Selection of excipient, solvent and packaging to optimize the performance of spray-dried formulations: case example fenofibrate

References

• Benet LZ, Wu C, Custodio JM. Predicting drug absorption and the effects of food on oral bioavailability. Bulletin Technique Gattefosse 2006;99:9–16.
   Google Scholar
• Prentis RA, Lis Y, Walker SR. (1988). Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br J Clin Pharmacol, 25:387–396.
   PubMed Web of Science ®Google Scholar
• Lipinski CA. Poor Aqueous Solubility – an Industry Wide Problem in Drug Discovery. Am Pharm Rev 2002;5:82–85.
   Google Scholar
• Hancock BC, Zografi G. (1997). Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci, 86:1–12.
   PubMed Web of Science ®Google Scholar
• Helliwell M, Taylor D. (1993). Solid oral dosage forms. Prof Nurse, 8:313–317.
   PubMedGoogle Scholar
• Corrigan DO, Healy AM, Corrigan OI. (2003). The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials. Int J Pharm, 262:125–137.
   PubMed Web of Science ®Google Scholar
• Janssens S, de Armas HN, Roberts CJ, Van den Mooter G. (2008). Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5. J Pharm Sci, 97:2110–2120.
   PubMed Web of Science ®Google Scholar
• Patterson JE, James MB, Forster AH, Lancaster RW, Butler JM, Rades T. (2007). Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling. Int J Pharm, 336:22–34.
   PubMed Web of Science ®Google Scholar
• Van den Mooter G, Weuts I, De Ridder T, Blaton N. (2006). Evaluation of Inutec SP1 as a new carrier in the formulation of solid dispersions for poorly soluble drugs. Int J Pharm, 316:1–6.
   PubMed Web of Science ®Google Scholar
• Maas J, Kamm W, Hauck G. (2007). An integrated early formulation strategy–from hit evaluation to preclinical candidate profiling. Eur J Pharm Biopharm, 66:1–10.
   PubMed Web of Science ®Google Scholar
• Granero GE, Ramachandran C, Amidon GL. (2005). Dissolution and solubility behavior of fenofibrate in sodium lauryl sulfate solutions. Drug Dev Ind Pharm, 31:917–922.
   PubMed Web of Science ®Google Scholar
• Amidon GL, Lennernäs H, Shah VP, Crison JR. (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res, 12:413–420.
   PubMed Web of Science ®Google Scholar
• Najib J. (2002). Fenofibrate in the treatment of dyslipidemia: a review of the data as they relate to the new suprabioavailable tablet formulation. Clin Ther, 24:2022–2050.
   PubMed Web of Science ®Google Scholar
• Pan X, Julian T, Augsburger L. Quantitative Measurement of Indomethacin Crystallinity in Indomethacin-Silica Gel Binary System Using Differential Scanning Calorimetry and X-ray Powder Diffractometry. AAPS Pharm Sci Tech 2007;7: Article 11.
   Web of Science ®Google Scholar
• Pan X, Julian T, Augsburger L. (2008). Increasing the dissolution rate of a low-solubility drug through a crystalline-amorphous transition: a case study with indomethacin [correction of indomethicin]. Drug Dev Ind Pharm, 34:221–231.
   PubMed Web of Science ®Google Scholar
• Jones RM. Particle size analysis by laser diffraction: ISO 13320, standard operating procedures, and Mie theory. American Laboratory 2003:44–47.
   Web of Science ®Google Scholar
• Shekunov BY, Chattopadhyay P, Tong HH, Chow AH. (2007). Particle size analysis in pharmaceutics: principles, methods and applications. Pharm Res, 24:203–227.
   PubMed Web of Science ®Google Scholar
• Dressman JB, Amidon GL, Reppas C, Shah VP. (1998). Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms. Pharm Res, 15:11–22.
   PubMed Web of Science ®Google Scholar
• Zoeller T, Klein S. Simplified Biorelevant Media for Screening Dissolution Performance of Poorly Soluble Drugs. Dissolution Technologies 2007;14:8–13.
   Web of Science ®Google Scholar
• Council of Europe. Fenofibrate. In: Council of Europe, ed. European Pharmacopoeia 5th Edition. Strasbourg: Directorate for the Quality of Medicines of the Council of Europe, 2004:1581–1583.
   Google Scholar
• ICH Expert Working Group. Stability Testing of New Drug Substances and Products Q1A(R2). ICH [Online] 2003. Available at: http://www.ich.org/products/guidelines/quality/article/quality-guidelines.html. Accessed on 16 July 2011.
