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Research Article

Selection of excipient, solvent and packaging to optimize the performance of spray-dried formulations: case example fenofibrate

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Pages 402-412 | Received 05 Nov 2011, Accepted 10 Apr 2012, Published online: 17 May 2012

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Read on this site (3)

Abid Mehmood Yousaf, Muhammad Ramzan, Yasser Shahzad, Tariq Mahmood & Muhammad Jamshaid. (2019) Fabrication and in vitro characterization of fenofibric acid-loaded hyaluronic acid–polyethylene glycol polymeric composites with enhanced drug solubility and dissolution rate. International Journal of Polymeric Materials and Polymeric Biomaterials 68:9, pages 510-515.
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Abid Mehmood Yousaf, Dong Wuk Kim, Dong Shik Kim, Jong Oh Kim, Yu Seok Youn, Kwan Hyung Cho, Chul Soon Yong & Han-Gon Choi. (2016) Influence of polyvinylpyrrolidone quantity on the solubility, crystallinity and oral bioavailability of fenofibrate in solvent-evaporated microspheres. Journal of Microencapsulation 33:4, pages 365-371.
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T. L. Durli, F. A. Dimer, M. C. Fontana, A. R. Pohlmann, R. C. R. Beck & S. S. Guterres. (2014) Innovative approach to produce submicron drug particles by vibrational atomization spray drying: influence of the type of solvent and surfactant. Drug Development and Industrial Pharmacy 40:8, pages 1011-1020.
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Articles from other publishers (21)

Mobina Manzoor, Syed Atif Raza, Mulazim Hussain Asim, Nadeem Irfan Bukhari, Shumaila Arshad & Uzma Zafar. (2022) Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and Dissolution Enhancer in Solid Dispersion. Pharmaceuticals 15:7, pages 869.
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Sien Dedroog, Peter Adriaensens & Guy Van den Mooter. (2022) Gaining Insight into the Role of the Solvent during Spray Drying of Amorphous Solid Dispersions by Studying Evaporation Kinetics. Molecular Pharmaceutics 19:5, pages 1604-1618.
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Molly Adam, Warren Miller, Amanda Pluntze, Aaron Stewart, Jonathan Cape, Michael Grass & Michael Morgen. (2022) Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture. Pharmaceutics 14:3, pages 555.
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Heather R. Campbell, Fahd M. Alsharif, Patrick J. Marsac & Robert A. Lodder. (2020) The Development of a Novel Pharmaceutical Formulation of D-Tagatose for Spray-Drying. Journal of Pharmaceutical Innovation 17:1, pages 194-206.
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Hongwei Zhang, Minglu Li, Jianmin Li, Anjali Agrawal, Ho-Wah Hui & Demin Liu. (2022) Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions. Pharmaceutics 14:2, pages 428.
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Susanne Page, Reto Maurer, Nicole Wyttenbach & Felix Ditzinger. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 287 326 .
Sien Dedroog, Eline Boel, Célestine Kindts, Bernard Appeltans & Guy Van den Mooter. (2021) The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions. International Journal of Pharmaceutics 609, pages 121201.
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Yayoi Kawano, Shiyang Chen & Takehisa Hanawa. (2021) Solubility Enhancement of Ibuprofen by Adsorption onto Spherical Porous Calcium Silicate. Pharmaceutics 13:6, pages 767.
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Xiaoting Zhang, Qiuhong Rao, Zhenwen Qiu, Yisheng Lin, Lei Zhang, Qingzhong Hu, Tingting Chen, Zhimin Ma, Hanlu Gao, Dandong Luo, Jiaqi Zhao, Defang Ouyang, Zhenyu Jason Zhang & Qingguo Li. (2021) Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions. Journal of Pharmaceutical Sciences 110:3, pages 1160-1171.
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Matthew K. Defrese, Matthew A. Farmer, Yuhan Long, Lucas R. Timmerman, Younsoo Bae & Patrick J. Marsac. (2020) Approaches to Understanding the Solution-State Organization of Spray-Dried Dispersion Feed Solutions and Its Translation to the Solid State. Molecular Pharmaceutics 17:12, pages 4548-4563.
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Eylul Cetindag, John Pentangelo, Thierry Arrieta Cespedes & Rajesh N. Davé. (2020) Effect of solvents and cellulosic polymers on quality attributes of films loaded with a poorly water-soluble drug. Carbohydrate Polymers 250, pages 117012.
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Saman Ali, Abid Mehmood Yousaf, Syed Atif Raza, Yasser Shahzad, Ikram Ullah Khan, Tariq Mahmood, Talib Hussain, Mobina Manzoor, Humayun Riaz & Muhammad Jamshaid. (2019) Preparation and in vitro characterization of polyvinylpyrrolidone-poloxamer polymeric synergy for oral drug delivery. Journal of Polymer Research 26:7.
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Sadegh Poozesh, Nico Setiawan, Nelson K. Akafuah, Kozo Saito & Patrick J. Marsac. (2018) Assessment of predictive models for characterizing the atomization process in a spray dryer’s bi-fluid nozzle. Chemical Engineering Science 180, pages 42-51.
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Mark Davis & Gavin Walker. (2018) Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs. Journal of Controlled Release 269, pages 110-127.
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Luz Mary Santiago, Alex Tarancón, Héctor Bagán & José Francisco García. (2015) Production of polystyrene-based scintillation microspheres for the measurement of radioactivity by spray-drying. Journal of Radioanalytical and Nuclear Chemistry 308:3, pages 789-799.
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Susanne Page, Reto Maurer & Nicole Wyttenbach. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 329 382 .
P. Kanaujia, P. Poovizhi, W.K. Ng & R.B.H. Tan. (2015) Amorphous formulations for dissolution and bioavailability enhancement of poorly soluble APIs. Powder Technology 285, pages 2-15.
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Joseph P. O?Shea, Waleed Faisal, Therese Ruane-O?Hora, Ken J. Devine, Edmund S. Kostewicz, Caitriona M. O?Driscoll & Brendan T. Griffin. (2015) Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments. European Journal of Pharmaceutics and Biopharmaceutics 96, pages 207-216.
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Yan He & Chris Ho. (2015) Amorphous Solid Dispersions: Utilization and Challenges in Drug Discovery and Development. Journal of Pharmaceutical Sciences 104:10, pages 3237-3258.
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Bhavesh B. Patel, Jayvadan K. Patel, Subhashis Chakraborty & Dali Shukla. (2015) Revealing facts behind spray dried solid dispersion technology used for solubility enhancement. Saudi Pharmaceutical Journal 23:4, pages 352-365.
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Adele Patterson, Ana P. Ferreira, Elizabeth Banks, Kirsty Skeene, Graham Clarke, Sarah Nicholson & Clare Rawlinson-Malone. (2015) Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation. International Journal of Pharmaceutics 478:1, pages 348-360.
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