcos Llusa, Simon M. Lawrence, Stefano Biserni, Vittorio Calzolari & Johannes G. Khinast. (2014) Low-dose capsule filling of inhalation products: Critical material attributes and process parameters. International Journal of Pharmaceutics 473:1-2, pages 617-626.
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Eike Cordts & Hartwig Steckel. (2014) Formulation considerations for dry powder inhalers. Therapeutic Delivery 5:6, pages 675-689.
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S. Stegemann, S. Kopp, G. Borchard, V.P. Shah, S. Senel, R. Dubey, N. Urbanetz, M. Cittero, A. Schoubben, C. Hippchen, D. Cade, A. Fuglsang, J. Morais, L. Borgström, F. Farshi, K.-H. Seyfang, R. Hermann, A. van de Putte, I. Klebovich & A. Hincal. (2013) Developing and advancing dry powder inhalation towards enhanced therapeutics. European Journal of Pharmaceutical Sciences 48:1-2, pages 181-194.
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