   Google Scholar
• Shmeis RA, Wang Z, Krill SL. (2004). A mechanistic investigation of an amorphous pharmaceutical and its solid dispersions, part I: a comparative analysis by thermally stimulated depolarization current and differential scanning calorimetry. Pharm Res, 21:2025–2030.
   PubMed Web of Science ®Google Scholar
• Forster A, Hempenstall J, Tucker I, Rades T. (2001). Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis. Int J Pharm, 226:147–161.
   PubMed Web of Science ®Google Scholar
• Chokshi RJ, Sandhu HK, Iyer RM, Shah NH, Malick AW, Zia H. (2005). Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion processs as a means to manufacture solid dispersion/solution. J Pharm Sci, 94:2463–2474.
   PubMed Web of Science ®Google Scholar
• Langer M, Höltje M, Urbanetz NA, Brandt B, Höltje HD, Lippold BC. (2003). Investigations on the predictability of the formation of glassy solid solutions of drugs in sugar alcohols. Int J Pharm, 252:167–179.
   PubMed Web of Science ®Google Scholar
• Marsac PJ, Shamblin SL, Taylor LS. (2006). Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm Res, 23:2417–2426.
   PubMed Web of Science ®Google Scholar
• Vasanthavada M, Tong WQ, Joshi Y, Kislalioglu MS. (2004). Phase behavior of amorphous molecular dispersions I: Determination of the degree and mechanism of solid solubility. Pharm Res, 21:1598–1606.
   PubMed Web of Science ®Google Scholar
• Van den Mooter G, Wuyts M, Blaton N, Busson R, Grobet P, Augustijns P et al. (2001). Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25. Eur J Pharm Sci, 12:261–269.
   PubMed Web of Science ®Google Scholar
• Six K, Verreck G, Peeters J, Brewster M, Van Den Mooter G. (2004). Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast- and slow-dissolving polymers. J Pharm Sci, 93:124–131.
   PubMed Web of Science ®Google Scholar
• Couchman PR, Karasz FE. A Classical Thermodynamic Discussion of the Effect of Composition on Glass-Transition Temperatures. Macromolecules 1978;11:117–119.
   Web of Science ®Google Scholar
• Couchman PR. Compositional Variation of Glass-Transition Temperatures. 2. Application of the Thermodynamic Theory to Compatible Polymer Blends. Macromolecules 1978;11:1156–1161.
   Web of Science ®Google Scholar
• Schneider HA. Conformational Entropy Contributions to the Glass Temperature of Blends of Miscible Polymers. J Res Natl Inst Stand Technol 1997;102:229–248.
   Web of Science ®Google Scholar
• Kwei TK. The Effect of Hydrogen Bonding on the Glass Transition Temperatures of Polymer Mixtures. Journal of Polymer Science: Polymer Letters Edition 1984;22:307–313.
   Web of Science ®Google Scholar
• Kwei TK, Pearce EM, Pennacchia JR, Charton M. Correlation between the Glass Transition Temperatures of Polymer Mixtures and Intermolecular Force Parameters. Macromolecules 1987;20:1174–1176.
   Web of Science ®Google Scholar
• Tajber L, Corrigan OI, Healy AM. (2005). Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites–analysis of glass transition composition relationships. Eur J Pharm Sci, 24:553–563.
   PubMed Web of Science ®Google Scholar
• ICH Expert Working Group. Impurities: Guideline for Residual Solvents Q3C(R5). ICH [Online] 2011 Available at: http://www.ich.org/products/guidelines/quality/article/quality-guidelines.html. Accessed on 16 July 2011.
   Google Scholar
• Hino T, Shimabayashi S, Ohnishi N, Fujisaki M, Mori H, Watanabe O et al. (2000). Development of a new type nozzle and spray-drier for industrial production of fine powders. Eur J Pharm Biopharm, 49:79–85.
   PubMed Web of Science ®Google Scholar
• Ozeki T, Beppu S, Mizoe T, Takashima Y, Yuasa H, Okada H. (2005). Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier. J Control Release, 107:387–394.
   PubMed Web of Science ®Google Scholar
• Chen R, Okamoto H, Danjo K. (2008). Preparation of functional composite particles of salbutamol sulfate using a 4-fluid nozzle spray-drying technique. Chem Pharm Bull, 56:254–259.
   PubMed Web of Science ®Google Scholar
• Asada M, Takahashi H, Okamoto H, Tanino H, Danjo K. (2004). Theophylline particle design using chitosan by the spray drying. Int J Pharm, 270:167–174.
   PubMed Web of Science ®Google Scholar
• Corrigan DO, Corrigan OI, Healy AM. (2004). Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems. Int J Pharm, 273:171–182.
   PubMed Web of Science ®Google Scholar
• Takeuchi H, Nagira S, Yamamoto H, Kawashima Y. (2005). Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method. Int J Pharm, 293:155–164.
   PubMed Web of Science ®Google Scholar
• Columbano A, Buckton G, Wikeley P. (2003). Characterisation of surface modified salbutamol sulphate-alkylpolyglycoside microparticles prepared by spray drying. Int J Pharm, 253:61–70.
   PubMed Web of Science ®Google Scholar
• Vehring R, Foss WR, Lechuga-Ballesteros D. Particle formation in spray-drying. Aerosol Science 2007;38:728–746.
   Web of Science ®Google Scholar
• Vehring R. (2008). Pharmaceutical particle engineering via spray drying. Pharm Res, 25:999–1022.
   PubMed Web of Science ®Google Scholar
• Vogt M, Kunath K, Dressman JB. (2008). Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations. Eur J Pharm Biopharm, 68:283–288.
   PubMed Web of Science ®Google Scholar
• Jijun F, Lishuang X, Xiaoli W, Shu Z, Xiaoguang T, Xingna Z et al. (2011). Nimodipine (NM) tablets with high dissolution containing NM solid dispersions prepared by hot-melt extrusion. Drug Dev Ind Pharm, 37:934–944.
   PubMed Web of Science ®Google Scholar
• Maestrelli F, Zerrouk N, Cirri M, Mennini N, Mura P. (2008). Microspheres for colonic delivery of ketoprofen-hydroxypropyl-beta-cyclodextrin complex. Eur J Pharm Sci, 34:1–11.
   PubMed Web of Science ®Google Scholar
• Brewster ME, Vandecruys R, Peeters J, Neeskens P, Verreck G, Loftsson T. (2008). Comparative interaction of 2-hydroxypropyl-beta-cyclodextrin and sulfobutylether-beta-cyclodextrin with itraconazole: phase-solubility behavior and stabilization of supersaturated drug solutions. Eur J Pharm Sci, 34:94–103.
   PubMed Web of Science ®Google Scholar
• Council of Europe. Poly(vinyl acetate).. In: Council of Europe, ed. European Pharmacopoeia, 5th Edition Strasbourg: Directorate for the Quality of Medicines of the Council of Europe, 2004:2271–2272.
   Google Scholar
• Vogt M, Kunath K, Dressman JB. (2008). Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients. Eur J Pharm Biopharm, 68:330–337.
   PubMed Web of Science ®Google Scholar
• Tanno F, Nishiyama Y, Kokubo H, Obara S. (2004). Evaluation of hypromellose acetate succinate (HPMCAS) as a carrier in solid dispersions. Drug Dev Ind Pharm, 30:9–17.
   PubMed Web of Science ®Google Scholar
• Al-Obaidi H, Brocchini S, Buckton G. (2009). Anomalous properties of spray dried solid dispersions. J Pharm Sci, 98:4724–4737.
   PubMed Web of Science ®Google Scholar
• Bain DF, Munday DL, Smith A. (1999). Solvent influence on spray-dried biodegradable microspheres. J Microencapsul, 16:453–474.
   PubMed Web of Science ®Google Scholar
• Dontireddy R, Crean AM. (2011). A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions. Drug Dev Ind Pharm, 37:1141–1149.
   PubMed Web of Science ®Google Scholar
• Loftsson T, Brewster ME. (1996). Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci, 85:1017–1025.
   PubMed Web of Science ®Google Scholar
• Hancock BC, Zografi G. (1994). The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharm Res, 11:471–477.
   PubMed Web of Science ®Google Scholar
• Kauzmann W. The Nature of the Glassy State and the Behavior of Liquids at low Temperatures. Chem Rev 1948;43:219–256.
   Web of Science ®Google Scholar
• Hancock BC, Christensen K, Shamblin SL. (1998). Estimating the critical molecular mobility temperature (T(K)) of amorphous pharmaceuticals. Pharm Res, 15:1649–1651.
   PubMed Web of Science ®Google Scholar
• Leuner C, Dressman J. (2000). Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm, 50:47–60.
   PubMed Web of Science ®Google Scholar
• Brewster ME, Loftsson T. (2007). Cyclodextrins as pharmaceutical solubilizers. Adv Drug Deliv Rev, 59:645–666.
   PubMed Web of Science ®Google Scholar
• Rasenack N, Müller BW. Poorly Water-soluble Drugs for Oral Delivery - A Challenge for Pharmaceutical Development – Part II: Micronization technologies and complex formation. Pharm. Ind. 2005;67:447–451.
   Web of Science ®Google Scholar
• Stegemann S, Leveiller F, Franchi D, de Jong H, Lindén H. (2007). When poor solubility becomes an issue: from early stage to proof of concept. Eur J Pharm Sci, 31:249–261.
   PubMed Web of Science ®Google Scholar
• Pinnamaneni S, Das NG, Das SK. (2002). Formulation approaches for orally administered poorly soluble drugs. Pharmazie, 57:291–300.
   PubMed Web of Science ®Google Scholar
• Blagden N, de Matas M, Gavan PT, York P. (2007). Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev, 59:617–630.
   PubMed Web of Science ®Google Scholar
• Chaumeil JC. (1998). Micronization: a method of improving the bioavailability of poorly soluble drugs. Methods Find Exp Clin Pharmacol, 20:211–215.
   PubMed Web of Science ®Google Scholar
• Rasenack N, Müller BW. Poorly Water-soluble Drugs for Oral Delivery - A Challenge for Pharmaceutical Development - Part I: Physicochemical and biopharmaceutical background/Strategies in pharmaceutical development. Pharm. Ind. 2005;67:323–326.
   Web of Science ®Google Scholar
• Kesisoglou F, Panmai S, Wu Y. (2007). Nanosizing–oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev, 59:631–644.
   PubMed Web of Science ®Google Scholar
• Stella VJ, Nti-Addae KW. (2007). Prodrug strategies to overcome poor water solubility. Adv Drug Deliv Rev, 59:677–694.
   PubMed Web of Science ®Google Scholar
• Tang B, Cheng G, Gu JC, Xu CH. (2008). Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today, 13:606–612.
   PubMed Web of Science ®Google Scholar
• Rasenack N, Müller BW. Poorly Water-soluble Drugs for Oral Delivery - A Challenge for Pharmaceutical Development - Part III: Drug delivery systems containing the drug molecularly dispersed/Aspects on in vitro and in vivo characterization. Pharm. Ind. 2005;67:583–591.
   Web of Science ®Google Scholar
• Sethia S, Squillante E. (2003). Solid dispersions: revival with greater possibilities and applications in oral drug delivery. Crit Rev Ther Drug Carrier Syst, 20:215–247.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Chen R, Okamoto H, Danjo K. (2005). Acetaminophen particle design using chitosan and a spray-drying technique. Chem Pharm Bull, 53:37–41.
   PubMed Web of Science ®Google Scholar
• Figueiras A, Carvalho RA, Ribeiro L, Torres-Labandeira JJ, Veiga FJ. (2007). Solid-state characterization and dissolution profiles of the inclusion complexes of omeprazole with native and chemically modified beta-cyclodextrin. Eur J Pharm Biopharm, 67:531–539.
   PubMed Web of Science ®Google Scholar
• Jug M, Becirevic-Lacan M. (2004). Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose. Drug Dev Ind Pharm, 30:1051–1060.
   PubMed Web of Science ®Google Scholar
• Koester LS, Mayorga P, Bassani VL. (2003). Carbamazepine/betaCD/HPMC solid dispersions. I. Influence of the spray-drying process and betaCD/HPMC on the drug dissolution profile. Drug Dev Ind Pharm, 29:139–144.
   PubMed Web of Science ®Google Scholar
• Koester LS, Mayorga P, Pereira VP, Petzhold CL, Bassani VL. (2003). Carbamazepine/betaCD/HPMC solid dispersions. II. Physical characterization. Drug Dev Ind Pharm, 29:145–154.
   PubMed Web of Science ®Google Scholar
• Jung JY, Yoo SD, Lee SH, Kim KH, Yoon DS, Lee KH. (1999). Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique. Int J Pharm, 187:209–218.
   PubMed Web of Science ®Google Scholar
• Al-Zoubi N, Alkhatib HS, Bustanji Y, Aiedeh K, Malamataris S. (2008). Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions. Eur J Pharm Biopharm, 69:735–742.
   PubMed Web of Science ®Google Scholar
• Otsuka M, Onoe M, Matsuda Y. (1993). Hygroscopic stability and dissolution properties of spray-dried solid dispersions of furosemide with Eudragit. J Pharm Sci, 82:32–38.
   PubMed Web of Science ®Google Scholar
• Shimpi SL, Chauhan B, Mahadik KR, Paradkar A. (2005). Stabilization and improved in vivo performance of amorphous etoricoxib using Gelucire 50/13. Pharm Res, 22:1727–1734.
   PubMed Web of Science ®Google Scholar
• Chauhan B, Shimpi S, Paradkar A. (2005). Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique. Eur J Pharm Sci, 26:219–230.
   PubMed Web of Science ®Google Scholar
• Ambike AA, Mahadik KR, Paradkar A. (2004). Stability study of amorphous valdecoxib. Int J Pharm, 282:151–162.
   PubMed Web of Science ®Google Scholar
• Kai T, Akiyama Y, Nomura S, Sato M. (1996). Oral absorption improvement of poorly soluble drug using solid dispersion technique. Chem Pharm Bull, 44:568–571.
   PubMed Web of Science ®Google Scholar
• Chen R, Tagawa M, Hoshi N, Ogura T, Okamoto H, Danjo K. (2004). Improved dissolution of an insoluble drug using a 4-fluid nozzle spray-drying technique. Chem Pharm Bull, 52:1066–1070.
   PubMed Web of Science ®Google Scholar
• Cilurzo F, Minghetti P, Casiraghi A, Montanari L. (2002). Characterization of nifedipine solid dispersions. Int J Pharm, 242:313–317.
   PubMed Web of Science ®Google Scholar
• Mizoe T, Beppu S, Ozeki T, Okada H. (2007). One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier. J Control Release, 120:205–210.
   PubMed Web of Science ®Google Scholar
• Palmieri GF, Cantalamessa F, Di Martino P, Nasuti C, Martelli S. (2002). Lonidamine solid dispersions: in vitro and in vivo evaluation. Drug Dev Ind Pharm, 28:1241–1250.
   PubMed Web of Science ®Google Scholar
• Ambike AA, Mahadik KR, Paradkar A. (2005). Spray-dried amorphous solid dispersions of simvastatin, a low tg drug: in vitro and in vivo evaluations. Pharm Res, 22:990–998.
   PubMed Web of Science ®Google Scholar
• Dhumal RS, Shimpi SL, Paradkar AR. (2007). Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers. Acta Pharm, 57:287–300.
   PubMedGoogle Scholar
• Weuts I, Kempen D, Decorte A, Verreck G, Peeters J, Brewster M et al. (2004). Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64. Eur J Pharm Sci, 22:375–385.
   PubMed Web of Science ®Google Scholar
• Tewa-Tagne P, Briançon S, Fessi H. (2007). Preparation of redispersible dry nanocapsules by means of spray-drying: development and characterisation. Eur J Pharm Sci, 30:124–135.
   PubMed Web of Science ®Google Scholar
• Ozeki T, Beppu S, Mizoe T, Takashima Y, Yuasa H, Okada H. (2006). Preparation of polymeric submicron particle-containing microparticles using a 4-fluid nozzle spray drier. Pharm Res, 23:177–183.
   PubMed Web of Science ®Google Scholar
• Hu J, Johnston KP, Williams RO 3rd. (2003). Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems. Eur J Pharm Sci, 20:295–303.
   PubMed Web of Science ®Google Scholar
• Wong SM, Kellaway IW, Murdan S. (2006). Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles. Int J Pharm, 317:61–68.
   PubMed Web of Science ®Google Scholar
• Weuts I, Kempen D, Verreck G, Decorte A, Heymans K, Peeters J et al. (2005). Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying. Eur J Pharm Biopharm, 59:119–126.
   PubMed Web of Science ®Google Scholar
• Fouad EA, El-Badry M, Mahrous GM, Alanazi FK, Neau SH, Alsarra IA. (2011). The use of spray-drying to enhance celecoxib solubility. Drug Dev Ind Pharm, 37:1463–1472.
   PubMed Web of Science ®Google Scholar
• Yassin AE, Alanazi FK, El-Badry M, Alsarra IA, Barakat NS, Alanazi FK. (2009). Preparation and characterization of spironolactone-loaded gelucire microparticles using spray-drying technique. Drug Dev Ind Pharm, 35:297–304.
   PubMed Web of Science ®Google Scholar
• Serajuddin AT. (2007). Salt formation to improve drug solubility. Adv Drug Deliv Rev, 59:603–616.
   PubMed Web of Science ®Google Scholar
• Dürrigl M, Kregar ML, Hafner A, Klaric MŠ, Filipovic-Grcic J. (2011). Mupirocin calcium microencapsulation via spray drying: feed solvent influence on microparticle properties, stability and antimicrobial activity. Drug Dev Ind Pharm, 37:1402–1414.
   PubMed Web of Science ®Google Scholar